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Professor Emerita Nicola Woodroofe BSc, PhD, SFHEA

Professor Emerita


Summary

I was appointed as a senior lecturer at Sheffield Hallam University in 1994, after completing my BSc and PhD in Biochemistry at the University of London and 15 years as a postdoctroal researcher. I was promoted to Professor in 2005 based on my international profile in the field of neuroimmunology and specifically multiple sclerosis. I retired in 2020 and I am now an emeritus professor.

About

After appointment as a senior lecturer , I taught cell biology, immunology, pathological sciences and neuroscience at undergraduate and masters levels. I have supervised over 25 research students to complete their doctoral degrees. I have collaborated with consultant neurologists at Sheffield Teaching Hospitals NHS Foundation Trust for many years specifically in research on multiple sclerosis and gluten ataxia. I have published around 100 papers adn abstracts and presented my research work at international conferences.

I continue to act as a referee for a number of journals and grant awarding bodies.

Specialist areas of interest

Neuroimmunology, autoimmunity, metalloproteinases, cytokines and chemokines

Teaching

Department of Biosciences and Chemistry

Health And Wellbeing

Research

Investigations of the pathogens of multiple sclerosis

Publications

Journal articles

Rawlinson, K.E., Duckett, C., Shaw, H., Woodroofe, M.N., & Lacey, M. (2021). Family-focused campus-based university event increases perceived knowledge, science capital and aspirations across a wide demographic. International Journal of Science Education, Part B: Communication and Public Engagement. http://doi.org/10.1080/21548455.2021.1971319

Pousinis, P., Ramos, I.R., Woodroofe, M.N., & Cole, L.M. (2020). Lipidomic UPLC-MS/MS Profiles of Normal-Appearing White Matter Differentiate Primary and Secondary Progressive Multiple Sclerosis. Metabolites, 10 (9), e366. http://doi.org/10.3390/metabo10090366

Aldewachi, H., Chalati, T., Woodroofe, N., Bricklebank, N., Sharack, B., & Gardiner, P. (2018). Gold nanoparticle-based colorimetric biosensors. Nanoscale, 10 (1), 18-33. http://doi.org/10.1039/c7nr06367a

Salman, M., Kitchen, P., Woodroofe, N., Bill, R.M., Conner, A.C., Heath, P.R., & Conner, M.T. (2017). Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia. Frontiers in cellular neuroscience, 11, 386. http://doi.org/10.3389/fncel.2017.00386

Ramos, I., Lyng, F.M., Rehman, I.U., Sharrack, B., & Woodroofe, N. (2017). The use of vibrational spectroscopy to study the pathogenesis multiple sclerosis and other neurological conditions. Applied Spectroscopy Reviews, 52. http://www.tandfonline.com/doi/abs/10.1080/05704928.2017.1336450

Salman, M., Kitchen, P., Woodroofe, N., Brown, J.E., Bill, R.M., Conner, A.C., & Conner, M.T. (2017). Hypothermia increases aquaporin 4 (AQP4) plasma membrane abundance in human primary cortical astrocytes via a calcium/ transient receptor potential vanilloid 4 (TRPV4)- and calmodulin-mediated mechanism. European Journal of Neuroscience, 46 (9), 2542-2547. http://doi.org/10.1111/ejn.13723

Salman, M., Sheilabi, M.A., Bhattacharyya, D., Kitchen, P., Conner, A.C., Bill, R.M., ... Princivalle, A. (2017). Transcriptome analysis suggests a role for the differential expression of cerebral aquaporins and the MAPK signalling pathway in human temporal lobe epilepsy. The European Journal of Neuroscience, 46 (5), 2121-2132. http://doi.org/10.1111/ejn.13652

Aldewachi, H., Woodroofe, N., Turega, S., & Gardiner, P. (2017). Optimization of gold nanoparticle-based real-time colorimetric assay of dipeptidyl peptidase IV activity. Talanta, 169, 13-19. http://doi.org/10.1016/j.talanta.2017.03.039

Crank, H., Carter, A., Humphreys, L., Snowdon, N., Daley, A., Woodroofe, N., ... Saxton, J.M. (2017). A qualitative investigation of exercise perceptions and experiences in people with multiple sclerosis before, during and after participation in a personally-tailored exercise program. Archives of Physical Medicine and Rehabilitation, 98 (12), 2520-2525. http://doi.org/10.1016/j.apmr.2017.05.022

Waller, R., Woodroofe, N., Wharton, S.B., Ince, P.G., Francese, S., Heath, P.R., ... Simpson, J.E. (2016). Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role. Journal of Neuroimmunology, 299, 139-146. http://doi.org/10.1016/j.jneuroim.2016.09.010

Shanmugarajah, P.D., Hoggard, N., Currie, S., Aeschlimann, D.P., Aeschlimann, P.C., Gleeson, D.C., ... Hadjivassiliou, M. (2016). Alcohol-related cerebellar degeneration: not all down to toxicity? Cerebellum & Ataxias. http://doi.org/10.1186/s40673-016-0055-1

Carter, A., Humphreys, L., Snowdon, N., Sharrack, B., Daley, A., Petty, J., ... Saxton, J. (2015). Participant recruitment into a randomised controlled trial of exercise therapy for people with multiple sclerosis. Trials, 16 (1). http://doi.org/10.1186/s13063-015-0996-3

Amor, S., & Woodroofe, N. (2014). Innate and adaptive immune responses in neurodegeneration and repair. Immunology, 141 (3), 287-291. http://doi.org/10.1111/imm.12134

Carter, A., Daley, A., Humphreys, L., Snowdon, N., Woodroofe, N., Petty, J., ... Saxton, J. (2014). Pragmatic intervention for increasing self-directed exercise behaviour and improving important health outcomes in people with multiple sclerosis : a randomised controlled trial. Multiple Sclerosis, 20 (8), 1112-1122. http://doi.org/10.1177/1352458513519354

Saxton, J., Scott, E.J., Daley, A.J., Woodroofe, N., Mutrie, N., Crank, H., ... Coleman, R.E. (2014). Effects of an exercise and hypocaloric healthy eating intervention on indices of psychological health status, hypothalamic-pituitary-adrenal axis regulation and immune function after early-stage breast cancer : a randomised controlled trial. Breast Cancer Research, 16 (2), R39. http://doi.org/10.1186/bcr3643.

