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Professor Malcolm Clench

Professor of Mass Spectrometry, Head of the Biomolecular Sciences Research Centre


Summary

Professor of Mass Spectrometry, Head of the Biomolecular Sciences Research Centre

About

I was appointed to Sheffield Hallam University in 1990 having spent a time in the scientific instrument industry working for VG (now Waters) and Kratos Analytical (now Shimadzu).

I completed my undergraduate degree in Applied Chemistry at Sheffield City Polytechnic in 1981 and my PhD in "Strategies for Protein and Peptide Analysis by Fast Atom Bombardment Mass Spectrometry" as a collaborative project between Manchester Polytechnic and The University of Manchester Institute of Science and Technology in 1988.

I have published 117 papers, one book and three book chapters. I have been Director of Studies for 35 PhD completions including a number of split and part-time PhDs.

I lead the Imaging and MALDI Special Interest Group of the British Mass Spectrometry Society and was awarded the Society's Lectureship 2006-2008. I am a member of the Executive Advisory Board of the Journal "Proteomics" and was UK Management Representative for EU COST Action BM1104 Mass Spectrometry Imaging: New Tools for Healthcare Research 2012-2015.

Teaching

 I teach Advanced Topics in Mass Spectrometry, Toxicology, Proteomics and Metabolomics. 

Research

My research interests cover the development and application of techniques in mass spectrometry imaging. In recent years I have become interested in how the combination of mass spectrometry imaging with 3D cell culture can be developed to provide a powerful platform for early stage safety and efficacy testing of drugs and toxicants.

Biomedical and environmental mass spectrometry

Mass spectrometry (MS) is used to solve a range of bioanalytical problems. In particular a range of projects are in progress which are concerned with the utilisation of matrix assisted laser desorption mass spectrometry imaging (MALDI-MSI) for imaging the distribution of xenobiotics and endogenous compounds in biological tissue.

Development of new techniques in mass spectrometry

For example imaging MALDI-MS. This development work is carried out in collaboration with Waters Corporation, Manchester UK and Elforlight Lid, Daventry UK and has led to one patent on improvements in MALDI sensitivity.

Development of mass spectrometric methods for the detection of xenobiotics and endogenous compounds in biological tissue

Imaging MS can be used to study the distribution of non-radiolabelled compounds within biological tissue. This offers significant advantages over conventional methods of analysis and can be used to study for example the distribution of anti-cancer drugs in tumours and to monitor the development of bacterial infections. This work is carried out in collaboration with Dr Vikki Carolan and Prof Simona Francese (BMRC), Professor Mike Burrell (University of Sheffield), Dr Peter Marshall, Josie Morrell (GlaxoSmithKline), Dr Don Richards (Pfizer Global R and D), Dr Paul Loadman (Institute of Cancer Therapeutics, University of Bradford) and Dr Andrew McEwen (Quotient Bioresearch).

Application of MALDI-MSI to pharmaco/toxicodynamic responses

Currently projects are investigating changes in protein and lipid expression when skin is exposed to sensitizing chemicals and the response of tumours to treatment with vascular disrupting agents (VDA) by this approach.


Current work is supported by grants and gifts of equipment from MRC/GSK, CRUK/EPSRC, The British Mass Spectrometry Society, Syngenta and Pfizer Global R&D.

Publications

Journal articles

Cole, L.M., Handley, J., Claude, E., Duckett, C.J., Mudhar, H.S., Sisley, K., & Clench, M.R. (2021). Multi-Modal Mass Spectrometric Imaging of Uveal Melanoma. Metabolites, 11 (8). http://doi.org/10.3390/metabo11080560

Flint, L.E., Hamm, G., Ready, J.D., Ling, S., Duckett, C.J., Cross, N.A., ... Clench, M.R. (2021). Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging. Metabolites, 11 (8). http://doi.org/10.3390/metabo11080506

Angelini, R., Yutuc, E., Wyatt, M.F., Newton, J., Yusuf, F.A., Griffiths, L., ... Griffiths, W.J. (2021). Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging. Analytical Chemistry. http://doi.org/10.1021/acs.analchem.0c05399

Spencer, C.E., Flint, L.E., Duckett, C., Cole, L., Cross, N., Smith, D., & Clench, M. (2021). Role of MALDI-MSI in combination with 3D tissue models for early stage efficacy and safety testing of drugs and toxicants. Expert Review of Proteomics, 17 (11-12), 827-841. http://doi.org/10.1080/14789450.2021.1876568

Pérez-López, A.V., Simpson, J., Clench, M., Gomez-Vargas, A.D., & Ordaz-Ortiz, J.J. (2021). Localization and Composition of Fructans in Stem and Rhizome of Agave tequilana Weber var. azul. Frontiers in Plant Science, 11, 608850. http://doi.org/10.3389/fpls.2020.608850

Couto, N., Newton, J.R.A., Russo, C., Karunakaran, E., Achour, B., Al-Majdoub, Z.M., ... Barber, J. (2021). Label-free Quantitative Proteomics and Substrate Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in ex Vivo Human Skin and a Human Living Skin Equivalent Model. Drug Metabolism and Disposition. http://doi.org/10.1124/dmd.120.000168

Handler, A.M., Pommergaard Pedersen, G., Troensegaard Nielsen, K., Janfelt, C., Just Pedersen, A., & Clench, M. (2020). Quantitative MALDI mass spectrometry imaging for exploring cutaneous drug delivery of tofacitinib in human skin. European Journal of Pharmaceutics and Biopharmaceutics, 159, 1-10. http://doi.org/10.1016/j.ejpb.2020.12.008

Flinders, B., Morrell, J., Marshall, P.S., Ranshaw, L.E., Heeren, R.M.A., & Clench, M. (2020). Monitoring the three-dimensional distribution of endogenous species in the lungs by matrix-assisted laser desorption/ionization mass spectrometry imaging. Rapid Communications in Mass Spectrometry, 35 (1), e8957. http://doi.org/10.1002/rcm.8957

Russo, C., Heaton, C., Flint, L., Voloaca, O., Haywood-Small, S., Clench, M., ... Cole, L. (2020). Emerging applications in mass spectrometry imaging; enablers and roadblocks. Journal of Spectral Imaging, 9, 1-21. http://doi.org/10.1255/jsi.2020.a13

Kennedy, K., Heaton, C., Langenburg, G., Cole, L., Clark, T., Clench, M.R., ... Francese, S. (2020). Pre-validation of a MALDI MS proteomics-based method for the reliable detection of blood and blood provenance. Scientific Reports, 10 (1), 17087. http://doi.org/10.1038/s41598-020-74253-z

Heaton, C., Bury, C., Patel, E., Bradshaw, R., Wulfert, F., Heeren, R., ... Francese, S. (2020). Investigating sex determination through MALDI MS analysis of peptides and proteins in natural fingermarks through comprehensive statistical modelling. Forensic Chemistry, 20 (100271), 1-12. http://doi.org/10.1016/j.forc.2020.100271

Voloaca, O.M., Greenhalgh, C.J., Cole, L., Clench, M.R., Managh, A.J., & Haywood-Small, S. (2020). Laser ablation inductively coupled plasma mass spectrometry as a novel clinical imaging tool to detect asbestos fibres in malignant mesothelioma. Rapid Communications in Mass Spectrometry, 34 (21), e8906. http://doi.org/10.1002/rcm.8906

