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Liam Bourke PhD

Professor of Cancer Research

Summary

I am a scientist working in clinical trials of oncology outcomes, evidence synthesis and trials innovation.  

Large projects include the NIHR funded STAMINA programme, the NIHR funded SURECAN programme and CRUK PANTERA trial. 

I have sat on international clinical cancer guidelines committees (2016-2018 EAU prostate cancer panel), won national cancer research awards (2017 CRUK inaugural patient involvement research prize) and generated over £6million of research funding. 

You can read my work in many of the world's leading clinical publications e.g. the BMJ, European Urology, NEJM, Cochrane database, Health Technology Assessment and International Journal of Epidemiology.

  • Research

    • Centre for Sport and Exercise Science

    CRUK PANTERA
    NIHR STAMINA
    NIHR SURECAN

  • Publications

    Turner RR, Steed L, Quirk H, Greasley RU, Saxton JM, Taylor SJ, Rosario DJ, Thaha MA, Bourke L. Interventions for promoting habitual exercise in people living with and beyond cancer. Cochrane Database Syst Rev. 2018 Sep 19;9:CD010192. doi: 10.1002/14651858.CD010192.pub3.

    L. Bourke, R. Stevenson, R. Turner, R. Hooper, P. Sasieni, R. Greasley, D. Morrissey, M. Loosemore, A. Fisher, H. Payne, S. J. C. Taylor & D. J. Rosario. (2018) Exercise training as a novel primary treatment for localised prostate cancer: a multi-site randomised controlled phase II study. Scientific Reports, 8: 8374 doi:10.1038/s41598-018-26682-0.

    Catto JWF, Khetrapal P, Ambler G, Sarpong R, Potyka I, Khan S, Tan M, Feber A, Bourke L, Aidan P. Noon AP , Dixon Sf, Goodwin a, Williams NW, Rowe E, Kouparis A, John McGrath J, Brew-Graves C, Kelly JD. (2018) Multidomain Quantitative Recovery Following Radical Cystectomy for Patients Within the Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion Versus Open Radical Cystectomy Randomised Controlled Trial: The First 30 Patients. European Urology, DOI: https://doi.org/10.1016/j.eururo.2018.05.008

    N. Mottet (Chair), R.C.N. van den Bergh, E. Briers (Patient Representative), L. Bourke, P. Cornford (Vice-chair), M. De Santis, S. Gillessen, A. Govorov, J. Grummet, A.M. Henry, T.B. Lam, M.D. Mason, H.G. van der Poel, T.H. van der Kwast, O. Rouvière, T. Wiegel (2018) European Association of Urology Prostate Cancer Guidelines. Available at http://uroweb.org/guideline/prostate-cancer/

    Mottet N, De Santis M, Briers E, Bourke L, Gillessen S, Grummet JP, Lam TB, van der Poel HG, Rouvière O, van den Bergh RCN, Cornford P.(2017) Updated Guidelines for Metastatic Hormone-sensitive Prostate Cancer: Abiraterone Acetate Combined with Castration Is Another Standard. European Urology in press DOI: http://dx.doi.org/10.1016/j.eururo.2017.09.029

    Lardas, M, Liew M, van den Bergh R, Santis M, Bellmunt J, Van den Broeck T, Cornford P, Cumberbatch MG, Fossati N, Gross T, Henry A, Michel Bolla M, Briers E, Joniau S, Lam TB, Mason M, Mottet N, van der Poel H, Rouvière O, Schoots IG, Wiegel T, Willemse P, Yuhong Yuan C and Bourke L. (2017) Quality of Life Outcomes after Primary Treatment for Clinically Localised Prostate Cancer: a Systematic Review. European Urology, 72(6):869-885.