Battle, R., Turner, D., Woodroofe, N., & Clark, B. (2014). Identified HLA class I epitopes can undergo conformational induced variation due to changes within HLA bound peptides. Immunology Letters, 161 (1), 57-58. http://doi.org/10.1016/j.imlet.2014.04.016

Bradford, C.M., Ramos, I., Cross, A.K., Haddock, G., McQuaid, S., Nicholas, A.P., & Woodroofe, M.N. (2014). Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis. Journal of Neuroimmunology, 273 (1-2), 85-95. http://doi.org/10.1016/j.jneuroim.2014.05.007

Saxton, J.M., Scott, E., Daley, A.J., Woodroofe, M.N., Mutrie, N., Crank, H., ... Coleman, R.E. (2014). Effects of an exercise and hypocaloric healthy eating intervention on indices of psychological health status, hypothalamic-pituitary-adrenal axis regulation and immune function after early-stage breast cancer: a randomised controlled trial. Breast Cancer Research, 16 (2), R39. http://doi.org/10.1186/bcr3643

Carter, A.M., Daley, A.J., Kesterton, S.W., Woodroofe, N., Saxton, J.M., & Sharrack, B. (2013). Pragmatic exercise intervention in people with mild to moderate multiple sclerosis: A randomised controlled feasibility study. Contemporary Clinical Trials, 35 (2), 40-47. http://doi.org/10.1016/j.cct.2013.04.003

Kelly, D.M., Sellers, D.J., Woodroofe, M.N., Jones, T.H., & Channer, K.S. (2013). Effect of testosterone on inflammatory markers in the development of early atherogenesis in the testicular-feminized mouse model. Endocrine Research, 38 (3), 125-138. http://doi.org/10.3109/07435800.2012.735307

Hart, P.J., Francese, S., Woodroofe, M.N., & Clench, M.R. (2013). Matrix assisted laser desorption ionisation ion mobility separation mass spectrometry imaging of ex-vivo human skin. International Journal for Ion Mobility Spectrometry, 16 (2), 71-83. http://doi.org/10.1007/s12127-013-0124-6

Battle, R., Woodroofe, N., Clench, M., & Clark, B. (2013). The relationship of HLA-class I derived leader peptide mismatch and renal function within the first 12months post-renal transplant. Tissue Antigens, 82 (4), 291-292. http://doi.org/10.1111/tan.12191

Hadjivassiliou, M., Aeschlimann, P., Sanders, D.S., Mäki, M., Kaukinen, K., Grünewald, R.A., ... Aeschlimann, D.P. (2013). Transglutaminase 6 antibodies in the diagnosis of gluten ataxia. Neurology, 80 (19), 1740-1745. http://doi.org/10.1212/WNL.0b013e3182919070

Saxton, J., Carter, A., Daley, A.J., Snowdon, N., Woodroofe, N., Petty, J., ... Sharrack, B. (2013). Pragmatic exercise intervention for people with multiple sclerosis (ExIMS Trial) : study protocol for a randomised controlled trial. Contemporary Clinical Trials, 34 (2), 205-211. http://doi.org/10.1016/j.cct.2012.10.011

Scott, E., Daley, A.J., Doll, H., Woodroofe, N., Mutrie, N., Crank, H., ... Saxton, J. (2013). Effects of an exercise and hyocaloric healthy eating program on biomarkers asociated with long term prognosis after early stage breast cancer:a randomized controlled trial. Cancer Causes and Control, 24 (1), 181-191. http://doi.org/10.1007/s10552-012-0104-x

Stout, M., Tew, G.A., Doll, H., Zwierska, I., Woodroofe, N., Channer, K.S., & Saxton, J.M. (2012). Testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: A double-blind randomized controlled feasibility study. American Heart Journal, 164 (6), 893-901. http://doi.org/10.1016/j.ahj.2012.09.016

Battle, R., Poole, K., Haywood-Small, S., Clark, B., & Woodroofe, N. (2012). Molecular characterisation of the monocytic cell line THP-1 demonstrates a discrepancy with the documented HLA type. International Journal of Cancer, 132 (1), 246-247. http://doi.org/10.1002/ijc.27661

Hurst, L.A., Bunning, R.A.D., Sharrack, B., & Woodroofe, M.N. (2012). siRNA knockdown of ADAM-10, but not ADAM-17, significantly reduces fractalkine shedding following pro-inflammatory cytokine treatment in a human adult brain endothelial cell line. Neuroscience Letters, 521 (1), 52-56. http://doi.org/10.1016/j.neulet.2012.05.057

Fouillet, A., Mawson, J., Suliman, O., Sharrack, B., Romero, I.A., & Woodroofe, N.W. (2012). CCL2 binding is CCR2 independent in primary adult human astrocytes. Brain Research, 1437, 115-126. http://doi.org/10.1016/j.brainres.2011.11.049

Frentzou, G., Bradford, C., Harkness, K.A., Haddock, G., Woodroofe, N.W., & Cross, A. (2012). IL-1β Down-Regulates ADAMTS-13 mRNA Expression in Cells of the Central Nervous System. Journal of Molecular Neuroscience, 46 (2), 343-351. http://doi.org/10.1007/s12031-011-9591-6

Waller, R., Woodroofe, M.N., Francese, S., Heath, P.R., Wharton, S.B., Ince, P.G., ... Simpson, J.E. (2012). Isolation of enriched glial populations from post-mortem human CNS material by immuno-laser capture microdissection. Journal of Neuroscience Methods, 208 (2), 108-113. http://doi.org/10.1016/j.jneumeth.2012.04.014

Hart, P.J., Francese, S., Claude, E., Woodroofe, M.N., & Clench, M.R. (2011). MALDI-MS imaging of lipids in ex vivo human skin. Analytical and Bioanalytical Chemistry, 401 (1), 115-125. http://doi.org/10.1007/s00216-011-5090-4

Hadjivassiliou, M., Aeschlimann, D., Gruenewald, R.A., Sanders, D.S., Sharrack, B., & Woodroofe, N.W. (2011). GAD antibody-associated neurological illness and its relationship to gluten sensitivity. Acta Neurologica Scandinavica, 123 (3), 175-180. http://doi.org/10.1111/j.1600-0404.2010.01356.x

