Professor Markos Klonizakis BEng (Hons), PGCE, MSc, D.Phil, FHEA
Professor of Vascular and Clinical Physiology
Summary
Following my undergraduate studies at Sheffield Hallam University, and MSc courses in the universities of Leeds and Sheffield Hallam, I completed a DPhil in Microvascular Physiology at the University of Nottingham, joining Hallam in 2013. I have extensive experience in the design, development and implementation of lifestyle interventions aiming to improve physiological and clinical outcomes for pre-clinical and clinical populations. I currently lead the Lifestyle, Exercise and Nutrition Improvement (LENI) Research Group and lead the Health research strand in the SHU-La Trobe University partnership.
About
I am a fellow of Higher Education Academy (having completed a PGCE in Higher Education) and a member of the Publications Committee of the Physiological Society. I have been invited to present my work and chair symposia in many international conferences (such as the 28th World Congress of the International Union of Angiology in Beijing, China in 2018 and FEPS 2019 Meeting of the Federation of European Physiological Societies in Bologna, Italy), having also delivered invited seminars and workshops both in the UK and overseas.
LENI Research Group, which I lead, is currently investigating how lifestyle interventions can reduce disease burden or prevent disease for clinical and pre-clinical populations. For example, we have been assessing if it is feasible to use exercise as an adjunct therapy to compression for patients with venous ulceration (FISCU II; funded by NIHR – Research for Patient Benefit Programme) as well as exploring the effect of e-cigarettes in the vascular physiology of smokers (ISME-NRT; funded by Heart Research UK).
Also of particular interest to myself and the group is the exploration of the effects of regional (e.g., Nordic, Mediterranean) and novelty (e.g., vegan, kefir-based) diets in younger and older groups. This series of projects is being undertaken in collaboration with other U.K. (e.g., Universities of Lincoln and Sheffield) and European (e.g., Aristotle University of Thessaloniki, University of Lille) universities.
I am also quite passionate about the reduction of non-communicable diseases in Black, Asian and Ethnic Minority (BAME) populations, and I am currently leading a network of distinguished academics, BAME organisations and public health organisations and city councils, aiming to address the disparities faced by this population. Finally, another area of interest, is the predictive role of heamatological markers in the disease-outcome of patients with rectal cancer as well as the effect of cancer disease in the patients’ cardiopulmonary and microcirculatory function.
Research
Current projects which I lead include:
- a) "Exploring the effects of a combined exercise programme on pain and fatigue outcomes in people with systemic sclerosis: A large multi-centre randomised controlled trial (EXCEF-SSc)”. Funded by a FOREUM research project grant.
- b) "Rehabilitation Intervention to Support People with Heart Failure (PORIAS-HF).” Funded by a Creating Knowledge SHU grant.
- c) “Exploring the feasibility of implementing a home-based exercise training and compression hosiery intervention in patients with venous ulceration (FISCU II)." Funded by a National Institute of Health Research, Research for Patient Benefit grant.
- d) "Exploring the effect of aquatic exercise on prevention of cardiovascular disease in older adults (ACELA II)." Supported by Sheffield International Venues. I am also a co-investigator in "a 2 x 2 factorial randomised controlled trial of exercise or dilute hypochlorous acid for venous leg ulcers (Factorial 4VLU)", which is funded by Health Research Council of New Zealand and is led by Prof. A. Jull (University of Auckland).
Featured Projects
- Link 1: https://www.leni-research.org/project/quality-of-life-systemic-sclerosis/
- Link 2: https://www.leni-research.org/project/porias-hf
- Link 3: https://www.leni-research.org/project/fiscu-ii
- Link 4: https://www.leni-research.org/project/acela-ii
Collaborators and Sponsors
Active research collaborations in projects, scientific papers and grant applications include:
- i) UK Higher Education Institutions: Northumbria University, University of Sheffield, Queen Mary University of London, University of East Anglia, King’s College London, University of Stirling, Brunel University, University of Newcastle, University of Nottingham, University of Oxford, University of Southampton, Manchester Metropolitan University, University of Teeside, University of Lincoln, University of Bournemouth, Leeds Beckett University.
- ii)Non-UK Higher Education Institutions: Aristotle University of Thessaloniki (Greece), International University of Greece, University of Lille (France), University of Angiers (France), Karolinska Institute (Sweden), University of Plovdiv (Bulgaria), Sapienza University of Rome (Italy), University of Alabama (USA), University of Osijek (Croatia), University of Ljubljana (Slovenia), University of Auckland (New Zealand), University of Tasmania (Australia).
- iii) NHS Organisations: Sheffield Teaching Hospitals NHS FT, Sheffield Health and Social Care NHS FT, Northumbria Healthcare NHS FT, Lancashire Care NHS Foundation FT, Kent Community Health NHS FT, Nottingham CityCare Partnership, Central London Community Healthcare NHS Trust, Leeds Community Healthcare NHS Trust, Royal Brompton & Harefield NHS FT.
For current funders please see Current Research Projects.