Flint, L.E., Hamm, G., Ready, J.D., Ling, S., Duckett, C.J., Cross, N.A., ... Clench, M.R. (2020). Characterization of an Aggregated Three-Dimensional Cell Culture Model by Multimodal Mass Spectrometry Imaging. Analytical Chemistry. http://doi.org/10.1021/acs.analchem.0c02389

Greenhalgh, C.J., Voloaca, O.M., Shaw, P., Donard, A., Cole, L.M., Clench, M.R., ... Haywood-Small, S.L. (2020). Needles in haystacks: using fast-response LA chambers and ICP-TOF-MS to identify asbestos fibres in malignant mesothelioma models. Journal of Analytical Atomic Spectrometry. http://doi.org/10.1039/d0ja00268b

Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., ... Griffiths, W.J. (2020). Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism. Proceedings of the National Academy of Sciences, 201917421. http://doi.org/10.1073/pnas.1917421117

Palubeckaitė, I., Crooks, L., Smith, D., Cole, L., Bram, H., Le Maitre, C., ... Cross, N.A. (2019). Mass spectrometry imaging of endogenous metabolites in response to doxorubicin in a novel 3D osteosarcoma cell culture model. Journal of Mass Spectrometry. http://doi.org/10.1002/jms.4461

Jove, M., Spencer, J., Clench, M., Loadman, P.M., & Twelves, C. (2019). Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance. Critical Reviews in Oncology/Hematology, 141, 153-162. http://doi.org/10.1016/j.critrevonc.2019.06.008

Cole, L., Clench, M., & Francese, S. (2019). Sample treatment for tissue proteomics in cancer, toxicology, and forensics. Adv Exp Med Biol, 1073 (1073), 77-123. http://doi.org/10.1007/978-3-030-12298-0_4

Harding, A.J., Hough, J., Curtis, C., Kinsman, D., & Clench, M. (2019). Matrix-assisted ionisation in vacuum mass spectrometry and imaging on a modified quadrupole-quadrupole-time-of-flight mass spectrometer. Journal of Spectral Imaging, 8, a12. http://doi.org/10.1255/jsi.2019.a12

Francese, S. (2018). Investigation of infinite focus microscopy for the determination of the association of blood with fingermarks. Science & Justice, 58 (6), 397-404. http://doi.org/10.1016/j.scijus.2018.07.001

Russo, C., Brickelbank, N., Duckett, C., Mellor, S., Rumbelow, S., & Clench, M. (2018). Quantitative investigation of terbinafine hydrochloride absorption into a living skin equivalent model by MALDI-MSI. Analytical chemistry, 90 (16), 10031-10038. http://doi.org/10.1021/acs.analchem.8b02648

Russo, C., Lewis, E., Flint, L., & Clench, M. (2018). Mass spectrometry imaging of 3D tissue models. Proteomics, 18 (14). http://doi.org/10.1002/pmic.201700462

Swales, J., Dexter, A., Hamm, G., Nilsson, A., Strittmatter, N., Michopoulos, F., ... Goodwin, R.J.A. (2018). Quantitation of endogenous metabolites in mouse tumors using mass-spectrometry imaging. Analytical Chemistry, 90 (10), 6051-6058. http://doi.org/10.1021/acs.analchem.7b05239

Lewis, E.E.L., Barrett, M.R.T., Freeman-Parry, L., Bojar, R.A., & Clench, M. (2018). Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption-ionization-mass spectrometry imaging (MALDI-MSI). International journal of cosmetic science, 40 (2), 148-156. http://doi.org/10.1111/ics.12446

Swales, J.G., Hamm, G., Clench, M., & Goodwin, R.J.A. (2018). Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review. International Journal of Mass Spectrometry. http://doi.org/10.1016/j.ijms.2018.02.007

Slowinska, M., Sallem, H., Clench, M., & Ciereszko, A. (2018). Metabolomic analysis of white and yellow seminal plasma in turkeys (Meleagris gallopavo)1. Poultry science, 97 (3), 1059-1065. http://doi.org/10.3382/ps/pex366

Wojakowska, A., Cole, L., Chekan, M., Bednarczyk, K., Maksymiak, M., Oczko-Wojciechowska, M., ... Widlak, P. (2018). Discrimination of papillary thyroid cancer from non-cancerous thyroid tissue based on lipid profiling by mass spectrometry imaging. Endokrynologia Polska, 69 (1), 2-8. http://doi.org/10.5603/EP.a2018.0003

Flinders, B., Beasley, E., Verlaan, R.M., Cuypers, E., Francese, S., Bassindale, T., ... Heeren, R.M.A. (2017). Optimization of sample preparation and instrumental parameters for the rapid analysis of drugs of abuse in hair samples by MALDI-MS/MS imaging. Journal of the American Society for Mass Spectrometry, 28 (11), 2462-2468. http://doi.org/10.1007/s13361-017-1766-0

Leese, E., Clench, M., Morton, J., Gardiner, P., & Carolan, V. (2017). The investigation of unexpected arsenic compounds observed in routine biological monitoring urinary speciation analysis. Toxics, 5 (2), 12. http://doi.org/10.3390/toxics5020012

Hart, P.J., & Clench, M.R. (2017). MALDI-MSI of lipids in human skin. . http://doi.org/10.1007/978-1-4939-7051-3_4

Djidja, M.-.C., Claude, E., Scriven, P., Allen, D., Carolan, V., & Clench, M. (2016). Antigen retrieval prior to on-tissue digestion of formalin-fixed paraffin-embedded tumour tissue sections yields oxidation of proline residues. Biochimica et biophysica acta, 1865 (7), 901-906. http://doi.org/10.1016/j.bbapap.2016.11.019

Swales, J.G., Strittmatter, N., Tucker, J.W., Clench, M., Webborn, P.J.H., & Goodwin, R.J.A. (2016). Spatial quantitation of drugs in tissues using liquid extraction surface analysis mass spectrometry imaging. Scientific Reports, 6, 37648. http://doi.org/10.1038/srep37648

Mitchell, C.A., Donaldson, M., Francese, S., & Clench, M. (2016). MALDI MSI analysis of lipid changes in living skin equivalents in response to emollient creams containing palmitoylethanolamide. Methods, 104, 93-100. http://doi.org/10.1016/j.ymeth.2016.02.001

Walker, H.J., Steels, C., Bendell, L., Clench, M.R., Read, D.J., Cameron, D.D., & Burrell, M.M. (2016). Understanding metabolism of arginine in biological systems via MALDI imaging. Proteomics, 16 (11-12), 1690-1694. http://doi.org/10.1002/pmic.201500493

Deininger, L., Patel, E., Clench, M.R., Sears, V., Sammon, C., & Francese, S. (2016). Proteomics goes forensic: detection and mapping of blood signatures in fingermarks. Proteomics, 16 (11-12), 1707-1717. http://doi.org/10.1002/pmic.201500544

Harvey, A., Day, R., Cole, L.M., Bartlett, M., Warwick, J., Bojar, R., ... Clench, M.R. (2016). MALDI-MSI for the analysis of a 3D tissue-engineered psoriatic skin model. Proteomics, 16 (11-12), 1718-1725. http://doi.org/10.1002/pmic.201600036