Bradford, C.M., Cross, A., Haddock, G., Woodroofe, N.W., & Sharrack, B. (2011). Citrullination of CNS proteins in the pathogenesis of multiple sclerosis. Future Neurology, 6 (4), 521-530. http://doi.org/10.2217/fnl.11.30

Dhungana, S., Waters, P., Ismail, A., Woodroofe, N., Vincent, A., & Sharrack, B. (2010). Absence of aquaporin-4 antibodies in patients with idiopathic intracranial hypertension. Journal of Neurology, 257 (7), 1211-1212. http://doi.org/10.1007/s00415-010-5499-2

Dhungana, S., Sharrack, B., & Woodroofe, N. (2010). Idiopathic intracranial hypertension. Acta neurologica Scandinavica, 121 (2), 71-82. http://doi.org/10.1111/j.1600-0404.2009.01172.x

Hadjivassiliou, M., Sanders, D.S., Grunewald, R.A., Woodroofe, N., Boscolo, S., & Aeschlimann, D. (2010). Gluten sensitivity: from gut to brain. The Lancet Neurology, 9 (3), 318-330. http://doi.org/10.1016/S1474-4422(09)70290-X

Dhungana, S., Waters, P., Ismail, A., Woodroofe, N., Vincent, A., & Sharrack, B. (2010). Erratum: Absence of aquaporin-4 antibodies in patients with idiopathic intracranial hypertension (Journal of Neurology (2010) 257 DOI: 10.1007/s00415-010-5499-2). Journal of Neurology, 257 (7), 1229-1230. http://doi.org/10.1007/s00415-010-5553-0

Dhungana, S., Sharrack, B., & Woodroofe, N. (2009). Cytokines and chemokines in idiopathic intracranial hypertension. Headache: the journal of head and face pain, 49 (2), 282-285. http://doi.org/10.1111/j.1526-4610.2008.001329.x

Taylor, D., Dalton, C., Hall, A., Woodroofe, M.N., & Gardiner, P. (2009). Recent developments in selenium research. British journal of biomedical science, 66 (2), 107-116. http://doi.org/10.1080/09674845.2009.11730256

Denney, H., Clench, M., & Woodroofe, M.N. (2009). Cleavage of chemokines CCL2 and CXCL10 by matrix metalloproteinases-2 and -9: implications for chemotaxis. Biochemical and biophysical research communications, 382 (2), 341-347. http://doi.org/10.1016/j.bbrc.2009.02.164

Hurst, L.A., Bunning, R.A.D., Couraud, P.-.O., Romero, I.A., Weksler, B.B., Sharrack, B., & Woodroofe, M.N. (2009). Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment. Journal of neuroimmunology, 210 (1-2), 108-112. http://doi.org/10.1016/j.jneuroim.2009.02.008

Reid, M.J., Cross, A.K., Haddock, G., Allan, S.M., Stock, C.J., Woodroofe, M.N., ... Bunning, R.A.D. (2009). ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat. Neuroscience letters, 452 (3), 252-257. http://doi.org/10.1016/j.neulet.2009.01.058

Bradford, C.M., Cross, A.K., Haddock, G., & Woodroofe, M.N. (2009). Citrullination in MS: potential for a new diagnostic test. British journal of neuroscience nursing, 5 (1), 1-13. http://www.bjnn.co.uk/cgi-bin/go.pl/library/abstract.html?uid=37804

Hadjivassiliou, M., Boscolo, S., Tongiorgi, E., Grünewald, R.A., Sharrack, B., Sanders, D.S., ... Davies-Jones, G.A.B. (2008). Cerebellar ataxia as a possible organ-specific autoimmune disease. Movement disorders, 23 (10), 1370-1377. http://doi.org/10.1002/mds.22129

Hadjivassiliou, M., Sanders, D.S., Woodroofe, N., Williamson, C., & Grünewald, R.A. (2008). Gluten ataxia. The Cerebellum, 7 (3), 494-498. http://doi.org/10.1007/s12311-008-0052-x

Hadjivassiliou, M., Aeschlimann, P., Strigun, A., Sanders, D.S., Woodroofe, N., & Aeschlimann, D. (2008). Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase. Annals of neurology, 64 (3), 332-343. http://doi.org/10.1002/ana.21450

Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J.T., Bunning, R.A., ... Woodroofe, M.N. (2007). Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat. Biochemical Society Transactions, 35 (4), 692. http://doi.org/10.1042/BST0350692

Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A., ... Woodroofe, N. (2006). ADAMTS -1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. Brain research, 1088 (1), 19-30. http://doi.org/10.1016/j.brainres.2006.02.136

Hadjivassiliou, M., Mäki, M., Sanders, D.S., Williamson, C.A., Grünewald, R.A., Woodroofe, N.M., & Korponay-Szabó, I.R. (2006). Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia. Neurology, 66 (3), 373-377. http://doi.org/10.1212/01.wnl.0000196480.55601.3a

Cross, A.K., Haddock, G., Surr, J., Plumb, J., Buttle, D.J., & Woodroofe, N. (2005). Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis. Journal of autoimmunity, 26 (1), 16-23. http://doi.org/10.1016/j.jaut.2005.09.026

Haddock, G., Cross, A.K., Plumb, J., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2005). Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter. Multiple Sclerosis, 12 (4), 386-396. http://doi.org/10.1191/135248506ms1300oa

Plumb, J., McQuaid, S., Cross, A.K., Surr, J., Haddock, G., Bunning, R.A.D., & Woodroofe, M.N. (2005). Upregulation of ADAM-17 expression in active lesions in multiple sclerosis. Multiple Sclerosis, 12 (4), 375-385. http://doi.org/10.1191/135248506ms1276oa

Plumb, J., Cross, A.K., Surr, J., Haddock, G., Smith, T., Bunning, R.A.D., & Woodroofe, M.N. (2005). ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 164 (1-2), 1-9. http://doi.org/10.1016/j.jneuroim.2005.02.021

Hadjivassiliou, M., Williamson, C.A., & Woodroofe, N. (2004). The immunology of gluten sensitivity: Beyond the gut. Trends in Immunology, 25 (11), 578-582. http://doi.org/10.1016/j.it.2004.08.011

