Daniel obtained a BSc with honours in Human Biology and Psychology from Aston University, including a year placement at Unilever R&D where he investigated biomarkers of stress and heart health/lifestyle interventions in a clinical study. Following his degree he undertook a PhD at Sheffield Hallam University investigating the effects of testosterone on atherosclerosis before moving to the University of Sheffield to continue this research as a postdoc. Focus shifted towards testosterone’s tissue-specific metabolic actions and how these relate to cardiovascular risk and type-2 diabetes in males using cell culture systems, pre-clinical models and medical trials of testosterone replacement. Daniel moved to Sheffield Hallam in 2016 as a lecturer in Biochemistry.
Daniel is a lecturer in Biochemistry with research interests in cardiovascular disease, type-2 diabetes, obesity and the role of testosterone in these diseases. Daniel's current research focuses on testosterone’s tissue-specific metabolic actions and how these relate to cardiovascular risk and type-2 diabetes in males using cell culture systems, pre-clinical models and medical trials of testosterone replacement. This research extends through ongoing collaborations with partners at the University of Sheffield, University of Chile, Barnsley NHS Foundation Trust and Bayer Healthcare. His research is published in top endocrine peer-reviewed journals as critical reviews and he presented at international conferences. His research has featured on BBC News Health and he further won the Kroto Research Inspiration 2016 award at the University of Sheffield.
Daniel is a Fellow of the Higher Education Academy. His teaching areas relate to his research interests and include metabolism, immunology, cell biology and biological basis of disease.
Daniel is a Fellow of the Higher Education Academy. He teaches in the general area of Biochemistry with a particular focus on metabolism. This expands into other key areas related to physiology, nutrition and human biology. He is deputy course leader for the Biomedical Sciences undergraduate degree.
Testosterone in health and disease
Testosterone is no longer a hormone limited to reproductive/sexual medicine but is rather a multi-system player with much wider range of actions. Epidemiological studies draw clear associations between low testosterone in men and metabolic disorders such as, type-2 diabetes, obesity and cardiovascular risk to the extent that low testosterone is now considered an independent risk factor for heart disease. The majority of testosterone replacement trials do indeed demonstrate beneficial effects on men’s health, however, the detailed mechanisms of how testosterone may offer this protection is not fully known. Daniel's research continues to investigate the tissue-specific actions of testosterone related to the pathogenesis of type-2 diabetes and cardiovascular disease to try and harness the therapeutic potential of this hormone.
Developing an in vitro artery model for investigating diabetic atherosclerosis.
In vitro human cell models are valuable research tools for exploration of novel mechanisms in atherogenesis, but are most commonly limited to 2D single-cell culture. While endothelial dysfunction is recognised as an initial step in the atherosclerotic process that is well advanced in diabetes, the pathogenesis of atherosclerosis involves multiple vascular and immune cell interactions; primarily endothelial cells (EC) and smooth muscle cells (SMC) as well as blood borne inflammatory cells such as monocyte-derived macrophages. 2D single cell cultures do not account for the complexity of the native artery environment with physiological pulsatile flow conditions and don’t allow study of interactions between various cell types and/or the extracellular matrix. Daniel's research interests are involved in providing an applicable 3D in vitro co-culture vascular model that could accelerate advances in the field allowing for novel mechanisms to be investigated. This research is supported by the Society for Endocrinology.
Jones, T.H., & Kelly, D. (2018). Randomized controlled trials - mechanistic studies of testosterone and the cardiovascular system. Asian journal of andrology, 20 (2), 120-130. http://doi.org/10.4103/aja.aja_6_18
Kelly, D., Akhtar, S., Sellers, D., Muraleedharan, V., Channer, K.S., & Jones, T.H. (2016). Testosterone differentially regulates targets of lipid and glucose metabolism in liver, muscle and adipose tissues of the testicular feminised mouse. Endocrine, 54 (2), 504-515. http://doi.org/10.1007/s12020-016-1019-1
Invited reviewer of original manuscripts for several journals in the endocrine and life sciences field.
External examiner (MPhil), University of Sheffield, 2017.
Honorary Lectureship, University of Sheffield, awarded in 2016.
Lauren Bateman - "The anti-inflammatory effects of testosterone on atherosclerosis" (Sep 2016 - Sep 2020)
Robert Tempest - "Colon-derived extracellular vesicles and their impact on adipose cells" (Sep 2017 - Sep 2021)