Clench, M.R. (2016). Advances in mass spectrometry imaging. Proteomics, 16 (11-12), 1605-1606. http://doi.org/10.1002/pmic.201600202

Deininger, L., Patel, E., Clench, M.R., Sears, V., Sammon, C., & Francese, S. (2016). Outside Front Cover: Proteomics goes forensic: Detection and mapping of blood signatures in fingermarks. Proteomics, 16 (11-12), 1. http://doi.org/10.1002/pmic.201670110

Martin, S., Lenz, E.M., Smith, R., Temesi, D.G., Orton, A.L., & Clench, M. (2016). Methanol adducts leading to the identification of a reactive aldehyde metabolite of CPAQOP in human liver microsomes by ultra-high-performance liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry, 31 (1), 145-151. http://doi.org/10.1002/rcm.7772

Patel, E., Cicatiello, P., Deininger, L., Clench, M., Marino, G., Giardina, P., ... Francese, S. (2016). A proteomic approach for the rapid, multi-informative and reliable identification of blood. The Analyst, 141 (1), 191-198. http://doi.org/10.1039/c5an02016f

Patel, E., Cole, L.M., Bradshaw, R., Batubara, A., Mitchell, C.A., Francese, S., & Clench, M. (2015). MALDI-MS imaging for the study of tissue pharmacodynamics and toxicodynamics. Bioanalysis, 7 (1), 91-101. http://doi.org/10.4155/bio.14.280

Cole, L.M., Selvan, A.N., Partridge, R., Reed, H., Wright, C., & Clench, M.R. (2015). Communication of medical images to diverse audiences using multimodal imaging. Advanced Structural and Chemical Imaging, 1 (1). http://doi.org/10.1186/s40679-015-0012-8

Curtis, A., Morton, J., Fraser, S., Harding, A.-.H., Prideaux, B., Clench, M., ... Evans, G.S. (2015). Can the KG1 cell line be used as a model of dendritic cells and discriminate the sensitising potential of chemicals? Toxicology Letters, 239 (1), 32-40. http://doi.org/10.1016/j.toxlet.2015.08.006

Patel, E., Clench, M.R., West, A., Marshall, P.S., Marshall, N., & Francese, S. (2015). Erratum: Alternative surfactants for improved efficiency of in situ tryptic proteolysis of fingermarks (Journal of the American Society for Mass Spectrometry (2015) 26 (862-872) DOI: 10.1007/s13361-015-1140-z). Journal of the American Society for Mass Spectrometry, 26 (10), 1795. http://doi.org/10.1007/s13361-015-1216-9

Swales, J.G., Tucker, J.W., Spreadborough, M.J., Iverson, S.L., Clench, M., Webborn, P.J.H., & Goodwin, R.J.A. (2015). Mapping drug distribution in brain tissue using liquid extraction surface analysis mass spectrometry imaging. Analytical Chemistry, 87 (19), 10146-10152. http://doi.org/10.1021/acs.analchem.5b02998

Mitchell, C.A., Long, H., Donaldson, M., Francese, S., & Clench, M. (2015). Lipid changes within the epidermis of living skin equivalents observed across a time-course by MALDI-MS imaging and profiling. Lipids in Health and Disease, 14 (1), 84. http://doi.org/10.1186/s12944-015-0089-z

Batubara, A., Carolan, V.A., Loadman, P.M., Sutton, C., Shnyder, S.D., & Clench, M.R. (2015). Thin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treated with the vascular disrupting agent DMXAA. Rapid Communications in Mass Spectrometry, 29 (14), 1288-1296. http://doi.org/10.1002/rcm.7223

Patel, E., Clench, M., West, A., Marshall, P.S., Marshall, N., & Francese, S. (2015). Alternative Surfactants for Improved Efficiency of In Situ Tryptic Proteolysis of Fingermarks. Journal of The American Society for Mass Spectrometry, 26 (6), 862-872. http://doi.org/10.1007/s13361-015-1140-z

Cole, L., & Clench, M. (2015). Mass spectrometry imaging for the proteomic study of clinical tissue. PROTEOMICS - Clinical Applications, 9 (3-4), 335-341. http://doi.org/10.1002/prca.201400103

Flinders, B., Morrell, J., Marshall, P.S., Ranshaw, L.E., & Clench, M. (2015). The use of hydrazine-based derivatization reagents for improved sensitivity and detection of carbonyl containing compounds using MALDI-MSI. Analytical and Bioanalytical Chemistry, 407 (8), 2085-2094. http://doi.org/10.1007/s00216-014-8223-8

Cole, L.M., & Clench, M.R. (2015). Mass spectrometry imaging tools in oncology. Biomarkers in Medicine, 9 (9), 863-868. http://doi.org/10.2217/bmm.15.61

Martin, S., Lenz, E.A., Keene, W., & Clench, M.R. (2014). Identification of the reactive metabolites of fenclozic acid in bile duct cannulated (BDC) rats. Analytical Chemistry, 86 (22), 11281-11289. http://doi.org/10.1021/ac502943d

Swales, J.G., Tucker, J.W., Strittmatter, N., Nilsson, A., Cobice, D., Clench, M., ... Goodwin, R.J.A. (2014). Mass spectrometry imaging of cassette-dosed drugs for higher throughput pharmacokinetic and biodistribution analysis. Analytical chemistry, 86 (16), 8473-8480. http://doi.org/10.1021/ac502217r

Seaman, C., Flinders, B., Eijkel, G., Heeren, R.M.A., Bricklebank, N., & Clench, M.R. (2014). “Afterlife Experiment”: use of MALDI-MS and SIMS imaging for the Study of the nitrogen cycle within plants. Analytical Chemistry, 86 (20), 10071-10077. http://doi.org/10.1021/ac501191w

Cole, L., Bluff, J.E., Carolan, V., Paley, M.N., Tozer, G.M., & Clench, M. (2014). MALDI-MSI and label-free LC-ESI-MS/MS shotgun proteomics to investigate protein induction in a murine fibrosarcoma model following treatment with a vascular disrupting agent. Proteomics, 14 (7-8), 890-903. http://doi.org/10.1002/pmic.201300429

Jelonek, K., Pietrowska, M., Ros, M., Zagdanski, A., Suchwalko, A., Polanska, J., ... Widlak, P. (2014). Radiation-induced changes in serum lipidome of head and neck cancer patients. International Journal of Molecular Sciences, 15 (4), 6609-6624. http://doi.org/10.3390/ijms15046609

Bradshaw, R., Bleay, S., Clench, M., & Francese, S. (2014). Direct detection of blood in fingermarks by MALDI MS profiling and imaging. Science & justice, 54 (2), 110-7. http://doi.org/10.1016/j.scijus.2013.12.004

Bradshaw, R., Bleay, S., Wolstenholme, R., Clench, M., & Francese, S. (2013). Towards the integration of matrix assisted laser desorption ionisation mass spectrometry imaging into the current fingermark examination workflow. Forensic Science International, 232 (1-3), 111-124. http://doi.org/10.1016/j.forsciint.2013.07.013

Francese, S., Bradshaw, R., Ferguson, L.S., Wolstenholme, R., Clench, M.R., & Bleay, S. (2013). Beyond the ridge pattern: multi-informative analysis of latent fingermarks by MALDI mass spectrometry. The Analyst, 138 (15), 4215. http://doi.org/10.1039/c3an36896c