Publications
Journal articles
Klonizakis, M., Gumber, A., McIntosh, E., Levesley, M., Horspool, M., & Logan, P. (2023). Testing the feasibility of a co-designed intervention comprising self-managed, home-based exercise training with embedded behavioral support and compression therapy for people with venous leg ulcers, receiving treatment at home (FISCU-II). Clinical and Experimental Dermatology. http://doi.org/10.1093/ced/llad342
Klonizakis, M., Gumber, A., Morley, A., Horspool, M., Mcintosh, E., Levesley, M., ... Logan, P. (2023). Exploring the Feasibility of a Self-Managed Lifestyle Intervention, Based on Exercise and Behaviour Support, as an Adjunct Therapy to Compression: A Sub-Study Focusing on People with Venous Leg Ulcers and Early Neuro-Degenerative Diseases (FISCU-NDD). Healthcare, 11 (20). http://doi.org/10.3390/healthcare11202728
Parkington, T., Maden-Wilkinson, T., Broom, D., Nawaz, S., & Klonizakis, M. (2023). Low-Intensity Resistance Exercise with Blood Flow Restriction for Patients with Claudication: A Randomised Controlled Feasibility Trial. Vascular Medicine, 28 (6), 554-563. http://doi.org/10.1177/1358863X231200250
Klonizakis, M., & Mitropoulos, A. (2023). Assessing the effect of regular swimming exercise on the micro- and macrovascular physiology of older adults (ACELA II study). Frontiers in Physiology, 14. http://doi.org/10.3389/fphys.2023.1223558
Ibeggazene, S., & Klonizakis, M. (2023). Clinical outcomes in intermittent claudication – time for a change? Vasa: journal of vascular diseases, 52 (5). http://doi.org/10.1024/0301-1526/a001087
McIntosh, E., Horspool, M., Levesley, M., Logan, P., & Klonizakis, M. (2023). The co‐design of an exercise‐based, lifestyle intervention for people with venous leg ulcers; a self‐care, expert‐supported strategy for a chronic condition. International Wound Journal. http://doi.org/10.1111/iwj.14117
Anifanti, M., Teloudi, A., Mitropoulos, A., Syrakou, N., Pagkopoulou, E., Triantafyllidou, E., ... Kouidi, E. (2023). Right Ventricular Morphology and Function after Exercise Training in People with Systemic Sclerosis: A Randomized Controlled Pilot Study. Life, 13 (2). http://doi.org/10.3390/life13020545
Parkington, T., Maden-Wilkinson, T., Klonizakis, M., & Broom, D. (2022). Comparative perceptual, affective, and cardiovascular responses between resistance exercise with and without blood flow restriction in older adults. International Journal of Environmental Research and Public Health, 19 (23). http://doi.org/10.3390/ijerph192316000
Mitropoulos, A., Boström, C., Mattsson, M., Kouidi, E., Dimitroulas, T., Liem, S.I.E., ... Klonizakis, M. (2022). Exploring the effects of a combined exercise programme on pain and fatigue outcomes in people with systemic sclerosis: Study protocol for a large European multi-centre randomised controlled trial. Trials, 23. http://doi.org/10.1186/s13063-022-06853-1
Klonizakis, M., Gumber, A., Mcintosh, E., & Brose, L.S. (2022). Medium- and longer-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial. BMC Medicine, 20. http://doi.org/10.1186/s12916-022-02451-9
Mitropoulos, A., Goodwill, S., Copeland, R., & Klonizakis, M. (2022). The relationship between physical activity and severity of covid-19 symptoms in non-hospitalised individuals. European Journal of Public Health. http://doi.org/10.1093/eurpub/ckac097
Usman, J.E., Childs, C., Rogerson, D., & Klonizakis, M. (2022). A systematic review of internet-based interventions for the prevention and self-management of cardiovascular diseases among people of African descent. International Journal of Environmental Research and Public Health, 19 (14). http://doi.org/10.3390/ijerph19148872
Woodward, A., Broom, D., Dalton, C., Metwally, M., & Klonizakis, M. (2022). Supervised aerobic exercise training and increased lifestyle physical activity to reduce cardiovascular disease risk for women with polycystic ovary syndrome: a randomized controlled feasibility trial. Journal of Physical Activity & Health, 19 (6), 436-445. http://doi.org/10.1123/jpah.2022-0103
Rogerson, D., Morar, F.A.A., Young, J., & Klonizakis, M. (2022). No effect of nitrate-rich beetroot juice on microvascular function and blood pressure in younger and older individuals: A randomised, placebo-controlled double-blind pilot study. European Journal of Clinical Nutrition, 76 (10). http://doi.org/10.1038/s41430-022-01115-4
Klonizakis, M., Gumber, A., McIntosh, E., & Brose, L.S. (2021). Short-Term Cardiovascular Effects of E-Cigarettes in Adults Making a Stop-Smoking Attempt: A Randomized Controlled Trial. Biology, 10 (11). http://doi.org/10.3390/biology10111208
Mitropoulos, A., & Klonizakis, M. (2021). Correspondence -Scientific critique on the effects of supervised exercise program and home exercise program in patients with systemic sclerosis: A randomized controlled trial. International Journal of Rheumatic Diseases. http://doi.org/10.1111/1756-185X.14234
Klonizakis, M., Bugg, A., Hunt, B., Theodoridis, X., Bogdanos, D.P., & Grammatikopoulou, M.G. (2021). Assessing the Physiological Effects of Traditional Regional Diets Targeting the Prevention of Cardiovascular Disease: A Systematic Review of Randomized Controlled Trials Implementing Mediterranean, New Nordic, Japanese, Atlantic, Persian and Mexican Dietary Interventions. Nutrients, 13 (9). http://doi.org/10.3390/nu13093034
Jones, G., McIntosh, E., Brose, L.S., & Klonizakis, M. (2021). Participant Experiences of a Quit Smoking Attempt Through Either Nicotine Replacement Therapy (NRT) Methods or the Use of an E-cigarette. J Addict Med, Publis. http://doi.org/10.1097/ADM.0000000000000881
Galan-Lopez, P., Domínguez, R., Gísladóttir, T., Sánchez-Oliver, A.J., Pihu, M., Ries, F., & Klonizakis, M. (2021). Sleep Quality and Duration in European Adolescents (The AdolesHealth Study): A Cross-Sectional, Quantitative Study. Children, 8 (3). http://doi.org/10.3390/children8030188
Jull, A., Wadham, A., Bullen, C., Parag, V., Parsons, J.G.M., Laking, G., ... O'Brien, J. (2021). Prescribed exercise regimen versus usual care and hypochlorous acid wound solution versus placebo for treating venous leg ulcers: study protocol for a randomised controlled trial (Factorial4VLU). BMJ Open, 11 (2), e043420. http://doi.org/10.1136/bmjopen-2020-043420
Manika, D., Blokland, Y., Smith, L., Mansfield, L., & Klonizakis, M. (2021). Using stealth marketing techniques to increase physical activity and decrease sedentary time in the workplace: A feasibility study investigating the spill-overs of employee pro-environmental behaviour. International Journal of Business Science and Applied Management, 16 (1), 28-49.
