Summary
I am Theme Lead for Living Well with Chronic Disease at the Advanced Wellbeing Research Centre, and lead the Health and Disease group in the Biomolecular Sciences Research Centre
-
Teaching
I teach Neurobiology, Applied Biochemistry, Immunology and Nutrition. I am part of the course leadership team for the Integrated Masters programme.
Biomedical Science
-
Research
My research interests include the investigation of the molecular mechanisms underlying differential responses to interventions to treat complex conditions such as schizophrenia, depression and obesity. Recent studies include laboratory-based experiments to investigate the effect of drugs at a cellular level, through to community-based projects analysing the individual variability in response to lifestyle interventions aimed at preventing weight-gain in patients taking antipsychotic drugs.
-
Publications
Journal articles
Loureiro, C.M., Fachim, H.A., Corsi-Zuelli, F., Shuhama, R., Joca, S., Menezes, P.R., ... Reynolds, G.P. (2020). Epigenetic-mediated N -methyl-D-aspartate receptor changes in the brain of isolated reared rats. Epigenomics. http://doi.org/10.2217/epi-2020-0151
Pennington, K., Klaus, K., Fachim, H.A., Butler, K., Trischel, K., Dalton, C., ... Reynolds, G.P. (2020). CACNA1C methylation: association with cortisol, perceived stress, rs1006737 and childhood trauma in males. Epigenomics, 12 (19), 1739-1749. http://doi.org/10.2217/epi-2020-0034
Fachim, H.A., Loureiro, C.M., Siddals, K., Dalton, C., Reynolds, G.P., Gibson, J.M., ... Heald, A.H. (2020). Circulating microRNA changes in patients with impaired glucose regulation. Adipocyte, 9 (1), 443-453. http://doi.org/10.1080/21623945.2020.1798632
Fachim, H.A., Siddals, K., Malipatil, N., Donn, R.P., Moreno, G.Y.C., Dalton, C., ... Heald, A.H. (2020). Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation. Adipocyte, 9 (1), 96-107. http://doi.org/10.1080/21623945.2020.1732513
Woodward, A., Broom, D., Dalton, C., Metwally, M., & Klonizakis, M. (2020). Supervised exercise training and increased physical activity to reduce cardiovascular disease risk in women with polycystic ovary syndrome: Study protocol for a randomized controlled feasibility trial. Trials, 21 (1), 101. http://doi.org/10.1186/s13063-019-3962-7
Illangasekera, Y.A., Kumarasiri, P.V.R., Fernando, D.J., & Dalton, C.F. (2020). Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans. BMC research notes, 13 (1), 34. http://doi.org/10.1186/s13104-020-4898-4
Fachim, H.A., Corsi-Zuelli, F., Loureiro, C.M., Iamjan, S.A., Shuhama, R., Joca, S., ... Reynolds, G.P. (2020). Early-life stress effects on BDNF DNA methylation in first-episode psychosis and in rats reared in isolation. Progress in Neuro-Psychopharmacology and Biological Psychiatry. http://doi.org/10.1016/j.pnpbp.2020.110188
Fachim, H., Corsi-Zuelli, F., Loureiro, C.M., Iamjan, S.A., Shuhama, R., Menezes, P.R., ... Reynolds, G. (2019). P.094 Early-life stress effects on BDNF DNA methylation in first episode psychosis and in rats reared in isolation. European Neuropsychopharmacology, 29 (6), S81-S82. http://doi.org/10.1016/j.euroneuro.2019.09.148
Klaus, K., Trischel, K., Fachim, H., Dalton, C., Reynolds, G., Heald, A., & Pennington, K. (2019). P.803 The effect of CACNA1C genotype on CACNA1C methylation and the association with cortisol release and perceived stress. European Neuropsychopharmacology, 29 (6), S536. http://doi.org/10.1016/j.euroneuro.2019.09.671
Loureiro, C., Fachim, H.A., Corsi-Zuelli, F., Menezes, P.R., Dalton, C., Del-Ben, C.M., ... Reynolds, G. (2019). P.071 Associations between genetic variants of NMDA receptor genes and first episode psychosis in a Brazilian sample. European Neuropsychopharmacology, 29 (6), S68. http://doi.org/10.1016/j.euroneuro.2019.09.131
Dalton, C., & Reynolds, G. (2019). Editorial: Pharmacogenomics and psychiatric disease. Neuroscience Letters, 726, 134602. http://doi.org/10.1016/j.neulet.2019.134602