Bradshaw, R., Wolstenholme, R., Ferguson, L.S., Sammon, C., Mader, K., Claude, E., ... Francese, S. (2013). Spectroscopic imaging based approach for condom identification in condom contaminated fingermarks. The Analyst, 138 (9), 2546. http://doi.org/10.1039/c3an00195d

Dahlawi, H., Jordan-Mahy, N., Clench, M., McDougall, G.J., & Le Maitre, C. (2013). Polyphenols are responsible for the proapoptotic properties of pomegranate juice on leukemia cell lines. Food Science and Nutrition, 1 (2), 196-208. http://doi.org/10.1002/fsn3.26

Hart, P.J., Francese, S., Woodroofe, M.N., & Clench, M.R. (2013). Matrix assisted laser desorption ionisation ion mobility separation mass spectrometry imaging of ex-vivo human skin. International Journal for Ion Mobility Spectrometry, 16 (2), 71-83. http://doi.org/10.1007/s12127-013-0124-6

Cole, L.M., Mahmoud, K., Haywood-Small, S., Tozer, G.M., Smith, D.P., & Clench, M.R. (2013). Recombinant "IMS TAG" proteins - A new method for validating bottom-up matrix-assisted laser desorption/ionisation ion mobility separation mass spectrometry imaging. Rapid Communications in Mass Spectrometry, 27 (21), 2355-2362. http://doi.org/10.1002/rcm.6693

Battle, R., Woodroofe, N., Clench, M., & Clark, B. (2013). The relationship of HLA-class I derived leader peptide mismatch and renal function within the first 12months post-renal transplant. Tissue Antigens, 82 (4), 291-292. http://doi.org/10.1111/tan.12191

Ferguson, L.S., Creasey, S., Wolstenholme, R., Clench, M.R., & Francese, S. (2013). Efficiency of the dry-wet method for the MALDI-MSI analysis of latent fingermarks. Journal of Mass Spectrometry, 48 (6), 677-684. http://doi.org/10.1002/jms.3216

Francese, S., Bradshaw, R., Flinders, B., Mitchell, C., Bleay, S., Cicero, L., & Clench, M.R. (2013). Curcumin: A multipurpose matrix for MALDI mass spectrometry imaging applications. Analytical Chemistry, 85 (10), 5240-5248. http://doi.org/10.1021/ac4007396

Djidja, M.-.C., Francese, S., Claude, E., Loadman, P., Sutton, C., Shynder, S., ... Clench, M. (2013). Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging. Current Analytical Chemistry, 9 (2), 212-225. http://doi.org/10.2174/157341113805218884

Mahmoud, K., Cole, L., Newton, J., Mohamed, S., Al-Enazi, M., Qirke, P., & Clench, M. (2013). Detection of the epidermal growth factor receptor, amphiregulin and epiregulin in formalin-fixed paraffin-embedded human placenta tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging. European Journal of Mass Spectrometry, 19 (1), 17-28. http://doi.org/10.1255/ejms.1212

Ramirez, T., Daneshian, M., Kamp, H., Bois, F.Y., Clench, M.R., Coen, M., ... Leist, M. (2013). T4 Report* Metabolomics in toxicology and preclinical research. Altex, 30 (2), 209-225. http://doi.org/10.14573/altex.2013.2.209

Ferguson, L.S., Wulfert, F., Wolstenholme, R., Fonville, J.M., Clench, M., Carolan, V.A., & Francese, S. (2012). Direct detection of peptides and small proteins in fingermarks and determination of sex by MALDI mass spectrometry profiling. The Analyst, 137 (20), 4686-4692. http://doi.org/10.1039/c2an36074h

Bradshaw, R., Rao, W., Wolstenholme, R., Clench, M.R., Bleay, S., & Francese, S. (2012). Separation of overlapping fingermarks by Matrix Assisted Laser Desorption Ionisation Mass Spectrometry Imaging. Forensic Science International, 222 (1), 318-326. http://doi.org/10.1016/j.forsciint.2012.07.009

Dahlawi, H., Jordan-Mahy, N., Clench, M., & Le Maitre, C. (2012). Bioactive actions of pomegranate fruit extracts on leukemia cell lines In vitro hold promise for new therapeutic agents for leukemia. Nutrition and Cancer, 64 (1), 100-110. http://doi.org/10.1080/01635581.2012.630155

Seppala, U., Francese, S., Turillazi, S., Moneti, G., Clench, M., & Barber, D. (2012). In situ imaging of honeybee (Apis mellifera) venom components from aqueous and aluminum hydroxide-adsorbed venom immunotherapy preparations. Journal of Allergy and Clinical Immunology, 129 (5), 1314-1320. http://doi.org/10.1016/j.jaci.2011.10.014

Martin, S., Lenz, E.M., Temesi, D., Wild, M., & Clench, M. (2012). Reaction of homopiperazine with endogenous formaldehyde. A carbon hydrogen addition metabolite/product identified in rat urine and blood. Drug Metabolism and Disposition, 40 (8), 1478-1486. http://doi.org/10.1124/dmd.112.044917

Trim, P.J., Djidja, M.-.C., Muharib, T., Cole, L.M., Flinders, B., Carolan, V., ... Clench, M. (2012). Instrumentation and software for mass spectrometry imaging -making the most of what you've got. Journal of Proteomics, 75 (16), 4931-4940.

Zaini, R.G., Brandt, K., Clench, M., & Le Maitre, C. (2012). Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells. Anti-Cancer Agents in Medicinal Chemistry, 12 (6), 640-652.

Ferguson, L., Bradshaw, R., Wolstenholme, R., Clench, M., & Francese, S. (2011). Two-step matrix application for the enhancement and imaging of latent fingermarks. Analytical Chemistry, 83 (14), 5585-5591. http://doi.org/10.1021/ac200619f

Cole, L., Djidja, M.-.C., Bluff, J., Claude, E., Carolan, V., Paley, M., ... Clench, M. (2011). Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI. Methods, 54 (4), 442-453. http://doi.org/10.1016/j.ymeth.2011.03.007

Avery, J.L., McKewen, A., Flinders, B., Francese, S., & Clench, M. (2011). Matrix assisted laser desorption mass spectrometry imaging for the examination of imipramine absorption by straticell-RHE-EPI/001 an artificial model of the human epidermis. Xenobiotica, 41 (8), pp 735-742. http://doi.org/10.3109/00498254.2011.573015

Bradshaw, R., Wolstenholme, R., Blackledge, R.D., Clench, M.R., Ferguson, L.S., & Francese, S. (2011). A novel matrix-assisted laser desorption/ionisation mass spectrometry imaging based methodology for the identification of sexual assault suspects. Rapid Communications in Mass Spectrometry, 25 (3), 415-422. http://doi.org/10.1002/rcm.4858

Zaini, R., Clench, M., & Le Maitre, C. (2011). Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia. Journal of Medicinal Food, 14 (11), 1-10. http://doi.org/10.1089/jmf.2010.0284

Hart, P.J., Francese, S., Claude, E., Woodroofe, M.N., & Clench, M.R. (2011). MALDI-MS imaging of lipids in ex vivo human skin. Analytical and Bioanalytical Chemistry, 401 (1), 115-125. http://doi.org/10.1007/s00216-011-5090-4

