I am a Senior Lecturer in Biomedical Science here at SHU.
Study of functional polymorphisms in the family of 5-HT receptor genes. These polymorphisms may affect gene expression in certain groups of psychiatric patients and therefore affect their response to drug treatment. The current study is focussed on genotyping patients for the various polymorphisms, and relating the genotypes to mRNA and protein expression using real-time PCR, binding assays and reporter gene assays in mammalian cell lines.
This work is in collaboration with Dr Adrian Hall and is part of a long-standing association with Professor Gavin Reynolds of Queen's University, Belfast.
This work has focussed on the developed a cell culture model of CAG repeat diseases, which can be used to study the mechanisms of these disease, in particular the differences in vulnerability of affected neuronal cells to mitochondrial toxins. This has been applied to the investigation of the effect of polyunsaturated fatty acids and antioxidants on neurodegeneration in neuroblastoma cells.
Further studies are concentrating on investigating the potential neuroprotective effects of selenium. This work is in collaboration with Dr Philip Gardiner.
VEERASAKUL, Siriluk, WATIKTINKORN, Paritat, THANOI, Samur, DALTON, Caroline, FACHIM, Helene, NUDMAMUD-THANOI, Sutisa and REYNOLDS, Gavin (2017). Increased DNA methylation in the parvalbumin gene promoter is associated with methamphetamine dependence. Pharmacogenomics, 18 (14), 1317-1322.
ROCHA, Joel, PAXMAN, Jenny, DALTON, Caroline and BROOM, David (2016). Effects of a 12-week aerobic exercise intervention on eating behaviour, food cravings and 7-day energy intake and energy expenditure in inactive men. Journal of Sports Sciences, 34 (S1), s61-s61.
MASON, Rebecca, PASKINS, Aimee, DALTON, Caroline and SMITH, David (2016). Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation. Biochemistry, 55 (34), 4737-4741.
FACHIM, Helenne, SRISAWAT, Umarat, DALTON, Caroline, HARTE, Michael K, MARSH, Samuel, NEILL, Joanna C and REYNOLDS, Gavin (2016). Subchronic administration of phencyclidine produces hypermethylation in the parvalbumin gene promoter in rat brain. Epigenomics, 8 (9), 1179-1183.
ROCHA, Joel, PAXMAN, Jenny, DALTON, Caroline, WINTER, Edward and BROOM, David (2016). Effects of a 12-week aerobic exercise intervention on eating behaviour, food cravings and 7-day energy intake and energy expenditure in inactive men. Applied Physiology, Nutrition and Metabolism, 41 (11), 1129-1136.
ILLANGASEKERA, Yasitha A., KUMARASIRI, Ranjith P.V., FERNANDO, Devaka J. and DALTON, Caroline (2016). Association of FTO and near MC4R variants with obesity measures in urban and rural dwelling Sri Lankans. Obesity Research & Clinical Practice. (In Press)
ILLES-TOTH, Eva, RAMOS, Mafalda, CAPPAI, Roberto, DALTON, Caroline and SMITH, David (2015). Distinct higher-order alpha-synuclein oligomers induce intracellular aggretation. Biochemical Journal, 468 (3), 485-493.
ROCHA, Joel, PAXMAN, Jenny, DALTON, Caroline, WINTER, Edward and BROOM, David (2015). Effects of an acute bout of aerobic exercise on immediate and subsequent three-day food intake and energy expenditure in active and inactive pre-menopausal women taking oral contraceptives. Appetite, 89 (1), 183-191.
TANG, Hao, DALTON, Caroline, SRISAWAT, Umarat, ZHANG, Zhi Jun and REYNOLDS, Gavin (2014). Methylation at a transcription factor-binding site on the 5-HT1A receptor gene correlates with negative symptom treatment response in first episode schizophrenia. The International Journal of Neuropsychopharmacology, 17 (04), 645-649.
REYNOLDS, Gavin P., MCGOWAN, Olga O. and DALTON, Caroline F. (2014). Pharmacogenomics in psychiatry : the relevance of receptor and transporter polymorphisms. British Journal Of Clinical Pharmacology, 77 (4), 654-672.
SRISAWAT, Umarat, REYNOLDS, Gavin P., ZHANG, Zhi Jun, ZHANG, Xiang Rong, ARRANZ, Belen, SAN, Luis and DALTON, Caroline F. (2014). Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia. International Journal of Neuropsychopharmacology, 17 (3), 485-490.
ILLES-TOTH, Eva, DALTON, Caroline F. and SMITH, David (2013). Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States. Journal of The American Society for Mass Spectrometry, 24 (9), 1346-1354.
ROCHA, Joel, PAXMAN, Jenny, DALTON, Caroline, WINTER, Edward and BROOM, David (2013). Effects of an acute bout of aerobic exercise on immediate and subsequent three-day food intake and energy expenditure in active and inactive men. Appetite, 71, 369-378.
PRESHAW, PM, DE SILVA, N, MCCRACKEN, GI, FERNANDO, DJ, DALTON, Caroline, STEEN, ND and HEASMAN, PA (2010). Compromised periodontal status in an urgan Sri Lankan population with type 2 diabetes. Journal Of Clinical Periodontology, 37 (2), 165-171.
Hameida El Farssi - Effect of increased dietary protein on weight-loss, satiety and gastric emptying
- Nutrition and Obesity
- The Genetic and Lifestyle Factors Associated with Obesity
- Epigenetic Factors in Schizophrenia and its Treatment
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