Klonizakis, M., Hunt, B.E., & Woodward, A. (2020). The association between cardiovascular function, measured as FMD and CVC, and long-term aquatic exercise in older adults (ACELA study): a cross-sectional study. Frontiers in Physiology, 11, 603435. http://doi.org/10.3389/fphys.2020.603435
Lenasi, H., Drenjancevic, I., & Klonizakis, M. (2020). Editorial: Exploration of the Physiological Effects of Exercise in Cardiovascular Diseases. Frontiers in Physiology, 11, 1097. http://doi.org/10.3389/fphys.2020.01097
Mitropoulos, A., Gumber, A., Crank, H., Akil, M., & Klonizakis, M. (2020). Exploring the feasibility of an exercise programme including aerobic and resistance training in people with limited cutaneous systemic sclerosis. Clinical Rheumatology, 39 (6), 1889-1898. http://doi.org/10.1007/s10067-019-04921-7
Woodward, A., Klonizakis, M., & Broom, D. (2020). Exercise and Polycystic Ovary Syndrome. Adv Exp Med Biol, 123-136. http://doi.org/10.1007/978-981-15-1792-1_8
Woodward, A., Broom, D., Dalton, C., Metwally, M., & Klonizakis, M. (2020). Supervised exercise training and increased physical activity to reduce cardiovascular disease risk in women with polycystic ovary syndrome: Study protocol for a randomized controlled feasibility trial. Trials, 21 (1), 101. http://doi.org/10.1186/s13063-019-3962-7
Klonizakis, M., Grammatikopoulou, M.G., Theodoridis, X., Milner, M., Liu, Y., & Chourdakis, M. (2019). Effects of Long-Versus Short-Term Exposure to the Mediterranean Diet on Skin Microvascular Function and Quality of Life of Healthy Adults in Greece and the UK. Nutrients, 11 (10), e2487. http://doi.org/10.3390/nu11102487
Kesterton, S., Crank, H., Tew, G., Michaels, J., Gumber, A., McIntosh, E., ... Klonizakis, M. (2019). Participant experiences in a feasibility trial of supervised exercise training in adults with venous leg ulcers: a qualitative study. International Wound Journal. http://doi.org/10.1111/iwj.13252
Woodward, A., Broom, D., Harrop, D., Lahart, I., Carter, A., Dalton, C., ... Klonizakis, M. (2019). The effects of physical exercise on cardiometabolic outcomes in women with polycystic ovary syndrome not taking the oral contraceptive pill: a systematic review and meta-analysis. Journal of Diabetes & Metabolic Disorders, 18 (2), 597-612. http://doi.org/10.1007/s40200-019-00425-y
Mitropoulos, A., Gumber, A., Akil, M., & Klonizakis, M. (2019). Exploring the microcirculatory effects of an exercise programme including aerobic and resistance training in people with limited cutaneous systemic sclerosis. Microvascular Research, 125. http://doi.org/10.1016/j.mvr.2019.103887
Woodward, A., Klonizakis, M., Lahart, I., Carter, A., Dalton, C., Metwally, M., & Broom, D. (2019). The effects of exercise on cardiometabolic outcomes in women with polycystic ovary syndrome not taking the oral contraceptive pill: protocol for a systematic review and meta-analysis. Systematic Reviews, 8 (1). http://doi.org/10.1186/s13643-019-1030-8
Klonizakis, M. (2019). The Role of Microcirculatory Dysfunction in the Pathophysiology and Treatment of Venous Leg Ulcers. JAMA Dermatology, 155 (7), 861-862. https://jamanetwork.com/journals/jamadermatology/article-abstract/2732681
Theodoridis, X., Grammatikopoulou, M.G., Petalidou, A., Patelida, M., Gkiouras, K., Klonizakis, M., ... Bogdanos, D.P. (2019). Dietary management of celiac disease: revisiting the guidelines. Nutrition. http://doi.org/10.1016/j.nut.2019.04.008
Rogerson, D., Maçãs, D., Milner, M., Liu, Y., & Klonizakis, M. (2018). Contrasting effects of short-term mediterranean and vegan diets on microvascular function and cholesterol in younger adults: A comparative pilot study. Nutrients, 10 (12), 1897. http://doi.org/10.3390/nu10121897
Mitropoulos, A., Gumber, A., Crank, H., Akil, M., & Klonizakis, M. (2018). Investigating the effectiveness and feasibility of exercise on microvascular reactivity and quality of life in systemic sclerosis patients: study protocol for a feasibility study. Trials, 19, 647. http://doi.org/10.1186/s13063-018-2980-1
Liu, Y., Milner, M., & Klonizakis, M. (2018). Physiological effects of a short-term, lifestyle intervention based on the Mediterranean diet - comparison between older and younger healthy, sedentary adults. Nutrition, 55-56, 185-191. http://doi.org/10.1016/j.nut.2018.05.006
Klonizakis, M., Gumber, A., Mcintosh, E., King, B., Middleton, G., Michaels, J.A., & Tew, G. (2018). Exercise fidelity and progression in a supervised exercise programme for adults with venous leg ulcers. International Wound Journal, 15 (5), 822-828. http://doi.org/10.1111/iwj.12933