Anderson, D.M.G., Carolan, V.A., Crosland, S., Sharples, K.R., & Clench, M.R. (2010). Examination of the translocation of sulfonylurea herbicides in sunflower plants by matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid Communications in Mass Spectrometry, 24 (22), 3309-3319. http://doi.org/10.1002/rcm.4767

Trim, P.J., Djidja, M.C., Atkinson, S.J., Oakes, K., Cole, L.M., Anderson, D.M.G., ... Clench, M.R. (2010). Introduction of a 20 kHz Nd:YVO4 laser into a hybrid quadrupole time-of-flight mass spectrometer for MALDI-MS imaging. Analytical and Bioanalytical Chemistry, 397 (8), 3409-3419. http://doi.org/10.1007/s00216-010-3874-6

Earnshaw, C.J., Carolan, V.A., Richards, D.S., & Clench, M.R. (2010). Direct analysis of pharmaceutical tablet formulations using matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid Communications in Mass Spectrometry, 24 (11), 1665-1672. http://doi.org/10.1002/rcm.4525

Djidja, M.C., Claude, E., Snel, M.F., Francese, S., Scriven, P., Carolan, V., & Clench, M.R. (2010). Novel molecular tumour classification using MALDI-mass spectrometry imaging of tissue micro-array. Analytical and Bioanalytical Chemistry, 397 (2), 587-601. http://doi.org/10.1007/s00216-010-3554-6

Djidja, M.-.C., Claude, E., Snel, M.F., Scriven, P., Francese, S., Carolan, V., & Clench, M.R. (2009). MALDI-Ion Mobility Separation-Mass Spectrometry Imaging of Glucose-Regulated Protein 78 kDa (Grp78) in Human Formalin-Fixed, Paraffin-Embedded Pancreatic Adenocarcinoma Tissue Sections. Journal of Proteome Research, 8 (10), 4876-4884. http://doi.org/10.1021/pr900522m

Wolstenholme, R., Bradshaw, R., Clench, M.R., & Francese, S. (2009). Study of latent fingermarks by matrix-assisted laser desorption/ionisation mass spectrometry imaging of endogenous lipids. Rapid communications in mass spectrometry, 23 (19), 3031-3039. http://doi.org/10.1002/rcm.4218

Anderson, D.M.G., Carolan, V.A., Crosland, S., Sharples, K.R., & Clench, M.R. (2009). Examination of the distribution of nicosulfuron in sunflower plants by matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid communications in mass spectrometry, 23 (9), 1321-1327. http://doi.org/10.1002/rcm.3973

Djidja, M.C., Francese, S., Loadman, P.M., Sutton, C.W., Scriven, P., Claude, E., ... Clench, M.R. (2009). Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification forin situproteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections. Proteomics, 9 (10), 2750-2763. http://doi.org/10.1002/pmic.200800624

Zhou, Y., Taylor, B., Smith, T.J., Liu, Z.-.P., Clench, M., Davies, N.W., & Rainsford, K.D. (2009). A novel compound from celery seed with a bactericidal effect against Helicobacter pylori. Journal of pharmacy and pharmacology, 61 (8), 1067-1077. http://doi.org/10.1211/jpp/61.08.0011

Trim, P.J., Francese, S., & Clench, M.R. (2009). Imaging mass spectrometry for the assessment of drugs and metabolites in tissue. Bioanalysis, 1 (2), 309-319. http://doi.org/10.4155/BIO.09.33

Denney, H., Clench, M., & Woodroofe, M.N. (2009). Cleavage of chemokines CCL2 and CXCL10 by matrix metalloproteinases-2 and -9: implications for chemotaxis. Biochemical and biophysical research communications, 382 (2), 341-347. http://doi.org/10.1016/j.bbrc.2009.02.164

Trim, P.J., Atkinson, S.J., Princivalle, A.P., Marshall, P.S., West, A., & Clench, M.R. (2008). Matrix-assisted laser desorption/ionisation mass spectrometry imaging of lipids in rat brain tissue with integrated unsupervised and supervised multivariant statistical analysis. Rapid Communications in Mass Spectrometry, 22 (10), 1503-1509. http://doi.org/10.1002/rcm.3498

Djidja, M.C., Carolan, V., Loadman, P.M., & Clench, M.R. (2008). Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid communications in mass spectrometry, 22 (10), 1615-1618. http://doi.org/10.1002/rcm.3503

Trim, P.J., Henson, C.M., Avery, J.L., McEwen, A., Snel, M.F., Claude, E., ... Clench, M.R. (2008). Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections. Analytical chemistry, 80 (22), 8628-8634. http://doi.org/10.1021/ac8015467

Newton, K.A., Clench, M.R., Deshmukh, R., Jeyaseelan, K., & Strong, P.N. (2007). Mass fingerprinting of toxic fractions from the venom of the Indian red scorpion, Mesobuthus tamulus: Biotope-specific variation in the expression of venom peptides. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21 (21), 3467-3476. http://doi.org/10.1002/rcm.3240

Mreyen, M., Barnes, A., Earnshaw, C.J., Atkinson, S.J., Burrell, M., & Clench, M.R. (2007). MALDI imaging mass spectrometry: Better data quality by automatic sample preparation. BioSpektrum, 13 (5), 514-515.

Newton, K.A., Clench, M.R., Deshmukh, R., Jeyaseelan, K., & Strong, P.N. (2007). Mass fingerprinting of toxic fractions from the venom of the Indian red scorpion, mesobuthus tamulus: biotope-specific variation in the expression of venom peptides. Rapid communications in mass spectrometry, 21 (21), 3467-3476. http://doi.org/10.1002/rcm.3240

Burrell, M.M., Earnshaw, C.J., & Clench, M.R. (2007). Imaging Matrix Assisted Laser Desorption Ionization Mass Spectrometry: A technique to map plant metabolites within tissues at high spatial resolution. Journal of Experimental Botany, 58 (4), 757-763. http://doi.org/10.1093/jxb/erl139

Atkinson, S.J., Loadman, P.M., Sutton, C., Patterson, L.H., & Clench, M.R. (2007). Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry. Rapid communications in mass spectrometry, 21 (7), 1271-1276. http://doi.org/10.1002/rcm.2952

Robinson, S., Warburton, K., Seymour, M., Clench, M., & Thomas-Oates, J. (2007). Localization of water-soluble carbohydrates in wheat stems using imaging matrix-assisted laser desorption ionization mass spectrometry. New Phytologist, 173 (2), 438-444. http://doi.org/10.1111/j.1469-8137.2006.01934.x

Earnshaw, C.J., Atkinson, S.J., Burrell, M., & Clench, M.R. (2007). Matrix assisted laser desorption ionisation mass spectrometric imaging - Principles and applications. RSC Biomolecular Sciences, 234-253. http://doi.org/10.1039/9781847558107-00234

Prideaux, B., Atkinson, S.J., Carolan, V.A., Morton, J., & Clench, M.R. (2006). Sample preparation and data interpretation procedures for the examination of xenobiotic compounds in skin by indirect imaging MALDI-MS. International journal of mass spectrometry, 260 (2-3), 243-251. http://doi.org/10.1016/j.ijms.2006.10.011

Newton, J., Parkinson, D., & Clench, M. (2006). Strategies for examination of Alzheimer’s disease amyloid precursor protein isoforms. Analytical and Bioanalytical Chemistry, 385 (4), 692-699. http://doi.org/10.1007/s00216-006-0462-x

Warburton, K.E., Clench, M.R., Ford, M.J., White, J., Rimmer, D.A., & Carolan, V.A. (2005). Characterisation of derivatised monomeric and prepolymeric isocyanates by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and structural elucidation by tandem mass spectrometry. European Journal of Mass Spectrometry, 11 (6), 565-574. http://doi.org/10.1255/ejms.778

Atkinson, S.J., Prideaux, B., Bunch, J., Warburton, K.E., & Clench, M.R. (2005). Imaging Matrix assisted laser desorption ionisation mass spectrometry: A new technique for drug distribution studies. Chimica Oggi, 23 (6), 5-8.