Harkness, K.A., Sussman, J.D., Davies-Jones, G.A.B., Greenwood, J., & Woodroofe, M.N. (2003). Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cells. Journal of Neuroimmunology, 142 (1-2), 1-9. http://doi.org/10.1016/S0165-5728(03)00251-0

Kemp, H.E., Metcalfe, R.A., Smith, K.A., Woodroofe, M.N., Watson, P.F., & Weetman, A.P. (2003). Detection and localization of chemokine gene expression in autoimmune thyroid disease. Clinical endocrinology, 59 (2), 207-213. http://doi.org/10.1046/j.1365-2265.2003.01824.x

Mahad, D.J., Lawry, J., Howell, S.J.L., & Woodroofe, M.N. (2003). Longitudinal study of chemokine receptor expression on peripheral lymphocytes in multiple sclerosis: CXCR3 upregulation is associated with relapse. Multiple Sclerosis, 9 (2), 189-198. http://doi.org/10.1191/1352458503ms899oa

Hadjivassiliou, M., Grünewald, R., Sharrack, B., Sanders, D., Lobo, A., Williamson, C., ... Davies-Jones, A. (2003). Gluten ataxia in perspective: Epidemiology, genetic susceptibility and clinical characteristics. Brain, 126 (3), 685-691. http://doi.org/10.1093/brain/awg050

Mahad, D.J., Howell, S.J.L., & Woodroofe, N. (2002). Expression of chemokines in cerebrospinal fluid and serum of patients with chronic inflammatory demyelinating polyneuropathy. Journal of neurology neurosurgery and psychiatry, 73 (3), 320-323. http://doi.org/10.1136/jnnp.73.3.320

Hadjivassiliou, M., Boscolo, S., Davies-Jones, G.A.B., Grünewald, R.A., Not, T., Sanders, D.S., ... Woodroofe, N.M. (2002). The humoral response in the pathogenesis of gluten ataxia. Neurology, 58 (8), 1221-1226. http://doi.org/10.1212/WNL.58.8.1221

Mahad, D.J., Howell, S.J.L., & Woodroofe, M.N. (2002). Expression of chemokines in the CSF and correlation with clinical disease activity in patients with multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry, 72 (4), 498-502. http://doi.org/10.1136/jnnp.72.4.498

Kieseier, B.C., Tani, M., Mahad, D., Oka, N., Ho, T., Woodroofe, N., ... Hartung, H.-.P. (2001). Chemokines and chemokine receptors in inflammatory demyelinating neuropathies: a central role for IP-10. Brain, 125 (4), 823-834. http://doi.org/10.1093/brain/awf070

Cross, A.K., & Woodroofe, M.N. (2001). Immunoregulation of microglial functional properties. Microscopy Research and Technique, 54 (1), 10-17. http://doi.org/10.1002/jemt.1115

Goddard, D.R., Bunning, R.A.D., & Woodroofe, M.N. (2001). Astrocyte and endothelial cell expression of ADAM 17 (TACE) in adult human CNS. Glia, 34 (4), 267. http://doi.org/10.1002/glia.1060

John, G.R., Simpson, J.E., Woodroofe, N., Lee, S.C., & Brosnan, C.F. (2001). Extracellular nucleotides differentially regulate interleukin-1 signaling in primary human astrocytes: implications for inflammatory gene expression. Journal of Neuroscience, 21 (12), 4134-4142. http://www.jneurosci.org/cgi/content/full/21/12/4134

De Groot, C.J.A., & Woodroofe, M.N. (2001). The role of chemokines and chemokine receptors in CNS inflammation. Progress in Brain Research, 132, 533-544. http://doi.org/10.1016/S0079-6123(01)32101-5

Woodroofe, N., Cross, A.K., Harkness, K., & Simpson, J.E. (2000). The role of chemokines in the pathogenesis of multiple sclerosis. Advances in Experimental Medicine and Biology, 468, 135-150.

Simpson, J., Rezaie, P., Newcombe, J., Cuzner, M.L., Male, D., & Woodroofe, M.N. (2000). Expression of the β-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue. Journal of Neuroimmunology, 108 (1-2), 192-200. http://doi.org/10.1016/S0165-5728(00)00274-5

Simpson, J.E., Newcombe, J., Cuzner, M.L., & Woodroofe, M.N. (2000). Expression of the interferon-γ-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions. Neuropathology and Applied Neurobiology, 26 (2), 133-142. http://doi.org/10.1046/j.1365-2990.2000.026002133.x

Harkness, K.A.C., Adamson, P., Sussman, J.D., Davies-Jones, G.A.B., Greenwood, J., & Woodroofe, M.N. (2000). Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium. Brain, 123 (4), 698-709. http://doi.org/10.1093/brain/123.4.698

Cross, A.K., & Woodroofe, M.N. (1999). Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro. GLIA, 28 (3), 183-189. http://doi.org/10.1002/(SICI)1098-1136(199912)28:3<183::AID-GLIA2>3.0.CO;2-3

Cross, A.K., & Woodroofe, M.N. (1999). Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro. GLIA, 28 (3), 183-189. http://doi.org/10.1002/(SICI)1098-1136(199912)28:3<183::AID-GLIA2>3.0.CO;2-3

Cross, A.K., & Woodroofe, M.N. (1999). Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. JOURNAL OF NEUROSCIENCE RESEARCH, 55 (1), 17-23. http://doi.org/10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3>3.0.CO;2-J

Cross, A.K., & Woodroofe, M.N. (1999). Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. Journal of Neuroscience Research, 55 (1), 17-23. http://doi.org/10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3>3.0.CO;2-J

Simpson, J.E., Newcombe, J., Cuzner, M.L., & Woodroofe, M.N. (1998). Expression of monocyte chemoattractant protein-1 and other β- chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. Journal of Neuroimmunology, 84 (2), 238-249. http://doi.org/10.1016/S0165-5728(97)00208-7

Loughlin, A.J., & Woodroofe, M.N. (1996). Inhibitory effect of interferon-γ on LPS-induced interleukin 1β production by isolated adult rat brain microglia. Neurochemistry International, 29 (1), 77-82. http://doi.org/10.1016/0197-0186(95)00135-2