Klonizakis, M., Bianchi, S.M., Gernigon, M., Abraham, P., & Nawaz, S. (2018). Real-life adaptations in walking patterns in patients with established peripheral arterial disease assessed using a global positioning system in the community: A cohort study. Clinical Physiology and Functional Imaging, 38 (5), 889-894. http://doi.org/10.1111/cpf.12501
Klonizakis, M., Alkhatib, A., & Middleton, G. (2018). Commentary on: "Implementing a Mediterranean-Style Diet Outside the Mediterranean Region". Current atherosclerosis reports, 20 (9), 45. http://doi.org/10.1007/s11883-018-0744-8
Mitropoulos, A., Gumber, A., Crank, H., Akil, M., & Klonizakis, M. (2018). The effects of upper and lower limb exercise on the microvascular reactivity in limited cutaneous systemic sclerosis patients. ARTHRITIS RESEARCH & THERAPY, 20. http://doi.org/10.1186/513075-018-1605-0
Klonizakis, M., Tew, G., Gumber, A., Crank, H., King, B., Middleton, G., & Michaels, J.A. (2018). Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomised controlled feasibility trial. British Journal Of Dermatology, 178 (5), 1072-1082. http://doi.org/10.1111/bjd.16089
Rogerson, D., McNeill, S., Kononen, H., & Klonizakis, M. (2018). Encouraging effects of a short-term, adapted Nordic diet intervention on skin microvascular function and skin oxygen tension in younger and older adults. Nutrition, 49, 96-101. http://doi.org/10.1016/j.nut.2017.11.001
Klonizakis, M., Tew, G.A., Gumber, A., Crank, H., King, B., Middleton, G., & Michaels, J.A. (2018). Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomized controlled feasibility trial. British Journal of Dermatology, 178 (5), e361. http://doi.org/10.1111/bjd.16618
Tew, G.A., Gumber, A., Mcintosh, E., Kesterton, S., King, B., Michaels, J.A., & Klonizakis, M. (2017). Effects of supervised exercise training on lower-limb cutaneous microvascular reactivity in adults with venous ulcers. European Journal of Applied Physiology, 118 (2), 321-329. http://doi.org/10.1007/s00421-017-3772-0
Mitropoulos, A., Gumber, A., Crank, H., & Klonizakis, M. (2017). Validation of an arm crank ergometer test for use in sedentary adults. Journal of Sports Science and Medicine, 16, 558-564. http://www.jssm.org/abstresearchajssm-16-558.xml.xml
Oggioni, C., Jakovljevic, D.G., Klonizakis, M., Ashor, A.W., Ruddock, A., Ranchordas, M., ... Siervo, M. (2017). Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults : a randomised cross over study. International Journal of Food Sciences and Nutrition, 69 (1), 74-83. http://doi.org/10.1080/09637486.2017.1328666
Klonizakis, M., Crank, H., Gumber, A., & Brose, L.S. (2017). Smokers making a quit attempt using e-cigarettes with or without nicotine or prescription nicotine replacement therapy : impact on cardiovascular function (ISME-NRT) - a study protocol. BMC public health, 17 (1). http://doi.org/10.1186/s12889-017-4206-y
Hodges, G.J., Mallette, M.M., Tew, G.A., Saxton, J.M., Moss, J., Ruddock, A.D., & Klonizakis, M. (2017). Effect of age on cutaneous vasomotor responses during local skin heating. Microvascular Research, 112, 47-52. http://doi.org/10.1016/j.mvr.2017.03.002
Lenasi, H., & Klonizakis, M. (2017). Assessing the evidence: exploring the effects of exercise on diabetic microcirculation. Clinical Hemorheology and Microcirculation, 64 (4), 663-678. http://doi.org/10.3233/CH-168022
Siervo, M., Oggioni, C., Gjakovljevic, D.G., Trenell, M., Mathers, J.C., Houghton, D., ... Williams, E.A. (2016). Dietary nitrate does not have an effect on physical activity outcomes in healthy older adults : a randomized, cross-over trial. Nutrition Research, 36 (12), 1361-1369. http://doi.org/10.1016/j.nutres.2016.11.004
Wasilewski, R., Ubara, E.O., & Klonizakis, M. (2016). Assessing the effects of a short-term green tea intervention in skin microvascular and oxygen tension in older and younger adults. Microvascular Research, 107, 65-71. http://doi.org/10.1016/j.mvr.2016.05.001
Tew, G.A., Michaels, J., Crank, H., Middleton, G., Gumber, A., & Klonizakis, M. (2015). Supervised exercise training as an adjunctive therapy for venous leg ulcers: study protocol for a randomised controlled trial. Trials, 16 (1). http://doi.org/10.1186/s13063-015-0963-z