Thaweethee, B., Suttajit, S., Thanoi, S., Dalton, C., Reynolds, G.P., & Nudmamud-Thanoi, S. (2019). Association of SLC1A2 and SLC17A7 polymorphisms with major depressive disorder in a Thai population. Asian Biomedicine, 12 (3), 131-138. http://doi.org/10.1515/abm-2019-0012
Hudspith, L., Shmam, F., Dalton, C.F., Princivalle, A., & Turega, S. (2019). Neurotransmitter selection by monoamine oxidase isoforms, dissected in terms of functional groups by mixed double mutant cycles. Organic & Biomolecular Chemistry. http://doi.org/10.1039/c9ob01558b
Thaweethee-Sukjai, B., Suttajit, S., Thanoi, S., Dalton, C., Reynolds, G., & Nudmamud-Thanoi, S. (2019). Parvalbumin Promoter Methylation Altered in Major Depressive Disorder. International journal of medical sciences, 16 (9), 1207-1214. http://doi.org/10.7150/ijms.36131
Woodward, A., Broom, D., Harrop, D., Lahart, I., Carter, A., Dalton, C., ... Klonizakis, M. (2019). The effects of physical exercise on cardiometabolic outcomes in women with polycystic ovary syndrome not taking the oral contraceptive pill: a systematic review and meta-analysis. Journal of Diabetes & Metabolic Disorders, 18 (2), 597-612. http://doi.org/10.1007/s40200-019-00425-y
Reynolds, G., Dalton, C., Watrimez, W., Jackson, J., & Harte, M.K. (2019). Adjunctive lurasidone suppresses food intake and weight gain associated with olanzapine administration in rats. Clinical Psychopharmacology and Neuroscience, 17 (2), 314-317. http://doi.org/10.9758/cpn.2019.17.2.314
Woodward, A., Klonizakis, M., Lahart, I., Carter, A., Dalton, C., Metwally, M., & Broom, D. (2019). The effects of exercise on cardiometabolic outcomes in women with polycystic ovary syndrome not taking the oral contraceptive pill: protocol for a systematic review and meta-analysis. Systematic Reviews, 8 (1). http://doi.org/10.1186/s13643-019-1030-8
Wei, X., Zhang, S., Yang, W., Luo, Z., Sun, P., Dalton, C., ... Reynolds, G.P. (2019). Neuromyelitis optica spectrum disorder in three generations of a Chinese family. Multiple Sclerosis and Related Disorders, 32, 94-96. http://doi.org/10.1016/j.msard.2019.04.010
Taylor-Whiteley, T.R., Le Maitre, C.L., Duce, J.A., Dalton, C.F., & Smith, D.P. (2019). Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model. Disease Models & Mechanisms, 12 (4). http://doi.org/10.1242/dmm.038042
Fachim, H.A., Loureiro, C.M., Corsi-Zuelli, F., Shuhama, R., Louzada-Junior, P., Menezes, P.R., ... Reynolds, G.P. (2019). GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function. Epigenomics, 11 (4), 401-410. http://doi.org/10.2217/epi-2018-0127
Abdella, H.M., El Farssi, H.O.E., Broom, D., Hadden, D., & Dalton, C. (2019). Eating behaviours and food cravings; influence of age, sex, BMI and FTO genotype. Nutrients, 11 (2), 377. http://doi.org/10.3390/nu11020377
Rocha, J., Paxman, J., Dalton, C., Hopkins, M., & Broom, D. (2018). An acute bout of cycling does not induce compensatory responses in pre-menopausal women not using hormonal contraceptives. Appetite, 128, 87-94. http://doi.org/10.1016/j.appet.2018.05.143
Fachim, H., Srisawat, U., Dalton, C., & Reynolds, G. (2018). Parvalbumin promoter hypermethylation in postmortem brain in schizophrenia. Epigenomics, 10 (5), 519-524. http://doi.org/10.2217/epi-2017-0159
Simper, T., Dalton, C., Broom, D., Ibrahim, W., Li, J., Bankole, C., & Chen, S. (2018). Greater glycaemic response to an oral glucose load in healthy, lean, active and young Chinese adults compared to matched Europeans. Nutrients, 10 (4), 487. http://doi.org/10.3390/nu10040487
Veerasakul, S., Watiktinkorn, P., Thanoi, S., Dalton, C., Fachim, H., Nudmamud-Thanoi, S., & Reynolds, G. (2017). Increased DNA methylation in the parvalbumin gene promoter is associated with methamphetamine dependence. Pharmacogenomics, 18 (14), 1317-1322. http://doi.org/10.2217/pgs-2016-0188
