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Liam Bourke PhD

Professor of Cancer Research


Summary

I am a scientist working in clinical trials of oncology outcomes, evidence synthesis and trials innovation.  

Large projects include the NIHR funded STAMINA programme, the NIHR funded SURECAN programme and CRUK PANTERA trial. 

I have sat on international clinical cancer guidelines committees (2016-2018 EAU prostate cancer panel), won national cancer research awards (2017 CRUK inaugural patient involvement research prize) and generated over £6million of research funding. 

You can read my work in many of the world's leading clinical publications e.g. the BMJ, European Urology, NEJM, Cochrane database, Health Technology Assessment and International Journal of Epidemiology.

Research

CRUK PANTERA
NIHR STAMINA
NIHR SURECAN

Publications

Key Publications

Bourke, L., Copeland, R., & Rosario, D. (2011). Weight loss and exercise in obese older adults. New England Journal of Medicine, 364 (25), 2466-2468. http://doi.org/10.1056/NEJMc1104830

Nyssen, O.P., Taylor, S.J.C., Wong, G., Steed, E., Bourke, L., Lord, J., ... Meads, C. (2016). Does therapeutic writing help people with long-term conditions? Systematic review, realist synthesis and economic considerations. Health Technology Assessment, 20 (27), 1-368. http://doi.org/10.3310/hta20270

Bourke, L., Stevenson, R., Turner, R., Hooper, R., Sasieni, P., Greasley, R., ... Rosario, D.J. (2018). Exercise training as a novel primary treatment for localised prostate cancer: a multi-site randomised controlled phase II study. Scientific Reports, 8 (1), 8374. http://doi.org/10.1038/s41598-018-26682-0

Mottet, N., De Santis, M., Briers, E., Bourke, L., Gillessen, S., Grummet, J.P., ... Cornford, P. (2018). Updated Guidelines for Metastatic Hormone-sensitive Prostate Cancer: Abiraterone Acetate Combined with Castration Is Another Standard [Figure presented]. European Urology, 73 (3), 316-321. http://doi.org/10.1016/j.eururo.2017.09.029

Lardas, M., Liew, M., van den Bergh, R.C., De Santis, M., Bellmunt, J., Van den Broeck, T., ... Bourke, L. (2017). Quality of life outcomes after primary treatment for clinically localised prostate cancer: A systematic review. European Urology, 72 (6), 869-885. http://doi.org/10.1016/j.eururo.2017.06.035

Bourke, L., Smith, D., Steed, L., Hooper, R., Carter, A., Catto, J., ... Rosario, D.J. (2015). Exercise for men with prostate cancer : a systematic review and meta-analysis. European Urology, 69 (4), 693-703. http://doi.org/10.1016/j.eururo.2015.10.047

Gilbert, S.E., Tew, G.A., Fairhurst, C., Bourke, L., Saxton, J.M., Winter, E.M., & Rosario, D.J. (2016). Effects of a lifestyle intervention on endothelial function in men on long-term androgen deprivation therapy for prostate cancer. British journal of cancer, 114 (4), 401-408. http://doi.org/10.1038/bjc.2015.479

Hooper, R., & Bourke, L. (2015). Cluster randomised trials with repeated cross-sections: some alternatives to parallel group designs. British Medical Journal (BMJ), 350 (h2925), 1-5. http://doi.org/10.1136/bmj.h2925

Bourke, L., Gilbert, S., Hooper, R., Steed, L.A., Joshi, M., Catto, J.W.F., ... Rosario, D.J. (2014). Lifestyle changes for improving disease-specific quality of life in sedentary men on long-term androgen-deprivation therapy for advanced prostate cancer: a randomised controlled trial. European Urology, 65 (5), 865-872. http://doi.org/10.1016/j.eururo.2013.09.040

Catto, J.W.F., Khetrapal, P., Ambler, G., Sarpong, R., Potyka, I., Khan, S., ... Kelly, J.D. (2018). Multidomain Quantitative Recovery Following Radical Cystectomy for Patients Within the Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion Versus Open Radical Cystectomy Randomised Controlled Trial: The First 30 Patients. European Urology, 74 (4), 531-534. http://doi.org/10.1016/j.eururo.2018.05.008