Humeau-Heurtier, A., & Klonizakis, M. (2015). Processing of laser Doppler Flowmetry signals from healthy subjects and patients with varicose veins : information categorization approach based on intrinsic mode functions and entropy computation. Medical Engineering and Physics, 37 (6), 553-559. http://doi.org/10.1016/j.medengphy.2015.03.020
Middleton, G., Keegan, R., Alkhatib, A., Smith, M., & Klonizakis, M. (2015). Implementing a Mediterranean diet intervention into a RCT : lessons learned from a non-Mediterranean based country, today. Journal of Nutrition, Health and Aging, 19 (7), 771-777. http://doi.org/10.1007/s12603-015-0663-0
Cogate, P.G., Natali, A.J., de Oliveira, A., Alfenas, R.C., & Hermsdorff, H.H.M. (2015). Consumption of Branched-Chain Amino Acids Is Inversely Associated with Central Obesity and Cardiometabolic Features in a Population of Brazilian Middle-Aged Men: Potential Role of Leucine Intake. The journal of nutrition, health & aging, 19 (7), 771-777. http://doi.org/10.1007/s12603-015-0521-0
Klonizakis, M., Alkhatib, A., & Middleton, G. (2014). Long-term effects of an exercise and Mediterranean diet intervention in the vascular function of an older, healthy population. Microvascular Research, 95, 103-107. http://doi.org/10.1016/j.mvr.2014.07.015
Alkhatib, A., & Klonizakis, M. (2014). Effects of exercise training andMediterranean diet on vascular risk reductionin post-menopausal women. Clinical Hemorheology and Microcirculation, 57 (1), 33-47. http://doi.org/10.3233/CH-131770
Klonizakis, M., Moss, J., Gilbert, S., Broom, D., Foster, J., & Tew, G.A. (2014). Low-volume high-intensity interval training rapidly improvescardiopulmonary function in postmenopausal women. Menopause, 21 (10), 1099-1105. http://doi.org/10.1097/gme.0000000000000208
Klonizakis, M., Manning, G., Lingam, K., Donnelly, R., & Yeung, J.M.C. (2014). Effect of diabetes on the cutaneous microcirculation of the feet in patients with intermittent claudication. Clinical Hemorheology and Microcirculation, 61 (3), 439-444. http://doi.org/10.3233/CH-141907
Klonizakis, M., & Humeau-Heurtier, A. (2013). Multifractal analysis of laser Doppler flowmetry signals before and after arm-cranking exercise in an older healthy population. Journal of Medical Physics, 40 (2). http://doi.org/10.1118/1.4774362
Klonizakis, M., Alkhatib, A., Middleton, G., & Smith, M.F. (2013). Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity. Clinical Science, 124 (9), 579-587. http://doi.org/10.1042/CS20120412
Khan, A.A., Klonizakis, M., Shabaan, A., & Glynne-Jones, R. (2013). Association between pretreatment haemoglobin levels and morphometric characteristics of the tumour, response to neoadjuvant treatment and long-term outcomes in patients with locally advanced rectal cancers. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 15 (10), 1232-1237. http://doi.org/10.1111/codi.12307
Klonizakis, M. (2012). Studying the cutaneous microcirculatory response during upper-limb exercise in healthy, older, sedentary people. Clinical Hemorheology and Microcirculation, 51 (1), 69-75. http://doi.org/10.3233/CH-2011-1510
Huedo-Medina, T.B., Kirsch, I., Middlemass, J., Klonizakis, M., & Siriwardena, A.N. (2012). Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration. British Medical Journal (BMJ), 17 (345). http://doi.org/10.1136/bmj.e8343
Klonizakis, M., Manning, G., & Donnelly, R. (2011). Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser Doppler techniques. Skin Pharmacology and Physiology, 24 (3), 136-143. http://doi.org/10.1159/000322853
Klonizakis, M., Lingam, K., Manning, G., & Donnelly, R. (2011). Characterising the time-course of microvascular vasodilator responses in humans using Laser Doppler Fluximetry and iontophoresis. Journal of Pharmacological and Toxicological Methods, 63 (1), 115-118. http://doi.org/10.1016/j.vascn.2010.07.001
Tew, G., Klonizakis, M., Crank, H., Briers, J.D., & Hodges, G.J. (2011). Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvascular Research, 82 (3), 326-332. http://doi.org/10.1016/j.mvr.2011.07.007
Yeung, J.M.C., Klonizakis, M., Lingam, K., Manning, G., & Donnelly, R. (2011). Effects of Lower Limb Angioplasty on Endothelial-Dependent and -Independent Microvascular Reactivity. European Journal of Vascular and Endovascular Surgery, 42 (6), 856. http://doi.org/10.1016/j.ejvs.2011.09.001
Yeung, J.M.C., Klonizakis, M., Lingam, K., Manning, G., & Donnelly, R. (2011). Effects of Lower Limb Angioplasty on Endothelial-Dependent and -Independent Microvascular Reactivity. EJVES Extra, 22 (5), e52-e54. http://doi.org/10.1016/j.ejvsextra.2011.08.001