Mason, R., Paskins, A., Dalton, C., & Smith, D. (2016). Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation. Biochemistry, 55 (34), 4737-4741. http://doi.org/10.1021/acs.biochem.6b00708
Fachim, H., Srisawat, U., Dalton, C., Harte, M.K., Marsh, S., Neill, J.C., & Reynolds, G. (2016). Subchronic administration of phencyclidine produces hypermethylation in the parvalbumin gene promoter in rat brain. Epigenomics, 8 (9), 1179-1183. http://doi.org/10.2217/epi-2016-0050
Rocha, J., Paxman, J., Dalton, C., Winter, E., & Broom, D. (2016). Effects of a 12-week aerobic exercise intervention on eating behaviour, food cravings and 7-day energy intake and energy expenditure in inactive men. Applied Physiology, Nutrition and Metabolism, 41 (11), 1129-1136. http://doi.org/10.1139/apnm-2016-0189
Illangasekera, Y.A., Kumarasiri, R.P.V., Fernando, D.J., & Dalton, C. (2016). Association of FTO and near MC4R variants with obesity measures in urban and rural dwelling Sri Lankans. Obesity Research & Clinical Practice, 10 (Supp 1), S117-S124. http://doi.org/10.1016/j.orcp.2016.02.003
Illes-toth, E., Ramos, M., Cappai, R., Dalton, C., & Smith, D. (2015). Distinct higher-order alpha-synuclein oligomers induce intracellular aggretation. Biochemical Journal, 468 (3), 485-493. http://doi.org/10.1042/BJ20150159
Rocha, J., Paxman, J., Dalton, C., Winter, E., & Broom, D. (2015). Effects of an acute bout of aerobic exercise on immediate and subsequent three-day food intake and energy expenditure in active and inactive pre-menopausal women taking oral contraceptives. Appetite, 89 (1), 183-191. http://doi.org/10.1016/j.appet.2015.02.005
Reynolds, G.P., McGowan, O.O., & Dalton, C.F. (2014). Pharmacogenomics in psychiatry : the relevance of receptor and transporter polymorphisms. British Journal Of Clinical Pharmacology, 77 (4), 654-672. http://doi.org/10.1111/bcp.12312
Tang, H., Dalton, C., Srisawat, U., Zhang, Z.J., & Reynolds, G. (2014). Methylation at a transcription factor-binding site on the 5-HT1A receptor gene correlates with negative symptom treatment response in first episode schizophrenia. The International Journal of Neuropsychopharmacology, 17 (04), 645-649. http://doi.org/10.1017/S1461145713001442
Srisawat, U., Reynolds, G.P., Zhang, Z.J., Zhang, X.R., Arranz, B., San, L., & Dalton, C.F. (2014). Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia. International Journal of Neuropsychopharmacology, 17 (3), 485-490. http://doi.org/10.1017/S1461145713001375
Rocha, J., Paxman, J., Dalton, C., Winter, E., & Broom, D. (2013). Effects of an acute bout of aerobic exercise on immediate and subsequent three-day food intake and energy expenditure in active and inactive men. Appetite, 71, 369-378. http://doi.org/10.1016/j.appet.2013.09.009
Illes-Toth, E., Dalton, C.F., & Smith, D. (2013). Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States. Journal of The American Society for Mass Spectrometry, 24 (9), 1346-1354. http://doi.org/10.1007/s13361-013-0676-z
Preshaw, P.M., de Silva, N., McCracken, G.I., Fernando, D.J., Dalton, C., Steen, N.D., & Heasman, P.A. (2010). Compromised periodontal status in an urgan Sri Lankan population with type 2 diabetes. Journal Of Clinical Periodontology, 37 (2), 165-171. http://doi.org/10.1111/j.1600-051X.2009.01519.x
Taylor, D., Dalton, C., Hall, A., Woodroofe, M.N., & Gardiner, P. (2009). Recent developments in selenium research. British journal of biomedical science, 66 (2), 107-116. http://doi.org/10.1080/09674845.2009.11730256
Reynolds, L.M., Dalton, C.F., & Reynolds, G.P. (2001). Phospholipid fatty acids and neurotoxicity in human neuroblastoma SH-SY5Y cells. Neuroscience Letters, 309 (3), 193-196. http://doi.org/10.1016/S0304-3940(01)02071-7
