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Dr Alison Cross BSc, PhD, FHEA

Senior Lecturer in Biosciences


Summary

Alison was appointed as a lecturer at Sheffield Hallam University following a PhD in neuroimmunology, and six years post-doctoral research in Neuroscience at Sheffield Hallam University. Her specialist teaching areas related to her research are immunology and neurological disease and she also teaches a wide range of biological subjects. Her research focuses on the pathogenesis of multiple sclerosis and stroke.

Teaching

Extended degree, BSc Biosciences Programme and MSc Biosciences Programme

Research

Dr Stuart Allen, University of Manchester
Dr David Buttle, Sheffield University
Dr Kirsty Harkness
Royal Hallamshire Hospital, Sheffield

Publications

Journal articles

Binch, A.L.A., Cole, A.A., Breakwell, L.M., Michael, A.L.R., Chiverton, N., Creemers, L.B., ... Le Maitre, C. (2015). Nerves are more abundant than blood vessels in the degenerate human intervertebral disc. Arthritis research & therapy, 17 (1), 370. http://doi.org/10.1186/s13075-015-0889-6

Phillips, K.L.E., Cullen, K., Chiverton, N., Michael, A.L.R., Cole, A.A., Breakwell, L.M., ... Le Maitre, C.L. (2015). Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes. Osteoarthritis and Cartilage, 23 (7), 1165-1177. http://doi.org/10.1016/j.joca.2015.02.017

Binch, A.L.A., Cole, A.A., Breakwell, L.M., Michael, A.L.R., Chiverton, N., Creemers, L.B., ... Le Maitre, C. (2015). Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc. Oncotarget, 6 (21), 18338-18354. http://doi.org/10.18632/oncotarget.4274

Binch, A.L.A., Cole, A.A., Breakwell, L.M., Michael, A., Chiverton, N., Cross, A.K., & Le Maitre, C.L. (2014). Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration. Arthritis research & therapy, 16 (5), 416. http://arthritis-research.com/content/16/4/416

LA Binch, A., Cole, A.A., Breakwell, L.M., Michael, A.L.R., Chiverton, N., Cross, A.K., & Le Maitre, C. (2014). Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration. Arthritis Research and Therapy, 16. http://doi.org/10.1186/s13075-014-0416-1

Bradford, C.M., Ramos, I., Cross, A.K., Haddock, G., McQuaid, S., Nicholas, A.P., & Woodroofe, M.N. (2014). Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis. Journal of Neuroimmunology, 273 (1-2), 85-95. http://doi.org/10.1016/j.jneuroim.2014.05.007

Binch, A., Cross, A., & Le Maitre, C. (2014). The regulation of nerve and blood vessel ingrowth in aneural and avascular intervertebral disc and articular cartilage. OA Arthritis, 2 (1), 4. http://www.oapublishinglondon.com/article/1286#Authors%20affiliations

Wang, J., Tian, Y., Phillips, K.L.E., Chiverton, N., Haddock, G., Bunning, R., ... Risbud, M.V. (2013). Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. Arthritis & rheumatism, 65 (3), 832-842. http://doi.org/10.1002/art.37819

Phillips, K.L.E., Chiverton, N., Michael, A.L.R., Cole, A.A., Breakwell, L.M., Haddock, G., ... Le Maitre, C.L. (2013). The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc. Arthritis research & therapy, 15 (6), R213. http://doi.org/10.1186/ar4408

Wang, H., Tian, Y., Wang, J., Phillips, K.L.E., Binch, A.L.A., Dunn, S., ... Risbud, M.V. (2013). Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. The Journal of biological chemistry, 288 (23), 16761-74. http://doi.org/10.1074/jbc.M112.446633

Frentzou, G., Bradford, C., Harkness, K.A., Haddock, G., Woodroofe, N.W., & Cross, A. (2012). IL-1β Down-Regulates ADAMTS-13 mRNA Expression in Cells of the Central Nervous System. Journal of Molecular Neuroscience, 46 (2), 343-351. http://doi.org/10.1007/s12031-011-9591-6

Bradford, C.M., Cross, A., Haddock, G., Woodroofe, N.W., & Sharrack, B. (2011). Citrullination of CNS proteins in the pathogenesis of multiple sclerosis. Future Neurology, 6 (4), 521-530. http://doi.org/10.2217/fnl.11.30

Reid, M.J., Cross, A.K., Haddock, G., Allan, S.M., Stock, C.J., Woodroofe, M.N., ... Bunning, R.A.D. (2009). ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat. Neuroscience letters, 452 (3), 252-257. http://doi.org/10.1016/j.neulet.2009.01.058