Klonizakis, M., & Winter, E. (2011). Effects of arm-cranking exercise in cutaneous microcirculation in older, sedentary people. Microvascular Research, 81 (3), 331-336. http://doi.org/10.1016/j.mvr.2011.01.008
Tew, G.A., Saxton, J.M., Klonizakis, M., Moss, J., Ruddock, A.D., & Hodges, G.J. (2011). Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. Journal of applied physiology (Bethesda, Md. : 1985), 110 (5), 1264-1270. http://doi.org/10.1152/japplphysiol.01423.2010
Tew, G., Klonizakis, M., Moss, J., Ruddock, A., Saxton, J., & Hodges, G.J. (2011). Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. Experimental Physiology, 96 (2), 163-170. http://doi.org/10.1113/expphysiol.2010.055434
Tew, G., Klonizakis, M., & Saxton, J. (2010). Effects of ageing and fitness on skin-microvessel vasodilator function in humans. European journal of applied physiology, 109 (2), 173-181. http://doi.org/10.1007/s00421-009-1342-9
Klonizakis, M., Tew, G., Michaels, J.A., & Saxton, J. (2010). Effects of upper-limb exercise on lower-limb cutaneous microvascular function in post-surgical varicose-vein patients. European journal of applied physiology, 109 (6), 1221-1224. http://doi.org/10.1007/s00421-010-1471-1
Tew, G., Klonizakis, M., Moss, J., Ruddock, A., Saxton, J., & Hodges, G.J. (2010). Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvascular Research, 81 (2), 177-182. http://doi.org/10.1016/j.mvr.2010.12.001
Kerr, S.F., Klonizakis, M., & Glynne-Jones, R. (2010). Suppression of the postoperative neutrophil leucocytosis following neoadjuvant chemoradiotherapy for rectal cancer and implications for surgical morbidity. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 12 (6), 549-554. http://doi.org/10.1111/j.1463-1318.2009.01858.x
Klonizakis, M., Tew, G., Michaels, J., & Saxton, J. (2009). Exercise training improves cutaneous microvascular endothelial function in post-surgical varicose vein patients. Microvascular research, 78 (1), 67-70. http://doi.org/10.1016/j.mvr.2009.03.002
Klonizakis, M., Tew, G., Michaels, J., & Saxton, J.M. (2009). Impaired microvascular endothelial function is restored by acute lower-limb exercise in post-surgical varicose vein patients. Microvascular research, 77 (2), 158-162. http://doi.org/10.1016/j.mvr.2008.09.009
Klonizakis, M., Yeung, J.M.-.C., Lingam, K., Nash, J.R., Manning, G., & Donnelly, R. (2006). Contrasting effects of varicose vein surgery on endothelial-dependent and -independent cutaneous vasodilation in the perimalleolar region. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 31 (4), 434-438. http://doi.org/10.1016/j.ejvs.2005.10.017
Klonizakis, M. (2006). The Use of Magnetic Resonance Imaging in Cardiovascular Studies: A Case Study for Mitral Regurgitation. WSEAS Trans Maths Comp in Biol and Med, 3 (2), 311-316.
Klonizakis, M., Yeung, J.M.C., Nash, J.R., Lingam, K., Manning, G., & Donnelly, R. (2003). Effects of posture and venous insufficiency on endothelial-dependent and -independent cutaneous vasodilation in the perimalleolar region. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 26 (1), 100-104. http://doi.org/10.1053/ejvs.2002.1953
Yeung, J.M.C., Klonizakis, M., Nash, J.R., Lingam, M.K., Manning, G., & Donnelly, R. (2002). Upright Posture Impairs Microvascular Vasodilation in Patients with Varicose Veins – Possible Role in Ulcer Formation. Clinical Science, 103 (s47), 7P-8P. http://doi.org/10.1042/cs103007pb
Cocate, P.G., Natali, A.J., de Oliveira, A., Alfenas, R.C., & Hermsdorff, H.H.M. (n.d.). Consumption of branched-chain amino acids is inversely associated with central obesity and cardiometabolic features in a population of Brazilian middle-aged men: Potential role of leucine intake. The journal of nutrition, health & aging. http://doi.org/10.1007/s12603-015-0522-z
Conference papers
Parkington, T., Broom, D., Maden-Wilkinson, T., Nawaz, S., Shahzad, N., & Klonizakis, M. (2024). A novel exercise approach to improve exercise performance and quality of life in intermittent claudicants [abstract only]. European Journal of Vascular and Endovascular Surgery, 67 (3), e48-e49. http://doi.org/10.1016/j.ejvs.2024.01.042
Klonizakis, M., McIntosh, E., Gumber, A., & Brose, L. (2022). Exploring the medium- and longer-term macrovascular effects of e-cigarettes and Nicotine Replacement Therapy in adults making a stop-smoking attempt. ACTA PHYSIOLOGICA, 236, 857.
Klonizakis, M. (2021). Pathophysiology and treatment options for venous ulceration: Is there a role for exercise? BIORHEOLOGY, 58 (3-4), 102-103.