Reynolds, G.P., Dalton, C.F., Tillery, C.L., Mangiarini, L., Davies, S.W., & Bates, G.P. (1999). Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation. Journal of Neurochemistry, 72 (4), 1773-1776. http://doi.org/10.1046/j.1471-4159.1999.721773.x
Laird, S.M., Dalton, C.F., Okon, M.A., Bunning, R.A.D., Marshall, R., & Li, T.C. (1999). Metalloproteinases and tissue inhibitor of metalloproteinase 1 (TIMP-1) in endometrial flushings from pre- and post-menopausal women and from women with endometrial adenocarcinoma. Journal of Reproduction and Fertility, 115 (2), 225-232. http://doi.org/10.1530/jrf.0.1150225
Li, T.C., Okon, M.A., Dalton, C.F., Heatley, M., & Laird, S.M. (1998). Is the measurement of placental protein-14 and CA-125 in plasma and uterine flushings useful in the evaluation of peri-menopausal and post-menopausal bleeding? Human Reproduction, 13 (10), 2895-2901. http://doi.org/10.1093/humrep/13.10.2895
Dalton, C.K., Laird, S.M., Estdale, S.E., Saravelos, H.G., & Li, T.C. (1998). Endometrial protein PP14 and CA-125 in recurrent miscarriage patients; Correlation with pregnancy outcome. Human Reproduction, 13 (11), 3197-3202. http://doi.org/10.1093/humrep/13.11.3197
Reynolds, G.P., & Dalton, C.F. (1998). Transgenic models and subcellular pathology - Do they tell us what goes wrong in Huntington's disease? Molecular Psychiatry, 3 (3), 192-195. http://doi.org/10.1038/sj.mp.4000374
Laird, S.M., Tuckerman, E.M., Dalton, C.F., Dunphy, B.C., Li, T.C., & Zhang, X. (1997). The production of leukaemia inhibitory factor by human endometrium: Presence in uterine flushings and production by cells in culture. Human Reproduction, 12 (3), 569-574. http://doi.org/10.1093/humrep/12.3.569
Dalton, C.F., Laird, S.M., Serle, E., Saravelos, H., Warren, M.A., Li, T.C., & Bolton, A.E. (1995). The measurement of CA 125 and placental protein 14 in uterine flushings in women with recurrent miscarriage; relation to endometrial morphology. Human Reproduction, 10 (10), 2680-2684. http://doi.org/10.1093/oxfordjournals.humrep.a135767
Li, T.C., Dalton, C., Hunjan, K.S., Warren, M.A., & Bolton, A.E. (1993). Implantation: The correlation of placental protein 14 concentrations in uterine flushing and endometrial morphology in the peri-implantation period. Human Reproduction, 8 (11), 1923-1927. http://doi.org/10.1093/oxfordjournals.humrep.a137961
Mackenna, A., Li, T.C., Dalton, C., Bolton, A., & Cooke, I. (1993). Placental protein 14 levels in uterine flushing and plasma of women with unexplained infertility. Fertility and Sterility, 59 (3), 577-582. http://doi.org/10.1016/S0015-0282(16)55803-8
Li, T.C., Dalton, C., Bolton, A.E., & Cooke, I.D. (1993). Concentration of endometrial protein PP14 in uterine flushings throughout the menstrual cycle in normal, fertile women. BJOG: An International Journal of Obstetrics & Gynaecology, 100 (5), 460-464. http://doi.org/10.1111/j.1471-0528.1993.tb15272.x
Li, T.C., Dalton, C., Bolton, A.E., Ling, E., Warren, A., & Cooke, I.D. (1992). An analysis of the variation of plasma concentrations of placental protein 14 in artificial cycles. Fertility and Sterility, 57 (4), 776-782. http://doi.org/10.1016/S0015-0282(16)54958-9
Conference papers
Fachim, H.A., Siddals, K., Malipatil, N., Donn, R., Dalton, C., Gibson, M., & Heald, A. (2019). Weight loss in people with impaired glucose regulation affects caveolin-1 (CAV1) expression and DNA methylation in a tissue-specific way. Diabetologia, 62, S138. http://doi.org/10.1007/s00125-019-4946-6
Fachim, H., Loureiro, C., Corsi-Zueli, F., Menezes, P.R., Louzada Jr, P., Dalton, C., ... Reynolds, G. (2018). S14. DNA methylation changes in GABAergic and glutamatergic markers in early schizophrenia. Schizophrenia Bulletin, 44 (suppl_), S329. http://doi.org/10.1093/schbul/sby018.801
Whiteley, T., Dalton, C., Duce, J., Maitre, C.L., & Smith, D. (2017). Establishing a three-dimensional human neural cell culture model of Parkinson's disease. JOURNAL OF NEUROCHEMISTRY, 142, 111-112.