Turner, R., Steed, L., Quirk, H., Greasley, R.U., Saxton, J.M., Taylor, S.J.C., ... Bourke, L. (2018). Interventions for promoting habitual exercise in people living with and beyond cancer. Cochrane Database of Systematic Reviews, 2018 (9). http://doi.org/10.1002/14651858.CD010192.pub3

Journal articles

Reale, S., Turner, R., Sutton, E., Steed, L., Taylor, S.J.C., Morrissey, D., ... Bourke, L. (2021). Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial). Scientific Reports, 11 (1), 12470. http://doi.org/10.1038/s41598-021-91876-y

Moschopoulou, E., Deane, J., Duncan, M., Ismail, S.A., Moriarty, S., Sarker, S.J., ... Thaha, M. (2021). Measuring quality of life in people living with and beyond cancer in the UK. Supportive Care in Cancer. http://doi.org/10.1007/s00520-021-06105-z

Turner, R., Arden, M., Reale, S., Sutton, E., Taylor, S.J.C., Bourke, L., ... Steed, L. (2021). The development of a theory and evidence-based intervention to aid implementation of exercise into the prostate cancer care pathway with a focus on healthcare professional behaviour, the STAMINA trial. BMC Health Services Research, 21, 273. http://doi.org/10.1186/s12913-021-06266-x

Ibeggazene, S., Turner, R., Rosario, D., & Bourke, L. (2021). Remote interventions to improve exercise behaviour in sedentary people living with and beyond cancer: a systematic review and meta-analysis. BMC Cancer, 21 (1). http://doi.org/10.1186/s12885-021-07989-0

Reale, S., Turner, R.R., Sutton, E., Taylor, S.J.C., Bourke, L., Morrissey, D., ... Steed, L. (2021). Towards implementing exercise into the prostate cancer care pathway: development of a theory and evidence-based intervention to train community-based exercise professionals to support change in patient exercise behaviour (The STAMINA trial). BMC Health Services Research, 21 (1). http://doi.org/10.1186/s12913-021-06275-w

Rosario, D.J., & Bourke, L. (2020). Cardiovascular Disease and the Androgen Receptor: Here We Go Again? European Urology, 77 (2), 167-169. http://doi.org/10.1016/j.eururo.2019.08.017

Quirk, H., Rosario, D., & Bourke, L. (2018). Supportive interventions to improve physiological and psychological health outcomes among patients undergoing cystectomy: A systematic review. BMC Urology, 18, 71. http://doi.org/10.1186/s12894-018-0382-z

Bourke, L., Turner, R., Greasley, R., Sutton, E., Steed, L., Smith, D., ... Rosario, D.J. (2018). A multi-centre investigation of delivering national guidelines on exercise training for men with advanced prostate cancer undergoing androgen deprivation therapy in the UK NHS. PLOS ONE, 13 (7), e0197606. http://doi.org/10.1371/journal.pone.0197606

Greasley, R.U., Turner, R., Collins, K., Brown, J., Bourke, L., & Rosario, D.J. (2018). Treatment in the STAMPEDE era for castrate resistant prostate cancer in the UK: ongoing challenges and underappreciated clinical problems. BMC Cancer, 18 (1), 667. http://doi.org/10.1186/s12885-018-4527-y

Duncan, M., Moschopoulou, E., Herrington, E., Deane, J., Roylance, R., Jones, L., ... Bhui, K. (2017). Review of systematic reviews of non-pharmacological interventions to improve quality of life in cancer survivors. BMJ Open, 7 (11), e015860. http://doi.org/10.1136/bmjopen-2017-015860

Duncan, M., Deane, J., White, P.D., Ridge, D., Roylance, R., Korszun, A., ... Bourke, L. (2017). A survey to determine usual care after cancer treatment within the United Kingdom national health service. BMC Cancer, 17, 186. http://doi.org/10.1186/s12885-017-3172-1