Klonizakis, M., Rogerson, D., Milner, M., Kononen, H., McNeill, S., & Liu, Y. (2019). Exploring the short-term, physiological, micro-circulatory effects of regional diets in sedentary, older, adult populations [Abstract only]. Acta Physiologica, 227 (S718), 13. http://doi.org/10.1111/apha.13366
Klonizakis, M. (2018). Using exercise as an adjunct therapy in microcirculatory diseases – reporting the evidence on venous ulceration and systemic sclerosis. Vascular Investigation and Therapy.
Mitropoulos, A., Gumber, A., Crank, H., Akil, M., & Klonizakis, M. (2018). The effects of upper and lower limb exercise on the microvascular reactivity in systemic sclerosis patients (abstract only). Annals of the Rheumatic Diseases, 77, 1788. http://doi.org/10.1136/annrheumdis-2018-eular.1979
Middleton, G., Keegan, R., Smith, M., Alkhatib, A., & Klonizakis, M. (2015). Exploring barriers and facilitators to eating the Mediterranean diet in England : a qualitative study. Proceedings of the Nutrition Society, 74 (OCE1). http://doi.org/10.1017/S0029665115001585
Klonizakis, M. (2015). INFLUENCE OF G6PD ON VASCULAR PHENOTYPE IN OBESE, OBESE-DIABETICS AND T2D. JOURNAL OF VASCULAR RESEARCH, 52, 21.
Hussain, F.H., Klonizakis, M., Ayube, J., Zaman, Q., & Khan, A. (2015). The Current Era Of Merging NHS Trusts - Impact on Patient Experience and Satisfaction to Re-Organised Surgical Services. BRITISH JOURNAL OF SURGERY, 102, 250-251.
Alkhatib, A., & Klonizakis, M. (2013). Reduction in post-menopausal related vascular dysfunction through exercise and Mediterranean diet. Proceedings of the Nutrition Society, 72 (OCE4). http://doi.org/10.1017/s0029665113003273
Klonizakis, M. (2011). Effect of ageing and fitness on skin-micro-vessel vasodilator function in humans. JOURNAL OF VASCULAR RESEARCH, 48, 36.
Amrou, S., Khan, A., Klonizakis, M., Anyamene, N., Mawdsley, S., Denton, A., ... Glynnes-Jones, R. (2010). THE IMPACT OF PRE-TREATMENT HAEMOGLOBIN AND TUMOUR LENGTH ON DISEASE FREE SURVIVAL AND LOCAL RECURRENCE IN RECTAL CANCERS TREATED WITH PRE-OPERATIVE CHEMO-RADIOTHERAPY. ANNALS OF ONCOLOGY, 21, 59-60.
Sharma, S., Moffat, D., Christopoulous, C., Klonizakis, M., Wellstead, D., Farrington, K., & Gorog, D.A. (2010). Global thrombotic status predicts cardiovascular events in end-stage renal failure. EUROPEAN HEART JOURNAL, 31, 971.
Books
Klonizakis, M., Lenasi, H., & Drenjančević, I. (Eds.). (2020). Exploration of the Physiological Effects of Exercise in Cardiovascular Diseases. Frontiers.
Klonizakis, M., Lenasi, H., & Drenjančević, I. (Eds.). (2020). Exploration of the Physiological Effects of Exercise in Cardiovascular Diseases. Frontiers.
Klonizakis, M. (2010). Cutaneous Microcirculation and Lower-Limb Venous Disease. (1st). Saarbrücken, Germany: Lambert Academic Publishing.
Theses / Dissertations
Parkington, T. (2022). Feasibility of Blood Flow Restriction Resistance Exercise for Patients with Intermittent Claudication. (Doctoral thesis). Supervised by Klonizakis, M., Broom, D., & Maden-Wilkinson, T. http://doi.org/10.7190/shu-thesis-00509
Woodward, A. (2021). Physical activity and cardiovascular disease risk in women with polycystic ovary syndrome. (Doctoral thesis). Supervised by Klonizakis, M., Broom, D., Piercy, H., & Metwally, M. http://doi.org/10.7190/shu-thesis-00398
Mitropoulos, A. (2018). The Effects of Exercise on Vascular Physiologyin Systemic Sclerosis Patients. (Doctoral thesis). Supervised by Klonizakis, M. http://doi.org/10.7190/shu-thesis-00213
Internet Publications
Klonizakis, M. (2021). Can swimming help prevent cardiovascular disease? [Newspaper Article]. https://www.independent.co.uk/health_and_wellbeing/swimming-water-exercise-pool-cardiovascular-disease-b1776190.html
Wardill, J. (2020). "15 weeks of hell": A story of a Long-haul COVID-19 sufferer. [Newspaper Article].