    Gilbert S, Tew G, Fairhurst C, Bourke L, Saxton J, Winter EM and Rosario D (2016). Effects of a lifestyle intervention on endothelial function in men on long-term androgen deprivation therapy for prostate cancer. British Journal of Cancer; Jan 14, doi: 10.1038/bjc.2015.479 (Impact factor 5.6)

    Hooper R and Bourke L. (2015) Cluster randomised trials with repeated cross-sections: some alternatives to parallel group designs. BMJ;350:h2925

    Bourke L, Boorjian SA, Briganti A, Klotz L, Mucci L, Resnick ML, Rosario DJ, Skolarus T, Penson D. (2015) Invited international collaborative review: survivorship and improving quality of life in men with prostate cancer. European Urology, doi: 10.1016/j.eururo.2015.04.023.

    Hooper R and Bourke L. (2014) Dog-leg trials: an alternative to cross-over trials in relatively stable populations. International Journal of Epidemiology, 43(3):930-6.
    Rosario D, Bourke L, Keating N. (2013) Androgen deprivation therapy and cardiovascular harm - are all men created equal? European Urology, Mar;65(3):574-6.

    Bourke L, Gilbert S, Hooper R, Steed L, Joshi M, Catto J, Saxton J, Rosario D. (2013) Lifestyle changes for improving disease specific quality of life in sedentary men on long term androgen deprivation therapy for advanced prostate cancer. A randomised controlled trial. European Urology, 65(5):865-72.

    Bourke L, Kirkbride P, Hooper R, Rosario AJ, Chico T, Rosario DJ. (2013) Endocrine therapy in prostate cancer: time for reappraisal of risks, benefits and cost-effectiveness? British Journal of Cancer, 108(1):9-13.

    Bourke L, Rosario D, Copeland J, Taylor S. (2012) Physical activity for cancer survivors. BMJ 2012;344:d7998. (Impact factor 17.5)
    Bourke L, Copeland R, Rosario D. (2011) Weight loss and exercise in obese older adults. New England Journal of Medicine 23;364(25):2466-7.

    A list of publications is available from the institutional repository, SHURA

    Gilbert S, Tew G, Fairhurst C, Bourke L, Saxton J, Winter EM and Rosario D (2016). Effects of a lifestyle intervention on endothelial function in men on long-term androgen deprivation therapy for prostate cancer. British Journal of Cancer; Jan 14, doi: 10.1038/bjc.2015.479

    Bourke L, Smith D, Steed L, Hooper R, Catto J, Albertsen PC, Tombal B, Payne HA, Rosario DJ. (2015) Exercise interventions for men with prostate cancer. European Urology. DOI: 10.1016/j.eururo.2015.10.047.

    Hooper R and Bourke L. (2015) Reply: Repeated cross-sections in cluster randomised trials. BMJ 350

    Bourke L, Boorjian SA, Briganti A, Klotz L, Mucci L, Resnick ML, Rosario DJ, Skolarus T, Penson D. (2015) Invited international collaborative review: survivorship and improving quality of life in men with prostate cancer. European Urology, doi: 10.1016/j.eururo.2015.04.023.

    Bourke L, Dahm P, Rosario D. (2014) Progress towards embracing exercise training as an integral part of prostate cancer treatment. Journal of Clinical Oncology

    Bourke L, Rosario D, Steed L, Taylor SJC. (2014) Reply: Interventions to improve exercise behaviour in sedentary people living with and beyond cancer: a systematic review. British Journal of Cancer, doi: 10.1038/bjc.2014.249

    Hooper R and Bourke L. (2014) Dog-leg trials: an alternative to cross-over trials in relatively stable populations. International Journal of Epidemiology, 43(3):930-6.

    Rosario D, Bourke L, Keating N. (2013) Androgen deprivation therapy and cardiovascular harm - are all men created equal? European Urology, Mar;65(3):574-6.

    Bourke L, Gilbert S, Hooper R, Steed L, Joshi M, Catto J, Saxton J, Rosario D. (2013) Lifestyle changes for improving disease specific quality of life in sedentary men on long term androgen deprivation therapy for advanced prostate cancer. A randomised controlled trial. European Urology, 65(5):865-72.