Bradford, C.M., Cross, A.K., Haddock, G., & Woodroofe, M.N. (2009). Citrullination in MS: potential for a new diagnostic test. British journal of neuroscience nursing, 5 (1), 1-13. http://www.bjnn.co.uk/cgi-bin/go.pl/library/abstract.html?uid=37804

Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J.T., Bunning, R.A., ... Woodroofe, M.N. (2007). Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat. Biochemical Society Transactions, 35 (4), 692. http://doi.org/10.1042/BST0350692

Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A., ... Woodroofe, N. (2006). ADAMTS -1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. Brain research, 1088 (1), 19-30. http://doi.org/10.1016/j.brainres.2006.02.136

Cross, A.K., Haddock, G., Surr, J., Plumb, J., Buttle, D.J., & Woodroofe, N. (2005). Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis. Journal of autoimmunity, 26 (1), 16-23. http://doi.org/10.1016/j.jaut.2005.09.026

Haddock, G., Cross, A.K., Plumb, J., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2005). Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter. Multiple Sclerosis, 12 (4), 386-396. http://doi.org/10.1191/135248506ms1300oa

Plumb, J., McQuaid, S., Cross, A.K., Surr, J., Haddock, G., Bunning, R.A.D., & Woodroofe, M.N. (2005). Upregulation of ADAM-17 expression in active lesions in multiple sclerosis. Multiple Sclerosis, 12 (4), 375-385. http://doi.org/10.1191/135248506ms1276oa

Plumb, J., Cross, A.K., Surr, J., Haddock, G., Smith, T., Bunning, R.A.D., & Woodroofe, M.N. (2005). ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 164 (1-2), 1-9. http://doi.org/10.1016/j.jneuroim.2005.02.021

Cross, A.K., & Woodroofe, M.N. (2001). Immunoregulation of microglial functional properties. Microscopy Research and Technique, 54 (1), 10-17. http://doi.org/10.1002/jemt.1115

Woodroofe, N., Cross, A.K., Harkness, K., & Simpson, J.E. (2000). The role of chemokines in the pathogenesis of multiple sclerosis. Advances in Experimental Medicine and Biology, 468, 135-150.

Cross, A.K., & Woodroofe, M.N. (1999). Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro. GLIA, 28 (3), 183-189. http://doi.org/10.1002/(SICI)1098-1136(199912)28:3<183::AID-GLIA2>3.0.CO;2-3

Cross, A.K., & Woodroofe, M.N. (1999). Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro. GLIA, 28 (3), 183-189. http://doi.org/10.1002/(SICI)1098-1136(199912)28:3<183::AID-GLIA2>3.0.CO;2-3

Cross, A.K., & Woodroofe, M.N. (1999). Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. JOURNAL OF NEUROSCIENCE RESEARCH, 55 (1), 17-23. http://doi.org/10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3>3.0.CO;2-J

Cross, A.K., & Woodroofe, M.N. (1999). Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. Journal of Neuroscience Research, 55 (1), 17-23. http://doi.org/10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3>3.0.CO;2-J

Conference papers

Abuneeza, E., Cross, A., Haddock, G., Bunning, R., & Woodroofe, N. (2014). Expression of ADAMTS-9 in the central nervous system in multiple sclerosis and its relationship to cleavage of aggrecan and versican. Journal of Neuroimmunology, 275 (1-2), 131-132. http://doi.org/10.1016/j.jneuroim.2014.08.353

Phillips, K.L.E., Chiverton, N., Cole, A., Michael, A., Breakwell, L., Haddock, G., ... Le Maitre, C.L. (2012). Interleukin-1 Regulates Chemokine Expression in the Human Intervertebral Disc. JOURNAL OF PATHOLOGY, 228, S30.

Estevao, A.C.B., Phillips, K.L.E., Chiverton, N., Cole, A., Michael, A., Breakwell, L., ... Le Maitre, C.L. (2012). CXCL1, CXCL2 and CXCL3 in the Pathogenesis of Intervertebral Disc Degeneration. JOURNAL OF PATHOLOGY, 228, S30.

Phillips, K.L.E., Chiverton, N., Cole, A., Michael, A., Breakwell, L., Haddock, G., ... Le Maitre, C.L. (2012). Chemokines and their Receptors in the Human Intervertebral Disc. JOURNAL OF PATHOLOGY, 228, S30.

Gibrel, G., Cross, A.K., Haddock, G., Buttle, D.J., & Bunning, R.A.D. (2012). The role of ADAMTSs and versican cleavage in multiple sclerosis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 93 (4), A11.

Phillips, K.L.E., Chiverton, N., Bunning, R.D., Haddock, G., Cross, A.K., & Le Maitre, C.L. (2012). CYTOKINE AND CHEMOKINE EXPRESSION PROFILE IN HUMAN INTERVERTEBRAL DISC DEGENERATION. RHEUMATOLOGY, 51, 147.

