Skip to content

Dr Alex Hamilton BSc, PhD, FHEA

Senior Lecturer in Physical Chemistry


Summary

I was appointed as a lecturer in Physical Chemistry at Sheffield Hallam University after completing my MChem in Chemistry at Swansea University, a PhD in Structural Chemistry at Bristol University and postdoctoral stays in Spain (ICIQ) and New Zealand (Massey University). My teaching covers all aspects of Physical Chemistry. My research group apply state-of-the-art computational simulations to understand reaction mechanisms and design novel catalysts.

About

I was appointed as a lecturer in Physical Chemistry at Sheffield Hallam University after completing my MChem in Chemistry at Swansea University, a PhD in Structural Chemistry at Bristol University and postdoctoral stays in Spain (ICIQ) and New Zealand (Massey University).

My teaching covers all aspects of Physical Chemistry, from thermodynamics, phase diagrams and kinetics to statistical mechanics and group theory. My research group apply state-of-the-art computational simulations (Density Functional Theory methods) to understand catalytic reaction mechanisms and design novel catalysts. My group collaborate with a number of national and international experimental researchers working on a variety of different systems. An underlying theme to all systems that interest me is the importance of non-covalent interactions and how this underpins so much important chemistry.

Computational and Structural Chemistry

Teaching

Chemistry

MChem & BSc Chemistry

Extended Degree in Biosciences & Chemistry

Research

Catalyst design through database mining and computational chemistry
Organometallic homogeneous catalysis is the workhorse of fine chemical synthesis. The shear variety and high level of tunability means these catalytic complexes have found application in pharmaceuticals, agrochemicals manufacture and beyond. Even with all the interest in organometallic complexes, the holy grail of 'designer catalysts' is still some way off. Hemi-labile ligands are particularly interesting as, due to their inherent flexibility, they have the ability to control the number of coordination sites around the metal centre. Understanding and manipulating this flexibility can lead to new reaction pathways and novel products.

Elucidation of catalytic reactions mechanisms
In collaboration with a number of external research groups we have an interest in solving the complex mechanisms involved in catalysis, both organo- and transition metal orientated. Reactions of interest are, but not limited to, C-H activation, hydrogenation and hydrocyanation.

Non-covalent interactions in supramolecular chemistry
Supramolecular chemistry finds application in wide and diverse areas of chemistry, biology, materials and environmental science. The understanding of the non-covalent interactions which govern the structure and activity of the supramolecular species is key to optimising their application. We have particular interest in systems applied to catalysis and chemical sensing.

Collaborators:

Dr. Andy Chapman, Kingston University, UK
Dr. Louis Adiaenssens, University of Lincoln, UK
Prof Mark Waterland, Massey University, NZ
Prof Gareth Rowlands, Massey University, NZ
Prof Carles Bo, ICIQ, ES

Publications

Kenny, A., Pisarello, A., Bird, A., Chirila, P.G., Hamilton, A., & Whiteoak, C. (2018). A challenging redox neutral Cp*Co(III)-catalysed alkylation of acetanilides with 3-buten-2-one: synthesis and key insights into the mechanism through DFT calculations. Beilstein journal of organic chemistry, 14, 2366-2374. http://doi.org/10.3762/bjoc.14.212

Chirila, P., Skibinski, L., Miller, K., Hamilton, A., & Whiteoak, C. (2018). Towards a Sequential One-Pot Preparation of 1,2,3-Benzotriazin-4(3H)-ones Employing a Key Cp*Co(III)-catalyzed C-H Amidation Step. Advanced Synthesis & Catalysis, 360 (12), 2324-2332. http://doi.org/10.1002/adsc.201800133

Chirila, P.G., Adams, J., Dirjal, A., Hamilton, A., & Whiteoak, C. (2018). Cp*Co(III)-Catalyzed coupling of benzamides with α,β-unsaturated carbonyl compounds: Preparation of aliphatic ketones and azepinones. Chemistry : A European Journal, 24 (14), 3584-3589. http://doi.org/10.1002/chem.201705785

Lister, J.M., Carreira, M., Haddow, M.F., Hamilton, A., McMullin, C.L., Orpen, A.G., ... Stennett, T.E. (2014). Unexpectedly high barriers to M–P rotation in tertiary phobane complexes : PhobPR behavior that is commensurate with tBu2PR. Organometallics, 33 (3), 702-714. http://doi.org/10.1021/om400980e

Tsoureas, N., Hamilton, A., Haddow, M.F., Harvey, J.N., Orpen, A.G., & Owen, G.R. (2013). Insight into the hydrogen migration processes involved in the formation of metal–borane complexes : importance of the third arm of the scorpionate ligand. Organometallics, 32 (9), 2840-2856. http://doi.org/10.1021/om4002389

Hamilton, A., Gicquel, M., Ballester, P., & Bo, C. (2013). Mechanisms of catalysis in confined spaces: hydrogenation of norbornadiene with a rhodium complex included in a self-folding cavitand. Current Organic Chemistry, 17 (14), 1499-1506. http://doi.org/10.2174/1385272811317140006

Owen, G.R., Gould, P.H., Moore, A., Dyson, G., Haddow, M.F., & Hamilton, A. (2013). Copper and silver complexes bearing flexible hybrid scorpionate ligand mpBm. Dalton Transactions, 42 (31), 11074-11081. http://doi.org/10.1039/C3DT51286J