    Bourke L, Homer KE, Thaha MA, Steed L, Rosario DJ, Robb KA, Saxton JM, Taylor SJC. (2013) Interventions to improve exercise behaviour in sedentary people living with and beyond cancer: a systematic review. British Journal of Cancer, doi: 10.1038/bjc.2013.750

    Bourke L, Homer KE, Thaha MA, Steed L, Rosario DJ, Robb KA, Saxton JM, Taylor SJC. Interventions for promoting habitual exercise in people living with and beyond cancer. (2013) Cochrane Database of Systematic Reviews, Issue 9. Art. No.: CD010192. DOI: 10.1002/14651858.CD010192.pub2.

    Bourke L, Kirkbride P, Hooper R, Rosario AJ, Chico T, Rosario DJ. (2013) Endocrine therapy in prostate cancer: time for reappraisal of risks, benefits and cost-effectiveness? British Journal of Cancer, 108(1):9-13.

    Rosario DJ, Bourke L. (2013) Reply: Endocrine therapy in prostate cancer: time for reappraisal of risks, benefits and cost-effectiveness? British Journal of Cancer; 108 (10):2194-2194.

    Bourke L, Rosario D, Copeland R, Taylor S. (2013) Republished editorial: Physical activity for cancer survivors: beneficial in the short term, but longer term outcomes are lacking. British Journal of Sports Medicine, 47(9):568.

    Bourke L, Sohanpal R, Nanton R, Crank H, Rosario D, Saxton J. (2012) A qualitative study evaluating experiences of a lifestyle intervention in men with prostate cancer undergoing androgen suppression therapy. Trials, Nov 14;13(1):208.

    Bourke L, Rosario D, Copeland J, Taylor S. (2012) Physical activity for cancer survivors. BMJ 2012;344:d7998.

    Bourke L, Homer KE, Thaha MA, Steed L, Rosario DJ, Robb KA, Saxton JM, Taylor SJC. Interventions for promoting habitual exercise in people living with and beyond cancer [Protocol]. (2013) Cochrane Database of Systematic Reviews, Issue 9. Art. No.: CD010192. DOI: DOI:10.1002/14651858.CD010192.

    Bourke L, Chico T, Albertsen P, Hamdy F, Rosario D. (2012) Cardiovascular risk in androgen suppression: Underappreciated, under-researched and unresolved. Heart; 98(5):345-8.

    Bourke L, Copeland R, Rosario D. (2011) Weight loss and exercise in obese older adults. New England Journal of Medicine 23;364(25):2466-7.

    Bourke L, Thompson G, Gibson DJ, Daley A, Crank H, Adam I, Shorthouse A, Saxton J. (2011). Pragmatic lifestyle intervention in patients recovering from colon cancer: a randomized controlled pilot study. Archives of Physical Medicine and Rehabilitation, 92(5):749-55.

    Selvanayagam M, Thompson C, Taylor SJ, Cummins S, Bourke L. (2012) How might the London 2012 Olympics influence health and the determinants of health? Local newspaper analysis of pre-Games pathways and impacts. BMJ Open, Nov 14;2(6).

    Gilbert SE, Tew GA, Bourke L, Winter EM, Rosario DJ. (2013) Assessment of endothelial dysfunction by flow-mediated dilatation in men on long-term androgen deprivation therapy (ADT) for prostate cancer. Experimental Physiology, doi:10.1113/expphysiol.2013.073353.

    Risi L., Steed L., Round T., Bourke L., Shankleman J. (2013) Primary care delays in diagnosing cancer: what’s causing it and what can we do about it? Journal of the Royal Society of Medicine. 106(11):437-40.

    Meads C, Nyssen OP, Wong G, Steed L, Bourke L, Ross CA, Hayman S, Field V, Lord J, Greenhalgh T, Taylor SJ. (2014) Protocol for an HTA report: Does therapeutic writing help people with long-term conditions? Systematic review, realist synthesis and economic modelling. BMJ Open18;4(2): e004377.

    Book chapter

    Bourke L and Saxton JS (2011). Cancer. Exercise and chronic disease: an evidence-based approach. Routledge, UK. ISBN 978-0-415-49861-6.

  • Other activities

    Working with the European Association of Urology clinical guidelines board as methodology advisor.

  • Media

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