Ruddock, A., Robbins, B., Tew, G., Bourke, L., & Purvis, A. (2017). Practical cooling strategies during continuous exercise in hot environments: a systematic review and meta-analysis. Sports Medicine, 47 (3), 517-532. http://doi.org/10.1007/s40279-016-0592-z

Bourke, L., Bauld, L., Bullen, C., Cumberbatch, M., Giovannucci, E., Islami, F., ... Catto, J.W.F. (2017). E-cigarettes and urologic health: a collaborative review of toxicology, epidemiology, and potential risks. European Urology, 71 (6), 915-923. http://doi.org/10.1016/j.eururo.2016.12.022

Rosario, D.J., Greasley, R., & Bourke, L. (2016). Castration-resistant prostate cancer: preservation of quality of life and well-being. European Urology Focus, 2 (5), 472-475. http://doi.org/10.1016/j.euf.2016.08.011

Bourke, L., Boorjian, S.A., Briganti, A., Klotz, L., Mucci, L., Resnick, M.J., ... Penson, D.F. (2015). Survivorship and improving quality of life in men with prostate cancer. European Urology, 350, h2925. http://doi.org/10.1016/j.eururo.2015.04.023

Bourke, L., Rosario, D.J., Steed, L., & Taylor, S.J.C. (2014). Response to comment on 'Interventions to improve exercise behaviour in sedentary people living with and beyond cancer: A systematic review'. British Journal of Cancer, 111 (12), 2378-2379. http://doi.org/10.1038/bjc.2014.249

Bourke, L., Smith, D., Steed, L., Hooper, R., Catto, J., Albertsen, P.C., ... Rosario, D.J. (2014). Exercise interventions for men with prostate cancer. Cochrane Database of Systematic Reviews, 2014 (8). http://doi.org/10.1002/14651858.CD011251

Bourke, L., Dahm, P.K., & Rosario, D.J. (2014). Progress toward embracing exercise training as an integral part of prostate cancer treatment. Journal of Clinical Oncology, 32 (23), 2517-2518. http://doi.org/10.1200/JCO.2014.55.1879

Meads, C., Nyssen, O.P., Wong, G., Steed, L., Bourke, L., Ross, C.A., ... Taylor, S.J.C. (2014). Protocol for an HTA report: Does therapeutic writing help people with long-term conditions? Systematic review, realist synthesis and economic modelling. BMJ Open, 4 (2). http://doi.org/10.1136/bmjopen-2013-004377

Rosario, D.J., Bourke, L., & Keating, N.L. (2014). Androgen deprivation therapy and cardiovascular harm: Are all men created equal? European Urology, 65 (3), 574-576. http://doi.org/10.1016/j.eururo.2013.11.016

Bourke, L., Homer, K.E., Thaha, M.A., Steed, L., Rosario, D.J., Robb, K.A., ... Taylor, S.J.C. (2014). Interventions to improve exercise behaviour in sedentary people living with and beyond cancer: A systematic review. British Journal of Cancer, 110 (4), 831-841. http://doi.org/10.1038/bjc.2013.750

Hooper, R., & Bourke, L. (2014). The dog-leg: an alternative to a cross-over design for pragmatic clinical trials in relatively stable populations. International Journal of Epidemiology, 43 (3), 930-936. http://doi.org/10.1093/ije/dyt281

Bourke, L., Homer, K.E., Thaha, M.A., Steed, L., Rosario, D.J., Robb, K.A., ... Taylor, S.J.C. (2013). Interventions for promoting habitual exercise in people living with and beyond cancer. Cochrane Database of Systematic Reviews, 2013 (9). http://doi.org/10.1002/14651858.CD010192.pub2

Bourke, L., Rosario, D., Copeland, R., & Taylor, S. (2013). Republished editorial: Physical activity for cancer survivors: Beneficial in the short term, but longer term outcomes are lacking. British Journal of Sports Medicine, 47 (9), 568. http://doi.org/10.1136/bjsports-2012-d7998rep