Moran, A., Hamilton, A., Bo, C., & Melchiorre, P. (2013). A mechanistic rationale for the 9-amino(9-deoxy)epi cinchona alkaloids catalyzed asymmetric reactions via iminium ion activation of enones. Journal of the American Chemical Society, 135 (24), 9091-9098. http://doi.org/10.1021/ja404784t

Pintre, I.C., Pierrefixe, S., Hamilton, A., Valderrey, V., Bo, C., & Ballester, P. (2012). Influence of the solvent and metal center on supramolecular chirality induction with bisporphyrin tweezer receptors. Strong metal modulation of effective molarity values. Inorganic chemistry, 51 (8), 4620-4635. http://doi.org/10.1021/ic202515v

Tsoureas, N., Nunn, J., Bevis, T., Haddow, M.F., Hamilton, A., & Owen, G.R. (2011). Strong agostic-type interactions in ruthenium benzylidene complexes containing 7-azaindole based scorpionate ligands. Dalton Transactions, 40 (4), 951-958. http://doi.org/10.1039/C0DT01148G

Dyson, G., Zech, A., Rawe, B.W., Haddow, M.F., Hamilton, A., & Owen, G.R. (2011). Scorpionate ligands based on 2-Mercaptopyridine : a ligand with a greater propensity to sting? Organometallics, 30 (21), 5844-5850. http://doi.org/10.1021/om200694r

Owen, G.R., Gould, P.H., Hamilton, A., & Tsoureas, N. (2010). Unexpected pincer-type coordination (κ3-SBS) within a zerovalent platinum metallaboratrane complex. Dalton Transactions, 39 (1), 49-52. http://doi.org/10.1039/B917733G

Owen, G.R., Hugh Gould, P., Charmant, J.P.H., Hamilton, A., & Saithong, S. (2010). A new hybrid scorpionate ligand : a study of the metal–boron bond within metallaboratrane complexes. Dalton Transactions, 39 (2), 392-400. http://doi.org/10.1039/B911651F

Fanjul, T., Eastham, G., Fey, N., Hamilton, A., Orpen, A.G., Pringle, P.G., & Waugh, M. (2010). Palladium complexes of the Heterodiphosphineo-C6H4(CH2PtBu2)(CH2PPh2) are highly selective and robust catalysts for the Hydromethoxycarbonylation of Ethene. Organometallics, 29 (10), 2292-2305. http://doi.org/10.1021/om100049n

López-Gómez, M.J., Connelly, N.G., Haddow, M.F., Hamilton, A., & Orpen, A.G. (2010). Fluxional rhodium scorpionate complexes of the hydrotris(methimazolyl)borate (Tm) ligand and their static boratrane derivatives. Dalton Transactions, 39 (22), 5221-5230. http://doi.org/10.1039/C000651C

Tsoureas, N., Haddow, M.F., Hamilton, A., & Owen, G.R. (2009). A new family of metallaboratrane complexes based on 7-azaindole: B–H activation mediated by carbon monoxide. Chemical Communications, (18), 2538-2540. http://doi.org/10.1039/B822678D

Dyson, G., Hamilton, A., Mitchell, B., & Owen, G.R. (2009). A new family of flexible scorpionate ligands based on 2-mercaptopyridine. Dalton Transactions, (31), 6120. http://doi.org/10.1039/B905409J

Tsoureas, N., Bevis, T., Butts, C.P., Hamilton, A., & Owen, G.R. (2009). Further exploring the “Sting of the Scorpion” : hydride migration and subsequent rearrangement of Norbornadiene to Nortricyclyl on Rhodium(I). Organometallics, 28 (17), 5222-5232. http://doi.org/10.1021/om900499v

Blagg, R.J., Adams, C.J., Charmant, J.P.H., Connelly, N.G., Haddow, M.F., Hamilton, A., ... Ridgway, B.M. (2009). A novel route to rhodaboratranes [Rh(CO)(PR3){B(taz)3}]+via the redox activation of scorpionate complexes [RhLL′Tt]. Dalton Transactions, (40), 8724. http://doi.org/10.1039/B910108J

Carreira, M., Charernsuk, M., Eberhard, M., Fey, N., van Ginkel, R., Hamilton, A., ... Pringle, P.G. (2009). Anatomy of phobanes. diastereoselective synthesis of the three isomers of n-butylphobane and a comparison of their donor properties. Journal of the American Chemical Society, 131 (8), 3078-3092. http://doi.org/10.1021/ja808807s

Rudolf, G.C., Hamilton, A., Orpen, A.G., & Owen, G.R. (2009). A 'sting' on Grubbs' catalyst : an insight into hydride migration between boron and a transition metal. Chemical Communications, (5), 553-555. http://doi.org/10.1039/B816036H

Tsoureas, N., Owen, G.R., Hamilton, A., & Orpen, A.G. (2008). Flexible scorpionates for transfer hydrogenation : the first example of their catalytic application. Dalton Transactions, (43), 6039-6044. http://doi.org/10.1039/B809247H

Jones, T.W., Forrester, J.S., Hamilton, A., Rose, M.G., & Donne, S.W. (2007). Discharge rate capabilities of alkaline AgCuO2 electrode. Journal of Power Sources, 172 (2), 962-969. http://doi.org/10.1016/j.jpowsour.2007.05.032

Book chapters

Hamilton, A., & Whiteoak, C.J. (2021). Applied organometallics: Cp∗Co(iii)-catalysed C-H functionalisation as a maturing tool for the synthesis of heterocyclic compounds. In Organometallic Chemistry. (pp. 186-228). http://doi.org/10.1039/9781788017077-00186

Share this page

Cancel event

Are you sure you want to cancel your place on Saturday 12 November?