Windhagen, A., Newcombe, J., Dangond, F., Strand, C., Woodroofe, M.N., Cuzner, M.L., & Hafler, D.A. (1995). Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. Journal of Experimental Medicine, 182 (6), 1985-1996. http://doi.org/10.1084/jem.182.6.1985

Woodroofe, M.N. (1995). Cytokine production in the central nervous system. Neurology, 45 (6 Suppl 6), S6-10. http://doi.org/10.1212/wnl.45.6_suppl_6.s6

Woodroofe, M.N., Dantzer, R., Gutierrez, E.G., Banks, W.A., Kastin, A.J., Banks, W.A., ... Brown, A. (1995). Cytokine production in the central nervous system. Neurology, 45 (6), S6-S10. http://doi.org/10.1212/wnl.45.6_suppl_6.s6

Brosnan, C.F., Cannella, B., Battistini, L., Raine, C.S., Mosmann, T.R., Coffman, R.L., ... Dhib-Jalbut, S. (1995). Cytokine localization in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species. Neurology, 45 (6), S16-S21. http://doi.org/10.1212/wnl.45.6_suppl_6.s16

Cuzner, M.L., Loughlin, A.J., Mosley, K., & Woodroofe, M.N. (1994). The role of microglia macrophages in the processes of inflammatory demyelination and remyelination. Neuropathology and Applied Neurobiology, 20 (2), 200-201.

Zoukos, Y., Kidd, D., Woodroofe, M.N., Kendall, B.E., Thompson, A.J., & Cuzner, M.L. (1994). Increased expression of high affinity IL-2 receptors and β-adrenoceptors on peripheral blood mononuclear cells is associated with clinical and MRI activity in multiple sclerosis. Brain, 117 (2), 307-315. http://doi.org/10.1093/brain/117.2.307

Loughlin, A.J., Woodroofe, M.N., Cuzner, M.L., Honegger, P., Comte, V., & Matthieu, J. (1994). Myelin basic protein content of aggregating rat brain cell cultures treated with cytokines and/or demyelinating antibody: Effects of macrophage enrichment. Journal of Neuroscience Research, 37 (5), 647-653. http://doi.org/10.1002/jnr.490370512

Woodroofe, M.N., Cuzner, M.L., & Ironside, J.W. (1994). In situ hybridization in neuropathology. Neuropathology and Applied Neurobiology, 20 (6), 562-572. http://doi.org/10.1111/j.1365-2990.1994.tb01010.x

Woodroofe, M.N., & Cuzner, M.L. (1993). Cytokine mrna expression in inflammatory multiple sclerosis lesions: Detection by non-radioactive in situ hybridization. Cytokine, 5 (6), 583-588. http://doi.org/10.1016/S1043-4666(05)80008-0

Loughlin, A.J., Woodroofe, M.N., & Cuzner, M.L. (1993). Modulation of interferon-γ-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-β1, interleukin-4, noradrenaline and glucocorticoids. Immunology, 79 (1), 125-130.

Loughlin, A.J., Woodroofe, M.N., & Cuzner, M.L. (1992). Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide: Effects on interferon-gamma induced activation. Immunology, 75 (1), 170-175.

Newcombe, J., Hawkins, C.P., Henderson, C.L., Patel, H.A., Woodroofe, M.N., Hayes, G.M., ... Mcdonald, W.I. (1991). Histopathology of multiple sclerosis lesions detected by magnetic resonance imaging in unfixed postmortem central nervous system tissue. Brain, 114 (2), 1013-1023. http://doi.org/10.1093/brain/114.2.1013

Woodroofe, M.N., Sarna, G.S., Wadhwa, M., Hayes, G.M., Loughlin, A.J., Tinker, A., & Cuzner, M.L. (1991). Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. Journal of Neuroimmunology, 33 (3), 227-236. http://doi.org/10.1016/0165-5728(91)90110-S

Woodroofe, M.N., Hayes, G.M., & Cuzner, M.L. (1989). Fc receptor densisty, MHC antigen expression and superoxide production are increased in interferon-gamma-treated microglia isolated from adult rat brain. Immunology, 68 (3), 421-426.

Cuzner, M.L., Hayes, G.M., Newcombe, J., & Woodroofe, M.N. (1988). The nature of inflammatory components during demyelination in multiple sclerosis. Journal of Neuroimmunology, 20 (2-3), 203-209. http://doi.org/10.1016/0165-5728(88)90161-0

Hayes, G.M., Woodroofe, M.N., & Cuzner, M.L. (1988). Characterisation of microglia isolated from adult human and rat brain. Journal of Neuroimmunology, 19 (3), 177-189. http://doi.org/10.1016/0165-5728(88)90001-X

HAYES, G.M., WOODROOFE, M.N., & CUZNER, M.L. (1988). Microglia Express MHC Class II in Normal and Demyelinating Human White Matter. Annals of the New York Academy of Sciences, 540 (1), 501-503. http://doi.org/10.1111/j.1749-6632.1988.tb27150.x

Hayes, G.M., Woodroofe, M.N., & Cuzner, M.L. (1987). Microglia are the major cell type expressing MHC class II in human white matter. Journal of the Neurological Sciences, 80 (1), 25-37. http://doi.org/10.1016/0022-510X(87)90218-8

Woodroofe, M.N., Bellamy, A.S., Feldmann, M., Davison, A.N., & Cuzner, M.L. (1986). Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth. Journal of the Neurological Sciences, 74 (2-3), 135-152. http://doi.org/10.1016/0022-510X(86)90100-0

Newcombe, J., Woodroofe, M.N., & Cuzner, M.L. (1986). Distribution of Glial Fibrillary Acidic Protein in Gliosed Human White Matter. Journal of Neurochemistry, 47 (6), 1713-1719. http://doi.org/10.1111/j.1471-4159.1986.tb13079.x

Woodroofe, M.N., Tunnacliffe, A., Pym, B., Goodfellow, P.N., & Walsh, F.S. (1984). Human muscle cell surface antigen 16.3A5 is encoded by a gene on chromosome 11. Somatic Cell and Molecular Genetics, 10 (5), 535-540. http://doi.org/10.1007/BF01534858

Lim, S.S., Woodroofe, M.N., & Lemanski, L.F. (1983). An analysis of contractile proteins in developing chick heart by SDS polyacrylamide gel electrophoresis and electron microscopy. Journal of Embryology and Experimental Morphology, VOL. 77, 1-14.

