Centre staff
Dr Vikki Carolan
Senior lecturer in analytical science
Phone 0114 225 3040
Email v.a.carolan@shu.ac.uk
Research interests
Surface analysis and separations in biological systems
The uptake of agrichemicals in plants
This work is focussed on comparing the use of imaging MALDI-MS with imaging ToF-SIMS in the study of uptake by plants. It is part of a larger project conducted by Professor Malcolm Clench and funded by Syngenta, Jealots Hill.
Trans-dermal permeation of xenobiotics
A study of the permeation of various xenobiotic substances, using MS techniques. This work is conducted in collaboration with Professor Malcolm Clench and Dr J Morton of the HSL, Buxton.
Calcification of prosthetic heart values
Study of the calcification of glutaraldehyde treated bioprosthetic heart valves, using techniques such as environmental scanning electron microscopy and mass spectrometry. This work was undertaken in collaboration with colleagues in MERI and at the University of Sheffield.
Characterisation of stationary phases used in HPLC and CE
This study investigates the link between the physicochemical properties of chromatographic materials and their separating properties. X-ray photoelectron spectroscopy and SEM have been used to characterise the materials.
Collaborators
- Dr DA Barrett and Professor MC Davies, Dept Pharm Scis, University of Nottingham
- Dr J Morton, HSL
- Dr P Lawford, Dept Medical Physics, University of Sheffield
Publications
Anderson D.M.G., Carolan V.A., Crosland S, Sharples K.R. and Clench M.R. (2010) Examination of the Translocation of Sulfonylurea Herbicides in Sunflower Plants by MALDI-MSI. Rapid Communications in Mass Spectrometry 24, 3309-3319
Djidja M-C., Claude E, Snell M, Scriven P., Carolan V.A. and Clench M.R. (2010) Novel Molecular Tumour Classification using MALDI-Mass Spectrometry Imaging of Tissue MicroArray. Analytical and Bioanalytical Chemistry 397, 587-601
Djidja M-C., Claude E, Snell M, Scriven P., Francese S., Carolan V.A. and Clench M.R. (2009) MALDI-Ion Mobility Separation-Mass Spectrometry Imaging of Glucose-Regulated Protein 78 kDa (Grp78) in Human Formalin Fixed Paraffin Embedded Pancreatic Adenocarcinoma Tissue Sections. Journal of Proteome Research 8,4876-4884
Anderson DMG, Carolan VA, Crosland S, Sharples KR and Clench MR. (2009) Examination of the Distribution of Nicosulfuron in Sunflower Plants by MALDI-MSI. Rapid Communications in Mass Spectrometry 23,1321-1327
Djidja M-C., Carolan V.A., Loadman P.M. and Clench M.R. (2008) Method Development for Protein Profiling in Biological Tissues by MALDI-Mass Spectrometry Imaging. Rapid Communications in Mass Spectrometry 22,1615-1618
Delogne, C., Lawford P, Habesch, S.M. and Carolan, V.A. (2007) Characterisation of the calcification of cardiac valve bioprostheses by environmental scanning electron microscopy and vibrational spectroscopy. Journal of Microscopy, 228(1). 62-77.
Warburton K.E., Clench M.R., Ford M.J., White J., Rimmer D.A. and Carolan V.A. (2005) Characterisation of Derivatised Monomeric and Prepolymeric Isocyanates by MALDI-TOF-MS and Structural Elucidation by Tandem MS. European Mass Spectrometry 11: 565-574.
Morton, J., Carolan, V.A., Gardiner, P.H.E. (2002). The speciation of inorganic and methyl mercury in human hair by high performance liquid chromatography coupled with inductively coupled plasma mass spectrometry. Journal of Analytical Atomic Spectrometry, 17: 377-381.
Morton, J., Carolan, V.A., Gardiner, P.H.E. (2002). The removal of exogenously bound elements from human hair by various washing procedures and determination by inductively coupled plasma-mass spectrometry. Analytica Chimica Acta, 455: 23-24.
Barrett, D.A., Brown, V.A., Watson, R.C., Davies, M.C., Shaw, P.N., Ritchie, H.J., Ross, P. (2001). Effects of acid treatment on the trace metal content of chromatographic silica: bulk analysis, surface analysis and chromatographic performance of bonded phases. Journal of Chromatography A, 905: 69-83.
PhD students
- Elizabeth Leese - Methods to Investigate Occupational Exposure to Toxic Metals and their Species
