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Dr Gail Haddock BSc, PhD, FHEA

Senior Lecturer


Summary

I was appointed as a lecturer at Sheffield Hallam University after completing a PhD, followed by a 5-year postdoctoral position in neuroscience at Sheffield Hallam University. I teach a wide range of subjects including anatomy and physiology, cell biology and biochemistry. My main research area is neuroimmunology with a specific interest in multiple sclerosis.

About

I was appointed initially at Sheffield Hallam University as a research technician, during which time I studied for a PhD part time. I then worked as a postdoctoral researcher for 5 years. My work was investigating the role of the ADAMTSs in multiple sclerosis from which I published several research papers and presented my work at national and international conferences. I was then appointed a lecturer at Sheffield Hallam University.

Cell Biology/Biochemistry
Neuroscience

Teaching

Cells and molecules, organs and systems, biomedical investigative techniques, biology of disease, PSP 2 and undergraduate and postgraduate projects

Research

Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the central nervous system (CNS) affecting mainly white matter. Key events in the pathogenesis of MS include breakdown of the blood-brain barrier, resulting in infiltration of inflammatory cells leading (directly or indirectly) to changes in the composition of the ECM. The extracellular matrix proteins are important to brain structure through maintenance of the correct hydrodynamics and in their interactions with other ECM components.The sequence of events leading to changes in the ECM of white matter in MS are not known, nor are the enzymes that are responsible for these processes which ultimately lead to axonal loss. Alterations in turnover of the ECM contribute to disease processes and are modulated by injury. ADAMTS-1, -4 and -5 have been shown to cleave aggregating chondroitin sulphate proteoglycans (CSPGs) such as aggrecan, versican and brevican which are key components of CNS ECM. We wish to investigate the roles played in this process by the ADAMTS group.

Collaborators: 

Dr Stuart Allen, University of Manchester
Dr David Buttle, University of Sheffield

Publications

Journal articles

Lawton, M., Haddock, G., Conroy, P., & Sage, K. (2016). Therapeutic alliances in stroke rehabilitation: a meta-ethnography. Archives of Physical Medicine and Rehabilitation, 97 (11), 1979-1993. http://doi.org/10.1016/j.apmr.2016.03.031

Phillips, K.L.E., Cullen, K., Chiverton, N., Michael, A.L.R., Cole, A.A., Breakwell, L.M., ... Le Maitre, C.L. (2015). Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes. Osteoarthritis and Cartilage, 23 (7), 1165-1177. http://doi.org/10.1016/j.joca.2015.02.017

Bradford, C.M., Ramos, I., Cross, A.K., Haddock, G., McQuaid, S., Nicholas, A.P., & Woodroofe, M.N. (2014). Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis. Journal of Neuroimmunology, 273 (1-2), 85-95. http://doi.org/10.1016/j.jneuroim.2014.05.007

Wang, J., Tian, Y., Phillips, K.L.E., Chiverton, N., Haddock, G., Bunning, R., ... Risbud, M.V. (2013). Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. Arthritis & rheumatism, 65 (3), 832-842. http://doi.org/10.1002/art.37819

Phillips, K.L.E., Chiverton, N., Michael, A.L.R., Cole, A.A., Breakwell, L.M., Haddock, G., ... Le Maitre, C.L. (2013). The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc. Arthritis research & therapy, 15 (6), R213. http://doi.org/10.1186/ar4408

Hadjivassiliou, M., Aeschlimann, P., Sanders, D.S., Mäki, M., Kaukinen, K., Grünewald, R.A., ... Aeschlimann, D.P. (2013). Transglutaminase 6 antibodies in the diagnosis of gluten ataxia. Neurology, 80 (19), 1740-1745. http://doi.org/10.1212/WNL.0b013e3182919070

Frentzou, G., Bradford, C., Harkness, K.A., Haddock, G., Woodroofe, N.W., & Cross, A. (2012). IL-1β Down-Regulates ADAMTS-13 mRNA Expression in Cells of the Central Nervous System. Journal of Molecular Neuroscience, 46 (2), 343-351. http://doi.org/10.1007/s12031-011-9591-6

Bradford, C.M., Cross, A., Haddock, G., Woodroofe, N.W., & Sharrack, B. (2011). Citrullination of CNS proteins in the pathogenesis of multiple sclerosis. Future Neurology, 6 (4), 521-530. http://doi.org/10.2217/fnl.11.30

