I joined Hallam in 2011 in the role of research assistant in the Materials and Engineering Research Institute and became a Researcher/Lecturer in 2015. I teach in the Department of Engineering and Mathematics in addition to delivering analytical consultancy work for industrial clients.
I graduated as a Diplom-Ingenieur (FH) in Chemistry with Marketing with a focus on Biotechnology from the University of Reutlingen in 2005. I was introduced to research in my final year, completing a project to determine the active pharmaceutical ingredient concentration of tablets employing an on-line near infrared reflectance imaging system, utilising chemometric data analysis methods.
I moved to England in 2006 to work on a multidisciplinary ESPRC funded project (Grant Nos. EP/D502748/1, EP/D50273X/1 and EP/D502721/1) studying trans-dermal drug delivery with a novel ATR-FTIR imaging set-up. I completed my PhD in ATR-FTIR spectroscopic imaging and multivariate data analysis at the University of Greenwich in 2010, and remained at the University of Greenwich in a research assistant role contributing to multidisciplinary projects aimed at the development of novel delivery systems for sensitive bio-materials.
In 2011, I joined the Polymer, Composites and Spectroscopy group in MERI working on a European 7th Framework project entitled NPmimetic (ref. 246351), with the overall aim to design and create a synthetic, polymeric implant for minimally invasive treatment of degenerated spinal discs.
Department of Engineering and Mathematics
Business, Technology and Enterprise
- Materials and Engineering Research Institute
Spectral imaging of complex biological samples can often be non-trivial due to several factors including sample preparation, overlapping peaks from the large number of proteins, sugars and other matrix components, as well as the very large data sets arising from the multitude of spectra which go into creating an image.
My research interests lie in spectroscopic imaging and the application of multivariate data analysis techniques such as principal component analysis and iterative multivariate curve resolution algorithms aimed at simplifying data sets and extracting relevant information to ultimately understand the relationship between molecular make-up and material structure and function.
I am also interested in the application of multivariate calibration and classification methods to build comprehensive predictive models, for example for disease diagnosis, material design, process optimisation and advanced process control.
Janani, R., Mader, K., Roberts, A.J., Farmilo, N., & Sammon, C. (2018). Fast-cure ionogel electrolytes with improved ion transport kinetics at room temperature. Journal of Power Sources, 406, 141-150. http://doi.org/10.1016/j.jpowsour.2018.10.049
Emanuel, K.S., Mader, K.T., Peeters, M., Kingma, I., Rustenburg, C.M.E., Vergroesen, P.-.P.A., ... Smit, T.H. (2018). Early changes in the extracellular matrix of the degenerating intervertebral disc, assessed by Fourier transform infrared imaging. Osteoarthritis and cartilage. http://doi.org/10.1016/j.joca.2018.06.003
Stacey, P., Mader, K., & Sammon, C. (2017). Feasibility of the quantification of respirablecrystalline silica by mass on aerosol samplingfilters using Raman microscopy. Journal of Raman Spectroscopy, 48 (5), 720-725. http://doi.org/10.1002/jrs.5113
Li, Z., Lang, G., Karfeld-Sulzer, L.S., Mader, K., Richards, R.G., Weber, F.E., ... Grad, S. (2017). Heterodimeric BMP-2/7 for nucleus pulposus regeneration-In vitro and ex vivo studies. Journal of Orthopaedic Research, 35 (1), 51-60. http://doi.org/10.1002/jor.23351
Goodacre, R., Sergo, V., Barr, H., Sammon, C., Schultz, Z.D., Baker, M.J., ... Paterson, C. (2016). Clinical spectroscopy: general discussion. Faraday Discuss, 187, 429-460. http://doi.org/10.1039/C6FD90013E
Mader, K., Peeters, M., Detiger, S.E.L., Helder, M.N., Smit, T.H., Le Maitre, C., & Sammon, C. (2016). Investigation of intervertebral disc degeneration using multivariate FTIR spectroscopic imaging. Faraday Discussions, 187, 393-414. http://doi.org/10.1039/c5fd00160a
Li, Z., Lang, G., Chen, X., Sacks, H., Mantzur, C., Tropp, U., ... Grad, S. (2016). Polyurethane scaffold with in situ swelling capacity for nucleus pulposus replacement. Biomaterials, 84, 196-209. http://doi.org/10.1016/j.biomaterials.2016.01.040
Mader, K.T., Le Maitre, C.L., & Sammon, C. (2014). Characterisation of intervertebral discs using MID-IR spectroscopic imaging. Global Spine Journal, 4, 58. http://doi.org/10.1055/s-0034-1376632
Bradshaw, R., Wolstenholme, R., Ferguson, L.S., Sammon, C., Mader, K., Claude, E., ... Francese, S. (2013). Spectroscopic imaging based approach for condom identification in condom contaminated fingermarks. The Analyst, 138 (9), 2546. http://doi.org/10.1039/c3an00195d
McAuley, W.J., Chavda-Sitaram, S., Mader, K.T., Tetteh, J., Lane, M.E., & Hadgraft, J. (2013). The effects of esterified solvents on the diffusion of a model compound across human skin: An ATR-FTIR spectroscopic study. International Journal of Pharmaceutics, 447 (1-2), 1-6. http://doi.org/10.1016/j.ijpharm.2013.02.022
McAuley, W.J., Lad, M.D., Mader, K.T., Santos, P., Tetteh, J., Kazarian, S.G., ... Lane, M.E. (2010). ATR-FTIR spectroscopy and spectroscopic imaging of solvent and permeant diffusion across model membranes. European Journal of Pharmaceutics and Biopharmaceutics, 74 (2), 413-419. http://doi.org/10.1016/j.ejpb.2009.11.004
McAuley, W.J., Mader, K.T., Tetteh, J., Lane, M.E., & Hadgraft, J. (2009). Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy. European Journal of Pharmaceutical Sciences, 38 (4), 378-383. http://doi.org/10.1016/j.ejps.2009.09.002
Tetteh, J., Mader, K.T., Andanson, J.M., McAuley, W.J., Lane, M.E., Hadgraft, J., ... Mitchell, J.C. (2009). Local examination of skin diffusion using FTIR spectroscopic imaging and multivariate target factor analysis. Analytica Chimica Acta, 642 (1-2), 246-256. http://doi.org/10.1016/j.aca.2009.03.002