Centre staff
Dr Akram Khan
Senior lecturer in organic chemistry
Phone 0114 225 4451
Email m.a.khan@shu.ac.uk
Research interests
Novel organic compounds
Research has allowed the development of a large variety of organic compounds, with the potential therapeutic activity in a number of chronic inflammatory diseases. In addition, a number of compounds with anti-microbial activity are also under development. The synthetic programme is focussed on a number of categories of compounds.
Substituted quinolines
A wide group of substituted quinolines have been made using multi-step synthesis procedures. These compounds have shown promising pharmacological activity and are currently being investigated for a diverse range of therapeutic applications.
Nigellicine analogues
A number of synthetic routes have been investigated for generating synthetic analogues of nigellicine; an indazole alkaloid isolated from Nigella sativa Linn. These derivatives of Nigellicine are expected to show potent biological profiles because the seeds from which the alkaloids initially originate have many proven medicinal properties. This research is concentrating on the potential that these compounds may have to generate viable pharmaceutical products in the future.
Curcumoids
Novel curcuminoids of substituted aromatic and aromatic heterocyclic nature.
Anti-inflammatory drugs
A variety of derivatives based upon existing non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen and naproxen have been developed, with a view to modulating their activity and use.