Rosario, D.J., & Bourke, L. (2013). Reply: Endocrine therapy in prostate cancer: Time for reappraisal of risks, benefits and cost-effectiveness. British Journal of Cancer, 108 (10), 2194. http://doi.org/10.1038/bjc.2013.211

Bourke, L., Kirkbride, P., Hooper, R., Rosario, A.J., Chico, T.J.A., & Rosario, D.J. (2013). Endocrine therapy in prostate cancer: Time for reappraisal of risks, benefits and cost-effectiveness? British Journal of Cancer, 108 (1), 9-13. http://doi.org/10.1038/bjc.2012.523

Round, T., Steed, L., Shankleman, J., Bourke, L., & Risi, L. (2013). Primary care delays in diagnosing cancer: What is causing them and what can we do about them? Journal of the Royal Society of Medicine, 106 (11), 437-440. http://doi.org/10.1177/0141076813504744

Gilbert, S.E., Tew, G.A., Bourke, L., Winter, E.M., & Rosario, D.J. (2013). Assessment of endothelial dysfunction by flow-mediated dilatation in men on long-term androgen deprivation therapy for prostate cancer. Experimental Physiology, 98 (9), 1401-1410. http://doi.org/10.1113/expphysiol.2013.073353

Selvanayagam, M., Thompson, C., Taylor, S.J.C., Cummins, S., & Bourke, L. (2012). How might the London 2012 Olympics influence health and the determinants of health? Local newspaper analysis of pre-Games pathways and impacts. BMJ Open, 2 (6). http://doi.org/10.1136/bmjopen-2012-001791

Bourke, L., Sohanpal, R., Nanton, V., Crank, H., Rosario, D., & Saxton, J. (2012). A qualitative study evaluating experiences of a lifestyle intervention in men with prostate cancer undergoing androgen suppression therapy. Trials, 13 (208). http://doi.org/10.1186/1745-6215-13-208

Bourke, L., Chico, T.J.A., Albertsen, P.C., Hamdy, F.C., & Rosario, D.J. (2012). Cardiovascular risk in androgen suppression: Underappreciated, under-researched and unresolved. Heart, 98 (5), 345-348. http://doi.org/10.1136/heartjnl-2011-300893

Bourke, L., Rosario, D., Copeland, R., & Taylor, S. (2012). Physical activity for cancer survivors : beneficial in the short term, but longer term outcomes are lacking. British Medical Journal (BMJ), 344, 8. http://doi.org/10.1136/bmj.d7998

Bourke, L., Thompson, G., Gibson, D., Daley, A., Crank, H., Adam, I., ... Saxton, J. (2011). Pragmatic lifestyle intervention in patients recovering from colon cancer: a randomized controlled pilot study. Archives of Physical Medicine and Rehabilitation, 92 (5), 749-755. http://doi.org/10.1016/j.apmr.2010.12.020

Bourke, L., Doll, H., Crank, H., Daley, A., Rosario, D., & Saxton, J. (2011). Lifestyle intervention in men with advanced prostate cancer receiving androgen suppression therapy: a feasibility study. Cancer epidemiology, biomarkers and prevention, 20 (5), 647-657. http://doi.org/10.1158/1055-9965.EPI-10-1143

Bourke, L., Tew, G., Milo, M., Crossman, D.C., Saxton, J.M., & Chico, T.J.A. (2010). Study protocol: A randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina. BMC Public Health, 10, 620. http://doi.org/10.1186/1471-2458-10-620

Book chapters

Bourke, L., & Saxton, J.M. (2011). Colorectal, breast and prostate cancer. In Exercise and Chronic Disease: An Evidence-Based Approach. (pp. 364-379). http://doi.org/10.4324/9780203877043

Theses / Dissertations

Gilbert, S.E. (2013). Cardiovascular health in men on androgen deprivation therapy for prostate cancer. (Doctoral thesis). Supervised by Tew, G., Bourke, L., Winter, E., & Rosario, D.

Other activities

Working with the European Association of Urology clinical guidelines board as methodology advisor.

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