Woodroofe, M.N., & Lemanski, L.F. (1981). Two actin variants in developing axolotl heart. Developmental Biology, 82 (1), 172-179. http://doi.org/10.1016/0012-1606(81)90439-5

Woodroofe, M.N., & Butterworth, P.J. (1979). Evidence for the importance of arginine residues in pig kidney alkaline phosphatase. The Biochemical journal, 181 (1), 137-142. http://doi.org/10.1042/bj1810137

Woodroofe, M.N., & Butterworth, P.J. (1978). Chemical modification studies on pig kidney alkaline phosphatase. Biochemical Society Transactions, 6 (3), 562-564. http://doi.org/10.1042/bst0060562

Conference papers

Salman, M., Kitchen, P., Heath, P., Belli, A., Woodroofe, M.N., Bill, R., ... Conner, M. (2017). Location matters: the role of calmodulin-mediated AQP4 translocation in human astrocyte response to hypoxia and mild hypothermia. JOURNAL OF NEUROCHEMISTRY, 142, 85.

Salman, M., Kitchen, P., Heath, P., Bill, R., Conner, A., Woodroofe, M.N., & Conner, M. (2017). Location matters: the role of calmodulin mediated AQP4 translocation in the human astrocyte response to hypoxia and mild hypothermia. GLIA, 65, E329.

Abuneeza, E., Cross, A., Haddock, G., Bunning, R., & Woodroofe, N. (2014). Expression of ADAMTS-9 in the central nervous system in multiple sclerosis and its relationship to cleavage of aggrecan and versican. Journal of Neuroimmunology, 275 (1-2), 131-132. http://doi.org/10.1016/j.jneuroim.2014.08.353

Bokhamada, H.K., Woodroofe, M.N., Jones, T.H., Small, S.H., Kay, W., & Dalton, C.F. (2013). INVESTIGATION OF THE EFFECT OF TESTOSTERONE TREATMENT ON THE EXPRESSION OF CHEMOKINE RECEPTORS IN MONOCYTE/MACROPHAGE THP-1 CELL LINE. ATHEROSCLEROSIS, 231 (2), E6. http://doi.org/10.1016/j.atherosclerosis.2013.07.024

Battle, R., Woodroofe, M.N., Clench, M., Bradshaw, R., Harrison, P., & Clark, B. (2013). A bioinformatics and proteomic approach for the identification of peptides derived from HLA class I molecules and presented by HLA-A*02. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 40 (5), 414.

Battle, R., Woodroofe, M.N., Clench, M., & Clark, B. (2013). HLA-Class I leader peptide sequence mismatches between renal transplant donors and recipients are associated with a reduction in allograft function within the first 12 months post transplant. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 40 (5), 403.

Woodroofe, M.N., Sinagra, M., Bunning, R., Bolton, C., & Azzouz, M. (2013). EFFECT OF SILENCING ADAM17 EXPRESSION BY AN ADENOVIRAL VECTOR-MEDIATED RNA INTERFERENCE APPROACH IN CHRONIC RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. GLIA, 61, S43.

Bradford, C.M. (2012). The role of citrullination of central nervous system proteins in multiple sclerosis.

Bradford, C.M. (2012). The role of citrullination of central nervous system proteins in multiple sclerosis.

Waller, R., Heath, P.R., Woodroofe, M.N., Francese, S., Wharton, S.B., Ince, P.G., ... Simpson, J.E. (2012). Microarray analysis of the astrocyte transcriptome in normal appearing white matter in multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, 253 (1-2), 54.

Frentzou, G.A., Kamara, C., Harkness, K.A., Haddock, G., Doyle, C., Taylor, M., ... Randall, M. (2010). REDUCED ADAMTS-13 ACTIVITY LEVELS IN PARTIAL ANTERIOR CIRCULATION TRANSIENT ISCHAEMIC ATTACK PATIENTS COMPARED TO NONSTROKE CONTROLS. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 81 (11), E69. http://doi.org/10.1136/jnnp.2010.226340.207

Kelly, D.M., Sellers, D.J., Woodroofe, M.N., Jones, T.H., & Channer, K.S. (2010). Effect of Testosterone on Inflammatory Markers in Development of Early Atherogenesis in the Testicular Feminised Mouse (Tfm) Model. ENDOCRINE REVIEWS, 31 (3).

Woodroofe, N.W., Sellers, D., Channer, K.S., & Kelly, D.M. (2008). Investigating the role of testosterone and inflammation in atherosclerosis. Immunology, 125 (1), 116-117. http://doi.org/10.1111/j.1365-2567.2008.02826.x

Fouillet, A., Romero, I.A., Woodroofe, M.N., & Medimond, (2007). Astrocytes regulate CCL2 level in CCR2-independent way. PROCEEDINGS OF THE VIII EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, 79-+.

Haddock, G., Cross, A.K., Allan, S., Bunning, R.A.D., Buttle, D.J., & Woodroofe, M.N. (2007). Changes in brain expression of chondroitin sulphate proteoglycans following transient middle cerebral artery occlusion in the rat. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 88 (6), A92.

Dhungana, S., Woodroofe, M.N., Sharrack, B., Howell, S.J., & Price, S.E. (2007). Cerebrospinal fluid and serum cytokine profile in patients with idiopathic intracranial hypertension. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 78 (9), 1025.

Suliman, O., Sharrack, B., Howell, S., Price, S., & Woodroofe, M.N. (2007). Longitudinal study of expression of CCL2 and CXCL10 in the serum of patients with multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 78 (9), 1036.

Hurst, L.A., Bunning, R.A.D., Sharrack, B., & Woodroofe, M.N. (2007). A functional role for ADAM-17 in the pathogenesis of multiple sclerosis. IMMUNOLOGY, 120, 32.

Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J., Bunning, R.A.D., ... Woodroofe, M.N. (2007). Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat. Biochemical Society Transactions, 35 (4), 692-694. http://doi.org/10.1042/BST0350692

Suliman, O., Howell, S.J., Lawry, J., Sharrack, B., & Woodroofe, M.N. (2006). Longitudinal study of chemokine receptor expression on CD4(+) and CD8(+) T cells and CD14(+) monocytes in patients with relapsing and remitting multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 77 (12), 1399.

Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A.D., ... Woodroofe, M.N. (2006). ADAMTS-1 and-4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by cytokines in astrocytes and endothelial cell cultures. JOURNAL OF NEUROIMMUNOLOGY, 178, 249.

Reid, M.J., Allan, S., Cross, A.K., Woodroofe, M.N., Buttle, D.J., & Bunning, R.A.D. (2006). ADAMTS-9 is upregulated at the mRNA level following middle cerebral artery occlusion in rats. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 87 (1), A28.

Laird, S.M., Calverley, H., Audley, A.M., Scott, M., Li, T.C., & Woodroofe, M.N. (2005). Expression of CXCR1 and CXCR3 in human endometrium; Effects of their ligands on endometrial cell function. PLACENTA, 26 (8-9), A28.

Reid, M.J., Cross, A.K., Woodroofe, M.N., Buttle, D.J., & Bunning, R.A.D. (2005). Pro-inflammatory cytokines modulate a disintegrin and metalloproteinase domain with thrombospondin motif S-9 mRNA expression in human glial cell lines. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 86 (6), A81-A82.

Denney, H., Clench, M., & Woodroofe, M.N. (2005). Investigations into the significance of the truncation of chemokines CCL2 and CXCL10 by MMP2, MMP9, and CD26, in multiple sclerosis. IMMUNOLOGY, 116, 42.

Hadjivassiliou, M., Williamson, C.A., Grunewald, R.A., & Woodroofe, M.N. (2004). Glutamic acid decarboxylase as a target antigen in gluten sensitivity: the link to neurological manifestations? JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 97.

Williamson, C.A., Grunewald, R.A., Woodroofe, M.N., & Hadjivassiliou, M. (2004). An investigation into the specificity of circulating anti-cerebellar antibodies involved in the humoral immune response associated with gluten ataxia. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 97.

Haddock, G., Cross, A.K., Bunning, R.A.D., Plumb, J., Surr, J., Buttle, D.J., ... Woodroofe, M.N. (2004). Expression of ADAMTS-1, -4 -5 and TIMP-3 in different stages of experimental autoimmune encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 58.

Plumb, J., Bunning, R.A.D., & Woodroofe, M.N. (2003). Cytokine regulation of TACE and TIMP 3 production by astrocyte and endothelial cells. GLIA, 42-43.

Haddock, G., Cross, A.K., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2003). Expression of ADAMTS-1,-4-5 and TIMP-3 in central nervous system cell lines: Possible role in CNS physiology and pathology. GLIA, 33.

Williamson, C.A., Grunewald, R.A., Woodroofe, M.N., & Hadjivassiliou, M. (2002). An investigation of anti-cerebellar antibodies in gluten ataxia. GLIA, S77.

Gill, K.A., & Woodroofe, M.N. (2002). Effect of extracellular matrix components on the presentation of chemokines and migration of microglia and astrocyte cell lines. GLIA, S42-S43.

Mahad, D., Oates, K., Williams, C., Grunewald, R., Howell, S.J.L., Woodroofe, M.N., & Hajivassiliou, M. (2002). Gluten ataxia is immune mediated. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 72 (1), 140.

Hadjivassiliou, M., Grunewald, R.A., Davies-Jones, G.A.B., Simpson, J.E., Williamson, C.A., Woodroofe, M.N., ... Not, T. (2001). Humoral response in the pathogenesis of gluten ataxia. ANNALS OF NEUROLOGY, 50 (3), S37.

Simpson, J.E., & Woodroofe, M.N. (2001). Inflammation in the central nervous system in multiple sclerosis: The role of chemokines and their receptors. Inflammopharmacology, 9 (1-2), 23-33. http://doi.org/10.1163/156856001300248290

Mahad, D.J., Woodroofe, M.N., & Howell, S.J. (2001). Cerebrospinal fluid concentrations of chemokines and Th1 lymphocytes in patients with multiples sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 70 (2), 274.

Mahad, D.J., Woodroofe, M.N., & Howell, S.J. (2000). Chemokine expression in cerebrospinal fluid of multiple sclerosis. ANNALS OF NEUROLOGY, 48 (3), 452.

Woodroofe, M.N. (1996). Cytokine expression by microglia in vitro and in the central nervous system in multiple sclerosis. JOURNAL OF PHYSIOLOGY-LONDON, 493P, S45-S46.

CUZNER, M.L., WOODROOFE, M.N., & LOUGHLIN, A.J. (1993). REGULATION OF THE FUNCTIONAL-PROPERTIES OF MICROGLIA BY CYTOKINES. JOURNAL OF NEUROCHEMISTRY, 61, S238.

HAYES, G.M., WOODROOFE, M.N., & CUZNER, M.L. (1987). THE IDENTIFICATION OF MYELIN BASIC-PROTEIN BY CLASS-II+ MICROGLIA IN WHITE MATTER FROM MULTIPLE-SCLEROSIS BRAIN. JOURNAL OF NEUROIMMUNOLOGY, 16 (1), 75. http://doi.org/10.1016/0165-5728(87)90242-6

WALSH, F.S., MOORE, S.E., WOODROOFE, M.N., HURKO, O., NAYAK, R., & BROWN, S.M. (1983). DEVELOPMENTALLY REGULATED ANTIGENS OF HUMAN-MUSCLE. HYBRIDOMA, 2 (2), 243.

WOODROOFE, M.N., MOORE, S., DHUT, S., & WALSH, F.S. (1982). CHARACTERIZATION OF HUMAN-MUSCLE FIBER TYPE SPECIFIC ANTIGENS USING MONOCLONAL-ANTIBODIES. BIOLOGY OF THE CELL, 45, 272.

LIMSPIKER, S., WOODROOFE, M.N., & LEMANSKI, L.F. (1981). ANALYSIS OF MUSCLE PROTEINS IN DEVELOPING CHICK HEART. JOURNAL OF CELL BIOLOGY, 91 (2), A349.

WOODROOFE, M.N., & LEMANSKI, L.F. (1980). ACTIN IN CARDIAC MUTANT AND NORMAL AXOLOTL HEARTS. JOURNAL OF CELL BIOLOGY, 87 (2), A266.