Gibrel, G., Cross, A.K., Haddock, G., Buttle, D.J., & Bunning, R.A.D. (2011). The expression and modulation of ADAMTS-1 and TIMP-3 in neuronal SHSY-5Y cells and CNS tissue. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 92 (3), A13.

Frentzou, G.A., Kamara, C., Harkness, K.A., Haddock, G., Doyle, C., Taylor, M., ... Randall, M. (2010). REDUCED ADAMTS-13 ACTIVITY LEVELS IN PARTIAL ANTERIOR CIRCULATION TRANSIENT ISCHAEMIC ATTACK PATIENTS COMPARED TO NONSTROKE CONTROLS. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 81 (11), E69. http://doi.org/10.1136/jnnp.2010.226340.207

Haddock, G., Cross, A.K., Allan, S., Bunning, R.A.D., Buttle, D.J., & Woodroofe, M.N. (2007). Changes in brain expression of chondroitin sulphate proteoglycans following transient middle cerebral artery occlusion in the rat. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 88 (6), A92.

Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J., Bunning, R.A.D., ... Woodroofe, M.N. (2007). Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat. Biochemical Society Transactions, 35 (4), 692-694. http://doi.org/10.1042/BST0350692

Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A.D., ... Woodroofe, M.N. (2006). ADAMTS-1 and-4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by cytokines in astrocytes and endothelial cell cultures. JOURNAL OF NEUROIMMUNOLOGY, 178, 249.

Reid, M.J., Allan, S., Cross, A.K., Woodroofe, M.N., Buttle, D.J., & Bunning, R.A.D. (2006). ADAMTS-9 is upregulated at the mRNA level following middle cerebral artery occlusion in rats. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 87 (1), A28.

Reid, M.J., Cross, A.K., Woodroofe, M.N., Buttle, D.J., & Bunning, R.A.D. (2005). Pro-inflammatory cytokines modulate a disintegrin and metalloproteinase domain with thrombospondin motif S-9 mRNA expression in human glial cell lines. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 86 (6), A81-A82.

Haddock, G., Cross, A.K., Bunning, R.A.D., Plumb, J., Surr, J., Buttle, D.J., ... Woodroofe, M.N. (2004). Expression of ADAMTS-1, -4 -5 and TIMP-3 in different stages of experimental autoimmune encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 58.

Haddock, G., Cross, A.K., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2003). Expression of ADAMTS-1,-4-5 and TIMP-3 in central nervous system cell lines: Possible role in CNS physiology and pathology. GLIA, 33.

Book chapters

Bradford, C., Nicholas, A.P., Cross, A.K., & Woodroofe, N. (2013). Deimination in Multiple Sclerosis and experimental autoimmune encephalomyelitis. In Nicholas, A.P., & Bhattacharya, S.K. (Eds.) Protein deimination in human health and disease. (pp. 165-185). Springer: http://doi.org/10.1007/978-1-4614-8317-5_10

Theses / Dissertations

Abuneeza, E. (2015). Changes in chondroitin sulphate proteoglycan in multiple sclerosis : A role for ADAMTS-9. (Doctoral thesis). Supervised by Woodroofe, N., Bunning, R., Cross, A., & Haddock, G.

Phillips, K. (2013). Cytokines and chemokines in the pathogenesis of low back pain. (Doctoral thesis). Supervised by Le Maitre, C., Cross, A., Bunning, R., & Haddock, G.

Gibrel, G.G.F. (2012). The role of ADAMTS-1, -4 and -5 in multiple sclerosis. (Doctoral thesis). Supervised by Bunning, R., Cross, A., Haddock, G., & Buttle, D.

Posters

Hanson, F., Cross, A., Allen, K., & Campbell, S. (2020). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: Cold Spring Harbor meeting: Translational Control (Virtual), Cold Spring Harbor Laboratories

Hanson, F., Allen, K., Cross, A., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: XIV European Meeting on Glial Cells in Health and Disease, Porto, Portugal

Hanson, F., Cross, A., Allen, K., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: Translation UK, University of Glasgow

Hodgson, R., Allen, K., Cross, A., & Campbell, S. (2019). The impact of eIF2B mutations and ISR-modifying drugs on eIF2B localisation. Presented at: Translation UK, University of Glasgow

Postgraduate supervision

The Role Of ADAMTS-1, 4 and 9 in Multiple Sclerosis (MS)

Cytokine regulation of innervation and vascularisation in human intervertebral disc degeneration
The role of citrullination of CNS proteins in multiple sclerosis.
Cytokines and chemokines in the pathogenesis of low back pain
The role of ADAMTS-1, 4, 5, 9 and ADAM-17 in multiple sclerosis

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