Rocha, J., Paxman, J., Dalton, C., & Broom, D. (2016). Effects of a 12-week aerobic exercise intervention on eating behaviour, food cravings and 7-day energy intake and energy expenditure in inactive men. Journal of Sports Sciences, 34 (S1), s61. http://doi.org/10.1080/02640414.2016.1260807
Paskins, A.R., Dalton, C.F., Duckett, C.J., & Smith, D.P. (2016). INVESTIGATING METAL BINDING AND THE RESULTING CONFORMATIONAL CHANGES AND AGGREGATION OF MONOMERIC WILD-TYPE ALPHA-SYNUCLEIN AND A PHOSPHORYLATION MIMIC. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36, 594-595.
Fachim, H., Srisawat, U., Harte, M.K., Dalton, C.F., & Reynolds, G.P. (2014). DNA methylation alterations in GABAergic system in subchronic PCP rat model. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 24, S164. http://doi.org/10.1016/S0924-977X(14)70249-4
Reynolds, G., Dalton, C., & Tang, H. (2014). DNA METHYLATION OF THE 5-HT1A RECEPTOR GENE PROMOTER IS ASSOCIATED WITH NEGATIVE SYMPTOM RESPONSE TO ANTIPSYCHOTIC DRUG TREATMENT. SCHIZOPHRENIA RESEARCH, 153, S251-S252.
Fachim, H.A., Srisawat, U., Harte, M.K., Dalton, C., & Reynolds, G. (2014). DNA METHYLATION AND GABAERGIC PATHOLOGY OF SCHIZOPHRENIA. SCHIZOPHRENIA RESEARCH, 153, S314.
Fachim, H.A., Srisawat, U., Harte, M., Reynolds, G., & Dalton, C. (2014). DNA METHYLATION AND GABAERGIC PATHOLOGY OF SCHIZOPHRENIA. SCHIZOPHRENIA RESEARCH, 153, S92.
Bokhamada, H.K., Woodroofe, M.N., Jones, T.H., Small, S.H., Kay, W., & Dalton, C.F. (2013). INVESTIGATION OF THE EFFECT OF TESTOSTERONE TREATMENT ON THE EXPRESSION OF CHEMOKINE RECEPTORS IN MONOCYTE/MACROPHAGE THP-1 CELL LINE. ATHEROSCLEROSIS, 231 (2), E6. http://doi.org/10.1016/j.atherosclerosis.2013.07.024
Stanley, K.N., Cabry, S.H., Dalton, C.F., & Jordan-Mahy, N. (2007). Use of mucin-overproducing cell line HT29-MTX to study the interaction between Campylobacter jejuni and commensal micro-organisms at the mucin interface of the gastrointestinal tract. ZOONOSES AND PUBLIC HEALTH, 54, 102.
Theses / Dissertations
Srisawat, U. (2015). Genetic polymorphisms, DNA methylation and antipsychotic induced weight gain in schizophrenia patients. (Doctoral thesis). Supervised by Dalton, C.
Bokhamada, H. (2014). The effect of testosterone on factors associated with diabetes, atherosclerosis and obesity. (Doctoral thesis). Supervised by Dalton, C., Woodroofe, N., & Jones, H.
Illes-Toth, T.E. (2013). Linking the structure of alpha-synuclein oligmers to function in Parkinson's disease. (Doctoral thesis). Supervised by Smith, D., & Dalton, C.
Rocha, J.B.P.F.D. (2013). Effects of exercise on hunger, food intake and energy expenditure. (Doctoral thesis). Supervised by Broom, D., Paxman, J., & Dalton, C.
Ben-Hasan, M.H.A. (2011). Characterisation of the potentially diverse transcriptional regulatory mechanisms of human coagulation PZ gene. (Doctoral thesis). Supervised by Hall, A., Winship, P., & Dalton, C.
De Silva, S.N.T. (2009). Type 2 diabetes in Sri Lanka : Genetic epidemiology and periodontal association. (Doctoral thesis). Supervised by Fernando, D.J.S., Heasman, P., Preshaw, P., & Dalton, C.
Bunn, L.J. (2008). 5-HT1A receptor expression : Studies in postmortem tissue and characterisation of a model system. (Doctoral thesis). Supervised by Dalton, C., Hall, A., & Reynolds, G.
-
Other activities
I am Associate Editor for Neuroscience Letters
-
Postgraduate supervision
Hameida El Farssi - Effect of increased dietary protein on weight-loss, satiety and gastric emptying
- Nutrition and Obesity
- The Genetic and Lifestyle Factors Associated with Obesity
- Epigenetic Factors in Schizophrenia and its Treatment