Mullen, A.K., Clench, M.R., Crosland, S., & Sharples, K.R. (2005). Determination of agrochemical compounds in soya plants by imaging matrix-assisted laser desorption/ionisation mass spectrometry. Rapid Communications in Mass Spectrometry, 19 (18), 2507-2516. http://doi.org/10.1002/rcm.2078

Clench, M., & Bunch, J. (2005). Imaging MALDI MS: An alternative to autoradiography for drug distribution studies? Bio Tech International, 17 (2), 20-23.

Bunch, J., Clench, M.R., & Richards, D.S. (2004). Determination of pharmaceutical compounds in skin by imaging matrix-assisted laser desorption/ionisation mass spectrometry. Rapid communications in mass spectrometry, 18 (24), 3051-3060. http://doi.org/10.1002/rcm.1725

Crecelius, A., Clench, M.R., Richards, D.S., & Parr, V. (2004). Quantitative determination of Piroxicam by TLC-MALDI TOF MS. Journal of Pharmaceutical and Biomedical Analysis, 35 (1), 31-39. http://doi.org/10.1016/j.jpba.2003.12.009

Baidoo, E.E.K., Clench, M.R., Smith, R.F., & Tetler, L.W. (2003). Determination of nicotine and its metabolites in urine by solid-phase extraction and sample stacking capillary electrophoresis-mass spectrometry. Journal of chromatography B, 796 (2), 303-313. http://doi.org/10.1016/j.jchromb.2003.08.016

Wang, T., Anderson, D.R., Thompson, D., Clench, M., & Fisher, R. (2003). Studies into the formation of dioxins in the sintering process used in the iron and steel industry. 1. Characterisation of isomer profiles in particulate and gaseous emissions. Chemosphere, 51 (7), 585-594. http://doi.org/10.1016/S0045-6535(02)00784-1

Crecelius, A., Clench, M.R., & Richards, D.S. (2003). TLC-MALDI in pharmaceutical analysis. LC GC Europe, 16 (4), 225-229.

Liu, Q.T., Clench, M.R., & Kinderlerer, J.L. (2002). Monoacylglycerols derived from butter oil by Penicillium roquefortii in suspension cultures. Journal of the Science of Food and Agriculture, 82 (5), 553-558. http://doi.org/10.1002/jsfa.1071

Crecelius, A., Clench, M.R., Richards, D.S., & Parr, V. (2002). Thin-layer chromatography–matrix-assisted laser desorption ionisation–time-of-flight mass spectrometry using particle suspension matrices. Journal of chromatography A, 958 (1-2), 249-260. http://doi.org/10.1016/S0021-9673(02)00391-6

Crecelius, A., Clench, M.R., Richards, D.S., Evason, D., & Parr, V. (2002). Thin-layer chromatography - Postsource-decay matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of small drug molecules. Journal of Chromatographic Science, 40 (10), 614-620. http://doi.org/10.1093/chromsci/40.10.614

Benomar, S.H., Clench, M.R., & Allen, D.W. (2001). The analysis of alkylphenol ethoxysulphonate surfactants by high-performance liquid chromatography, liquid chromatography-electrospray ionisation-mass spectrometry and matrix-assisted laser desorption ionisation-mass spectrometry. Analytica Chimica Acta, 445 (2), 255-267. http://doi.org/10.1016/S0003-2670(01)01280-6

Douce, D.S., Clench, M.R., & Frost, B. (2001). Variations in the estimation of the contribution of environmental tobacco smoke (ETS) to respirable (≤5 μm) indoor air particulates obtained by the use of different analytical methods. Journal of Environmental Monitoring, 3 (3), 295-301. http://doi.org/10.1039/b008212k

Sokmen, M., Allen, D.W., Hewson, A.T., & Clench, M.R. (2001). Photocatalytic oxidative degradation of 2-methylthiophene in suspensions of TiO2: Identification of intermediates and degradation pathways. Journal of Photochemistry and Photobiology A: Chemistry, 141 (1), 63-67. http://doi.org/10.1016/S1010-6030(01)00420-8

Willetts, M., Brown, V.A., & Clench, M.R. (2000). Influence of surface carbon coverage of C1 (TMS) stationary phases on the separation of nonylphenol ethoxylate ethoxymers. Journal of Chromatography A, 903 (1-2), 33-40. http://doi.org/10.1016/S0021-9673(00)00878-5

Crecelius, A., Clench, M.R., Richards, D.S., Mather, J., & Parr, V. (2000). Analysis of UK-224,671 and related substances by thin-layer chromatography-matrix-assisted laser-desorption ionization-time of flight mass spectrometry. Journal of Planar Chromatography - Modern TLC, 13 (2), 76-81.

White, J., Brown, R.H., & Clench, M.R. (1997). Particle beam liquid chromatography mass spectrometry analysis of hazardous agricultural and industrial chemicals. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 11 (6), 618-623. http://doi.org/10.1002/(SICI)1097-0231(199704)11:6<618::AID-RCM731>3.0.CO;2-8

Douce, D.S., Clench, M.R., Cooke, M., & Wang, J. (1997). Evidence for the adsorption of nitrated polycyclic aromatic hydrocarbons by tree bark. Journal of Chromatography A, 786 (2), 275-283. http://doi.org/10.1016/S0021-9673(97)00602-X

Wang, J., Wang, T., Zhen, Z., Luo, Y., Clench, M.R., & Mowthorpe, D.J. (1997). The influence of the temperature of blackbody for calibrating ftir system on the instrument response function. Spectroscopy Letters, 30 (4), 783-791. http://doi.org/10.1080/00387019708006698

Wang, J., Clench, M.R., Wang, T., Zuoru, C., Luo, Y., Mowthorpe, D.J., & Cooke, M. (1997). The quantitative analysis of multicomponent gaseous mixtures of organic compounds by FT-IR. Spectroscopy Letters, 30 (1), 99-106. http://doi.org/10.1080/00387019708002593

White, J., Brown, R.H., & Clench, M.R. (1997). Particle beam liquid chromatography/mass spectrometry analysis of hazardous agricultural and industrial chemicals. Rapid Communications in Mass Spectrometry, 11 (6), 618-623. http://doi.org/10.1002/(SICI)1097-0231(199704)11:6<618::AID-RCM731>3.0.CO;2-8

Scullion, S.D., Clench, M.R., Cooke, M., & Ashcroft, A.E. (1996). Determination of surfactants in surface water by solid-phase extraction, liquid chromatography and liquid chromatography-mass spectrometry. Journal of Chromatography A, 733 (1-2), 207-216. http://doi.org/10.1016/0021-9673(95)01188-9

Allen, D.W., Clench, M.R., Hewson, A.T., & Sokmen, M. (1996). A Clean One-step Synthesis of 2-Hydroxythiophene[Thiophen-2(5H)-one] by a Fenton-like [Copper(II)-Hydrogen Peroxide] Oxidation of Thiophene under Aqueous Conditions. Journal of Chemical Research - Part S, (5), 242-243.