WOODROOFE, M.N., LIMSPIKER, S., & LEMANSKI, L.F. (1980). CHICK HEART DEVELOPMENT ANALYZED BY 2 DIMENSIONAL GEL-ELECTROPHORESIS AND ELECTRON-MICROSCOPY. JOURNAL OF CELL BIOLOGY, 87 (2), A266.

Book chapters

Woodroofe, N., & Amor, S. (2014). Immune privilege of the brain. In Woodroofe, N., & Amor, S. (Eds.) Neuroinflammation and CNS Disorders. (pp. 1-8). Wiley: http://doi.org/10.1002/9781118406557.ch1

Woodroofe, N., & Amor, S. (2014). Immune privilege of the brain. In Woodroofe, N., & Amor, S. (Eds.) Neuroinflammation and CNS Disorders. (pp. 1-8). Wiley: http://doi.org/10.1002/9781118406557.ch1

Bradford, C., Nicholas, A.P., Cross, A.K., & Woodroofe, N. (2013). Deimination in Multiple Sclerosis and experimental autoimmune encephalomyelitis. In Nicholas, A.P., & Bhattacharya, S.K. (Eds.) Protein deimination in human health and disease. (pp. 165-185). Springer: http://doi.org/10.1007/978-1-4614-8317-5_10

Woodroofe, M.N., & Bunning, R.A.D. (2005). Proteases and peptidases in EAE. In Experimental Models of Multiple Sclerosis. (pp. 391-413). http://doi.org/10.1007/0-387-25518-4_19

Books

Woodroofe, N., & Amor, S. (2014). Neuroinflammation and CNS Disorders. http://doi.org/10.1002/9781118406557

Theses / Dissertations

Salman, M. (2018). The mechanisms of aquaporin expression and translocation in cerebral pathologies. (Doctoral thesis). Supervised by Woodroofe, N., & Conner, M. http://doi.org/10.7190/shu-thesis-00010

Sholademi, B.A. (2017). Identification and reduction of pre-analytical errors in clinical chemistry through expert advice. (Doctoral thesis). Supervised by Woodroofe, N. http://doi.org/10.7190/shu-thesis-00033

Mounsey, K.L. (2016). Immunophenotyping as a profiling tool in human leucocyte antigen incompatible renal transplantation. (Doctoral thesis). Supervised by Woodroofe, N.

Abuneeza, E. (2015). Changes in chondroitin sulphate proteoglycan in multiple sclerosis : A role for ADAMTS-9. (Doctoral thesis). Supervised by Woodroofe, N., Bunning, R., Cross, A., & Haddock, G.

Battle, R. (2014). Investigating the role of HLA class I derived peptide in alloreactivity. (Doctoral thesis). Supervised by Woodroofe, N., & Clark, B.

Bokhamada, H. (2014). The effect of testosterone on factors associated with diabetes, atherosclerosis and obesity. (Doctoral thesis). Supervised by Dalton, C., Woodroofe, N., & Jones, H.

Chen, Y.-.F. (2014). Creating meaningful bodily expression in virtual worlds : Inquiring methods for designers. (Doctoral thesis). Supervised by Rust, C., & Woodroofe, N.

Barraclough, J. (2012). Pharmacogenetic, clinical and demographic factors in the management of warfarin therapy. (Doctoral thesis). Supervised by Woodroofe, N.

Hart, P.J. (2012). MALDI-MS investigation of skin and its response to irritants and sensitisers. (Doctoral thesis). Supervised by Clench, M., Woodroofe, N., & Francese, S.

Kelly, D.M. (2010). Investigation of the mechanisms underlying the development of atherosclerosis. (Doctoral thesis). Supervised by Woodroofe, N., & Sellers, D.

Williams, M. (2010). The effect of anti-D immunoglobulin administration on plasma cytokine profiles. (Doctoral thesis). Supervised by Lubenko, A., Norfolk, D., Soltani, H., & Woodroofe, N.

Hurst, L.A. (2009). CNS endothelium expression of ADAM-17 and its role in multiple sclerosis pathogenesis. (Doctoral thesis). Supervised by Woodroofe, N., & Bunning, R.

Moin, M. (2009). Synthesis of curcuminoids as non-steroidal anti-inflammatory drugs. (Doctoral thesis). Supervised by Khan, A., & Woodroofe, N.

Vahabi, B. (2009). Investigation of the physiology and pathophysiology of streptozotocin-induced diabetic rat bladder. (Doctoral thesis). Supervised by Sellers, D., Mckay, N., Lawson, K., & Woodroofe, N.

Denney, H.A. (2008). Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis. (Doctoral thesis). Supervised by Woodroofe, N., Bunning, R., & Clench, M.

Reid, M.J. (2007). Investigation of ADAMTS-9 expression in models of central nervous system inflammation. (Doctoral thesis). Supervised by Bunning, R., Battle, D., & Woodroofe, N.

Welbourn, J.T. (2007). Photophatase and tensin homologue deleted on chromosome ten (PTEN) gene mutations in haematological malignancies. (Doctoral thesis). Supervised by Blair, M., & Woodroofe, N.

Plumb, J. (2005). The role of the CNS endothelium in the pathogenesis of multiple sclerosis. (Doctoral thesis). Supervised by Woodroofe, N., & Bunning, R.

Williamson, C.A. (2003). An investigation of the humoral immune response in patients with gluten ataxia. (Doctoral thesis). Supervised by Woodroofe, N., & Hadjivasiliou, M.

Other activities

- Committee member Eurpean School of Neuroimmunology
- Committee member International Society of Neuroimmunology

Postgraduate supervision

I have supervised PhD students both at Sheffield Hallam University and The University of Sheffield, including clinicians, with most of these focussed on multiple sclerosis research. I have also supervised professional doctorate students working in NHS pathology laboratories as well as at the NHS Blood Transfusion Service laboratories.

Media

Nicola was the Head of the University's Biomolecular Sciences Research Centre until the end of December 2018 and has worked within biomedical research for over 30 years, with particular focus on multiple sclerosis (MS). Nicola's main interest is in the study of post-mortem brain tissue using pathological and immunological techniques to get an understanding of the immune mechanisms within the brain of an MS patient. Nicola chairs the Women Professors' Group which seeks to support and inspire female academics to advance their careers to professorial level and she is also a champion of women in science.

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