Micronutrient Intervention Effects on Cognitive Outcomes in Post-Acute and Chronic TBI
Outline of research project
The research will investigate the potential role of vitamin and mineral interventions in the amelioration of secondary cascade processes occurring after traumatic brain injury (TBI), concentrating on two reparative ‘windows’ when intervention may be most effective in impacting the severity of cognitive sequelae. Two groups, one post-acute and one chronic (one year post-injury), will be investigated. Research will focus on the domains of memory, executive function and social cognition; functions particularly affected following traumatic brain injury. Previous research has demonstrated improvements in these domains following micronutrient interventions both in normal and selected clinical populations, however no current research has utilised such interventions in mild to moderate post-acute or chronic TBI.
Buell, J. S., Scott, T. M., Dawson-Hughes, B., Dallal, G. E., Rosenberg, I. H., Folstein, M. F., and Tucker, K. L. (2009). Vitamin D is associated with cognitive function in elders receiving home health services. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 64(8), 888-895.
Haskell, C. F., Robertson, B., Jones, E., Forster, J., Jones, R., Wilde, A., Kennedy, D. O. (2010). Effects of a multi‐vitamin/mineral supplement on cognitive function and fatigue during extended multi‐tasking. Human Psychopharmacology: Clinical and Experimental, 25(6), 448-461.
Przybelski, R. J., and Binkley, N. C. (2007). Is vitamin D important for preserving cognition? A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function. Archives of Biochemistry and Biophysics, 460(2), 202-205.
Scrimgeour, A. G., and Condlin, M. L. (2014). Nutritional treatment for traumatic brain injury. Journal of Neurotrauma, 31(11), 989-999.
Tupe, R. P., and Chiplonkar, S. A. (2009). Zinc supplementation improved cognitive performance and taste acuity in Indian adolescent girls. Journal of the American College of Nutrition, 28(4), 388-396.
Director of studies
Dr Lynne Barker