Benz, M. (2020). Brief Mediterranean diet intervention may have long term benefits. [Journal article]. https://medicalresearch.com/author-interviews/brief_mediterranean_diet_intervention_may_have_long_term_benefits/8924/
Vasilopoulos, C. (2020). 40 Years of the Mediterranean Diet: What's Next for the World's Healthiest Eating Plan. [Journal article]. https://www.oliveoiltimes.com/health-news/40-years-of-the-mediterranean-diet-whats-next-for-the-worlds-healthiest-eating-plan/81317
Klonizakis, M. (2020). Working out in the age of the coronavirus. [Journal article]. https://www.zmescience.com/science/news-science/working-out-in-the-age-of-the-coronavirus/
Klonizakis, M. (2020). Water exercises as effective as gym workouts for preventing cardiovascular disease – new research. https://theconversation.com/water-exercises-as-effective-as-gym-workouts-for-preventing-cardiovascular-disease-new-research-151522
Cox, D. (2019). Is veganism as good for you as they say? [Newspaper article]. https://www.theguardian.com/lifeandstyle/2019/dec/29/is-veganism-as-good-for-you-as-they-say
Klonizakis, M. (2019). Smokers who switch to vaping could be less likely to use cigarettes again, says study. [Newspaper Article]. https://www.independent.co.uk/news/health/vaping-ecigarettes-stop-smoking-less-harmful-study-a8710986.html
Klonizakis, M. (2019). Mediterranean diets reduce risk of heart disease – new research shows. https://www.independent.co.uk/life-style/health-and-families/healthy-living/mediterranean-diet-vegan-heart-health-food-choice-a8769281.html
Klonizakis, M. (2019). Vegan or Mediterranean diet – which is better for heart health? [Journal Article]. https://theconversation.com/vegan-or-mediterranean-diet-which-is-better-for-heart-health-110052
Klonizakis, M. (2019). Vaping: smokers who switch could be less likely to use cigarettes again. [Journal article]. https://theconversation.com/vaping-smokers-who-switch-could-be-less-likely-to-use-cigarettes-again-109098
Larbi, M. (2019). How to lose weight fast – 5:2 diet doctor tips from curry cheat meals to snacking on eggs. [Journal article]. https://www.thesun.co.uk/fabulous/9242061/tv-doc-weight-loss-curry-egg/
Dawes, L. (2017). Serena Williams: How can you win a Grand Slam while pregnant? [Journal article]. https://www.bbc.co.uk/sport/tennis/39653317
McLennan, M. (2017). Shun the screens to get some quality shut-eye, boffin urges. https://www.thestar.co.uk/news/shun-screens-get-some-quality-shut-eye-boffin-urges-449794
Media
Mullin, G. (2020). How to lose weight fast with the best diets of 2020 – including keto, vegan and Mediterranean. [Newspaper]. The Sun: https://www.thesun.co.uk/fabulous/10655638/lose-weight-fast-8-best-diets-2020-keto-vegan-mediterranean/
Presentations
Mitropoulos, A., Gumber, A., Crank, H., & Klonizakis, M. (2017). The effects of upper and lower limb exercise on the microvascular reactivity in systemic sclerosis patients. Presented at: Physiological Society Conference, Leeds
Klonizakis, M., Tew, G.A., & Gumber, A. (2015). Exploring the feasibility of implementing an exercise intervention in patients with venous ulceration under a national healthcare system – a study protocol. Presented at: 10th World Congress for Microcirculation, Kyoto
Datasets
Klonizakis, M. (n.d.). Exploring the Feasibility of Implementing a Supervised Exercise Training and Compression Hosiery Intervention in Patients with Venous Ulceration (FISCU).. http://doi.org/10.1186/isrctn10205425
Klonizakis, M., & McIntosh, E. (n.d.). Development and feasibility-testing of a home-based exercise training and compression hosiery intervention for people with venous ulceration.. http://doi.org/10.1186/isrctn16899826
Other activities
Among others, I am a member of the editorial board for the following journals:
- i) Journal of Pharmacological and Toxicological Methods (2011-) (Elsevier Science)
- ii) Clinical Hemorheology and Microcirculation (2014-) (IOS Publishing)
- iii) Nutrients (Guest Editor) (2018-) (MDPI)
- iv) Frontiers in Physiology (Guest Editor) (2018-) (Frontiers)
I am also a member of the Publications Committee of the Physiological Society.
Postgraduate supervision
Recently completed PhD/MD supervisions include:
- 1)Miss Amie Woodward (Accepted with minor amendments). (as Director of Studies).
Title: Physical activity and cardiovascular disease risk in women with polycystic ovary syndrome.
(Sheffield Hallam University, Sheffield Teaching Hospitals NHS Foundation Trust).
Funded by the Vice Chancellor Scholarship at Sheffield Hallam University. - 2)Dr Alexandros Mitropoulos (PhD). (as Director of Studies).
Title: Investigating the effectiveness and feasibility of exercise on microcirculatory parameters and quality of life in systemic sclerosis patients.
(Sheffield Hallam University, Sheffield Teaching Hospitals NHS Foundation Trust).
Funded by the Vice Chancellor Scholarship at Sheffield Hallam University. - 3)Dr Sumeet Sharma (MD) (as Second Supervisor).
Title: Thrombotic Risk Assessment in End Stage Renal Disease Patients on Renal Replacement Therapy.
University of Hertfordshire. - 4)Dr Smriti Saraf (MD) (As Academic Supervisor).
Title: Assessment of Thrombotic and Thrombolytic Status in Patients with Coronary Artery Disease and its Relation to Clinical Outcomes.
University of Hertfordshire.
Media
Markos has provided expert opinions on the effects of pregnancy on exercise performance (BBC Sport, "The Washington Post" newspaper), on nutrition ("The Sun" newspaper) as well as on the physiological effects of smoking cessation ("Sheffield Star" newspaper, BBC Radio, Hallam FM). His articles on "The Conversation" have been reprinted in many national and international media, while he has written articles published in "The Independent" newspaper.
Recent work by Markos and his colleagues on the effects of the Mediterranean Diet in the vascular function of older, sedentary people has been featured in regional (Yorkshire and Lincolnshire), national and international (Greece, USA and Australia) media, with interviews being given to the "Fitness" magazine, medical research websites and blogs, and the BBC regional radio stations.