Furness, J.F., Weekes, A., Clench, M., Wolff, K., Barnes, I., Hay, A.W.M., & Cooke, M. (1994). The determination of methadone and metabolites in human urine by HPLC with ultraviolet, and particle beam mass spectrometric detection. Journal of Liquid Chromatography, 17 (20), 4431-4444. http://doi.org/10.1080/10826079408013627

Allen, D.W., Clench, M.R., Crowson, A., Leathard, D.A., & Saklatvala, R. (1994). Characterisation of electron beam generated transformation products of irganox 1010 by particle beam liquid chromatography-mass spectrometry with on-line diode array detection. Journal of Chromatography A, 679 (2), 285-297. http://doi.org/10.1016/0021-9673(94)80571-7

Allen, D.W., Clench, M.R., Crowson, A., & Leathard, D.A. (1993). Identification by particle-beam liquid chromatography-mass spectrometry of transformation products of the antioxidant Irganox 1330 in food-contact polymers subjected to electron-beam irradiation. Journal of Chromatography A, 629 (2), 283-290. http://doi.org/10.1016/0021-9673(93)87042-K

Allen, D.W., Clench, M.R., Crowson, A., & Leathard, D.A. (1993). Characterisation of solvent-extractable transformation products of high molecular weight hindered phenols in polypropylene subjected to ionising radiation in air or to thermal ageing. Polymer Degradation and Stability, 39 (3), 293-297. http://doi.org/10.1016/0141-3910(93)90004-3

Mills, G.A., Walker, V., Clench, M.R., & Parr, V.C. (1988). Analysis of urinary organic acids by plasmaspray Liquid chromatography/mass spectrometry. Biological Mass Spectrometry, 16 (1-12), 259-261. http://doi.org/10.1002/bms.1200160149

Clench, M.R., Garner, G.V., Gordon, D.B., & Barber, M. (1985). Surface effects in FAB mapping of proteins and peptides. Biological Mass Spectrometry, 12 (7), 355-357. http://doi.org/10.1002/bms.1200120708

Conference papers

Deininger, L., Schramm, J., Langenburg, G., Clench, M.R., Sears, V., Sammon, C., & Francese, S. (2017). BOTTOM UP PROTEOMICS FOR DETECTION AND PROVENANCE DETERMINATION OF BLOOD IN STAINS AND FINGERMARKS. FORENSIC SCIENCE INTERNATIONAL, 277, 87.

Harvey, A., Cole, L., Clench, M., Cross, N., & Smith, D. (2015). MALDI-IMS-MSI for the Analysis of 3D Tissue-Engineered Psoriatic Skin Models. TISSUE ENGINEERING PART A, 21, S163.

Cole, L., Selvan, A., Wright, C., Reed, H., & Clench, M. (2014). Communication of medical images to diverse audiences using multiple imaging modalities'. In BMSS Annual Meeting 2014, Alderley Park Conference Centre, Macclesfield, Cheshire, 1 April 2014 - 2 April 2014.

Battle, R., Woodroofe, M.N., Clench, M., Bradshaw, R., Harrison, P., & Clark, B. (2013). A bioinformatics and proteomic approach for the identification of peptides derived from HLA class I molecules and presented by HLA-A*02. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 40 (5), 414.

Battle, R., Woodroofe, M.N., Clench, M., & Clark, B. (2013). HLA-Class I leader peptide sequence mismatches between renal transplant donors and recipients are associated with a reduction in allograft function within the first 12 months post transplant. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 40 (5), 403.

Dahlawi, H., Jordan-Mahy, N., Clench, M.R., McDougall, G.J., & Le Maitre, C. (2012). Impact of Anthocyanin Chemical Structure Found in Pomegranate Juice on Leukaemia Treatment. JOURNAL OF PATHOLOGY, 228, S37.

Zaini, R., Haywood, S., Brandt, K., Clench, M.R., Cross, N., & Le Maitre, C. (2012). Synergistic Action of Falcarinol on Induction of Apoptosis on Human Lymphoid Leukaemia Cell Lines. JOURNAL OF PATHOLOGY, 228, S38.

Seppala, U., Francese, S., Turilazzi, S., Moneti, G., Clench, M., & Barber, D. (2012). In Situ Imaging Of Honeybee (Apis Mellifera) Venom Components From Immunotherapy Preparations. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 129 (2), AB113. http://doi.org/10.1016/j.jaci.2011.12.554

Bird, N.C., Atkinson, S.J., Clench, M.R., Mangnall, D., & Majeed, A.W. (2007). Lipid profiles at the tumour: liver margins in colorectal liver metastasis by imaging MALDI-MS. CLINICAL & EXPERIMENTAL METASTASIS, 24 (4), 275.

Southern, L.J., Hughes, H., Lawford, P.V., Clench, M.R., & Manning, N.J. (2000). Glutaraldehyde-induced cross-links: A study of model compounds and commercial bioprosthetic valves. Journal of Heart Valve Disease, 9 (2), 241-249.

Palmer, M.E., Clench, M.R., Tetler, L.W., & Little, D.R. (1999). Exact mass determination of narrow electrophoretic peaks using an orthogonal acceleration time-of-flight mass spectrometer. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 13 (4), 256-263. http://doi.org/10.1002/(SICI)1097-0231(19990228)13:4<256::AID-RCM459>3.0.CO;2-S

Mowthorpe, S., Clench, M.R., Cricelius, A., Richards, D.S., Parr, V., & Tetler, L.W. (1999). Matrix-assisted laser desorption/ionisation time-of-flight thin layer chromatography mass spectrometry - A rapid method for impurity testing. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 13 (4), 264-270. http://doi.org/10.1002/(SICI)1097-0231(19990228)13:4<264::AID-RCM460>3.0.CO;2-M

Willetts, M., Clench, M.R., Greenwood, R., Mills, G., & Carolan, V. (1999). The determination of non-ionic surfactants in surface waters by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry, 13 (4), 251-255. http://doi.org/10.1002/(sici)1097-0231(19990228)13:4<251::aid-rcm455>3.0.co;2-i

Palmer, M.E., Clench, M.R., Tetler, L.W., & Little, D.R. (1999). Exact mass determination of narrow electrophoretic peaks using an orthogonal acceleration time-of-flight mass spectrometer. Rapid Communications in Mass Spectrometry, 13 (4), 256-263. http://doi.org/10.1002/(SICI)1097-0231(19990228)13:4<256::AID-RCM459>3.0.CO;2-S

Mowthorpe, S., Clench, M.R., Cricelius, A., Richards, D.S., Parr, V., & Tetler, L.W. (1999). Matrix-assisted laser desorption/ionisation time-of-flight/thin layer chromatography/ mass spectrometry - A rapid method for impurity testing. Rapid Communications in Mass Spectrometry, 13 (4), 264-270. http://doi.org/10.1002/(SICI)1097-0231(19990228)13:4<264::AID-RCM460>3.0.CO;2-M

Allen, D.W., Clench, M.R., & Morris, J. (1994). Investigation of the products of oxidation of methylpyridines under aqueous conditions by gas chromatography-mass spectrometry. The Analyst, 119 (5), 903-907. http://doi.org/10.1039/AN9941900903

Book chapters

Francese, S., & Clench, M.R. (2010). MALDI Mass Spectrometry Imaging, a New Frontier in Biostructural Techniques: Applications in Biomedicine. In Shah, H.N., & Gharbia, S.E. (Eds.) Mass Spectrometry for Microbial Proteomics. (pp. 91-116). Wiley: http://doi.org/10.1002/9780470665497.ch5

Theses / Dissertations

Hart, J.R. (2020). Measurement artefacts, ion mobility and other observations in environmental mass spectrometry analyses. (Doctoral thesis). Supervised by Clench, M. http://doi.org/10.7190/shu-thesis-00323

Russo, C. (2019). A Quantitative MALDI-MSI Study of the Movement of Molecules in Biological Systems. (Doctoral thesis). Supervised by Clench, M. http://doi.org/10.7190/shu-thesis-00268

Swales, J. (2018). Mass spectrometry methods for profiling xenobiotic distribution in biofluids and whole tissues. (Doctoral thesis). Supervised by Clench, M. http://doi.org/10.7190/shu-thesis-00089

Brookes, J. (2017). Biological and chemical hazards in water-mix metalworking fluids and mists. (Doctoral thesis). Supervised by Clench, M. http://doi.org/10.7190/shu-thesis-00073

Martin, S. (2016). Identification and mechanistic study of novel drug metabolites by LC-MS. (Doctoral thesis). Supervised by Lenz, E., Clench, M., Francese, S., & Temesi, D.

Batubara, A. (2015). Distribution of anti-cancer drugs in solid tumours studied by MALDI-MSI. (Doctoral thesis). Supervised by Clench, M., & Loadman, P.

Cole, L.M. (2013). Investigation of protein induction in vascular-targeted strategies. (Doctoral thesis). Supervised by Clench, M., & Carolan, V.

Flinders, B. (2013). The use of MALDI-MS for imaging drug disposition in respiratory disease models. (Doctoral thesis). Supervised by Clench, M.

Omar, S.A.S. (2013). Characterisation and bioremediation of soil impacted by Libyan oilfield produced water. (Doctoral thesis). Supervised by Clench, M., & Smith, T.

Hart, P.J. (2012). MALDI-MS investigation of skin and its response to irritants and sensitisers. (Doctoral thesis). Supervised by Clench, M., Woodroofe, N., & Francese, S.

Anderson, D.M.G. (2009). Imaging the distribution of agrochemicals in plants by MALDI-MSI. (Doctoral thesis). Supervised by Clench, M.

Earnshaw, C.J. (2009). Sample preparation methodologies for MALDI-MS imaging and related topics. (Doctoral thesis). Supervised by Clench, M.

Trim, P.J. (2009). MALDI-MS imaging for direct drug distribution analysis. (Doctoral thesis). Supervised by Clench, M.

Djidja, M.-.C. (2009). Examination of tumour tissues by direct MALDI-mass spectrometry imaging and profiling. (Doctoral thesis). Supervised by Clench, M., & Carolan, V.

Atkinson, S.J. (2008). Fundamental aspects of imaging matrix assisted laser desorption ionisation mass spectrometry. (Doctoral thesis). Supervised by Clench, M.

Denney, H.A. (2008). Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis. (Doctoral thesis). Supervised by Woodroofe, N., Bunning, R., & Clench, M.

Prideaux, B. (2007). Application of imaging MALDI-MS to the determination of hazardous compounds in skin. (Doctoral thesis). Supervised by Clench, M.

Warburton, K.E. (2006). Determination of isocyanates on industrial sampling filters by MALDI-MS and associated studies. (Doctoral thesis). Supervised by Clench, M., White, J., & Rimmer, D.

Bunch, J. (2005). Detection and imaging of pharmaceutical compounds in skin by MALDI-MS. (Doctoral thesis). Supervised by Clench, M.

Benke, P.I. (2004). Development and applications of electrically driven separation methods. (Doctoral thesis). Supervised by Clench, M., Carolan, V., & Tetler, L.

Newton, J.R.A. (2004). Strategies for the examination of Alzheimer's disease amyloid precursor protein isoforms. (Doctoral thesis). Supervised by Parkinson, D., & Clench, M.

Baidoo, E.E.K. (2003). Determination of nicotine and its metabolites by capillary electrophoresis and mass spectrometry. (Doctoral thesis). Supervised by Tetler, L., Smith, B., & Clench, M.

Crecelius, A.C. (2002). Thin layer chromatography-matrix assisted laser desorption ionisation-mass spectrometry of pharmaceutical compounds. (Doctoral thesis). Supervised by Clench, M., & Richards, D.

Delogne, C. (2002). Characterisation of the cross-linking and calcification associated with glutaraldehyde-treated cardic bioprostheses. (Doctoral thesis). Supervised by Clench, M., & Yarwood, J.

Ford, M.J. (2002). Modern mass spectrometric techniques applied to occupational hygiene analysis. (Doctoral thesis). Supervised by Clench, M.

Ellis, D.R. (2002). Development and applications of electrically-driven separation methods. (Doctoral thesis). Supervised by Tetler, L., & Clench, M.

Benomar, S.H. (2001). The analysis of salt resistant surfactants used in enhanced oil recovery. (Doctoral thesis). Supervised by Clench, M., & Allen, D.

Palmer, M. (2000). Development and application of capillary electrophoresis/mass spectrometry. (Doctoral thesis). Supervised by Tetler, L., Clench, M., & Hague, J.

White, J. (2000). The determination of trace organic micro-pollutants by particle beam liquid chromatography mass spectrometry. (Doctoral thesis). Supervised by Clench, M., & Hague, J.

Posters

Wright, C., Reed, H., Partridge, R., Cole, L., Selvan, A., & Clench, M. (2014). Communication of multi-modal imaging:MRI, MSI, and histology. Presented at: BCISMRM, Edinburgh, 2014

Postgraduate supervision

Jerry Hart - Ion Statistics and Other Measurement Artefacts in MS-based Ultratrace Environmental Analyses

Cristina Russo - Imaging the transport and biotransformation of molecules across biological membranes

Lucy Flint - Biopharmaceutical Quantification by Mass Spectrometry Imaging


Previous supervision:

Jodi Brookes - Identification of Potential Chemical and Biological Biohazards in Water Mix Metal Working Fluids

Dr Laura Cole - Postdoctoral Researcher in Analytical Mass Spectrometry and Oncological proteomic analysis

Scott Martin - Identification and Mechanistic Study of Several Novel Products Found By LC-MS During Drug Metabolism Studies

Christopher Mitchell - Examination of Pharmaco-Toxicodynamic Responses in Skin By MALDI-MS Imaging and Profiling

John Swales - Ionisation Methods for Kinetic Profiling of Drugs in Biofluids and Whole Tissues

Afnan Batubara - Studies of the distribution of anti-cancer drugs in solid tumours by Mass Spectrometry Imaging

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