Reid, M.J., Cross, A.K., Haddock, G., Allan, S.M., Stock, C.J., Woodroofe, M.N., ... Bunning, R.A.D. (2009). ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat. Neuroscience letters, 452 (3), 252-257. http://doi.org/10.1016/j.neulet.2009.01.058

Bradford, C.M., Cross, A.K., Haddock, G., & Woodroofe, M.N. (2009). Citrullination in MS: potential for a new diagnostic test. British journal of neuroscience nursing, 5 (1), 1-13. http://www.bjnn.co.uk/cgi-bin/go.pl/library/abstract.html?uid=37804

Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J.T., Bunning, R.A., ... Woodroofe, M.N. (2007). Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat. Biochemical Society Transactions, 35 (4), 692. http://doi.org/10.1042/BST0350692

Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A., ... Woodroofe, N. (2006). ADAMTS -1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. Brain research, 1088 (1), 19-30. http://doi.org/10.1016/j.brainres.2006.02.136

Cross, A.K., Haddock, G., Surr, J., Plumb, J., Buttle, D.J., & Woodroofe, N. (2005). Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis. Journal of autoimmunity, 26 (1), 16-23. http://doi.org/10.1016/j.jaut.2005.09.026

Haddock, G., Cross, A.K., Plumb, J., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2005). Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter. Multiple Sclerosis, 12 (4), 386-396. http://doi.org/10.1191/135248506ms1300oa

Plumb, J., McQuaid, S., Cross, A.K., Surr, J., Haddock, G., Bunning, R.A.D., & Woodroofe, M.N. (2005). Upregulation of ADAM-17 expression in active lesions in multiple sclerosis. Multiple Sclerosis, 12 (4), 375-385. http://doi.org/10.1191/135248506ms1276oa

Plumb, J., Cross, A.K., Surr, J., Haddock, G., Smith, T., Bunning, R.A.D., & Woodroofe, M.N. (2005). ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 164 (1-2), 1-9. http://doi.org/10.1016/j.jneuroim.2005.02.021

Conference papers

Abuneeza, E., Cross, A., Haddock, G., Bunning, R., & Woodroofe, N. (2014). Expression of ADAMTS-9 in the central nervous system in multiple sclerosis and its relationship to cleavage of aggrecan and versican. Journal of Neuroimmunology, 275 (1-2), 131-132. http://doi.org/10.1016/j.jneuroim.2014.08.353

Abuneeza, E., Bunning, R., Cross, A., Haddock, G., & Woodroofe, N. (2013). Changes in extracellular matrix chondroitin sulphate proteoglycans in multiple sclerosis white matter lesions: a role for ADAMTS-9. IMMUNOLOGY, 140, 128.

Gibrel, G., Bunning, R., Cross, A., Haddock, G., & Buttle, D. (2012). ADAMTSs and extracellular matrix alteration in multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, 253 (1-2), 97.

Phillips, K.L.E., Chiverton, N., Cole, A., Michael, A., Breakwell, L., Haddock, G., ... Le Maitre, C.L. (2012). Interleukin-1 Regulates Chemokine Expression in the Human Intervertebral Disc. JOURNAL OF PATHOLOGY, 228, S30.

Phillips, K.L.E., Chiverton, N., Cole, A., Michael, A., Breakwell, L., Haddock, G., ... Le Maitre, C.L. (2012). Chemokines and their Receptors in the Human Intervertebral Disc. JOURNAL OF PATHOLOGY, 228, S30.

Gibrel, G., Cross, A.K., Haddock, G., Buttle, D.J., & Bunning, R.A.D. (2012). The role of ADAMTSs and versican cleavage in multiple sclerosis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 93 (4), A11.

Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J., Bunning, R.A.D., ... Woodroofe, M.N. (2007). Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat. Biochemical Society Transactions, 35 (4), 692-694. http://doi.org/10.1042/BST0350692

Haddock, G., Cross, A.K., Bunning, R.A.D., Plumb, J., Surr, J., Buttle, D.J., ... Woodroofe, M.N. (2004). Expression of ADAMTS-1, -4 -5 and TIMP-3 in different stages of experimental autoimmune encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 58.

Plumb, J., Bunning, R., Cross, A., Surr, J., Haddock, G., Smith, T., & Woodroofe, N. (2004). ADAM-17 expression in spinal cord white matter of Lewis rats with EAE. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 116.

Cross, A., Haddock, G., Surr, J., Bunning, R.A.D., Buttle, D., Romero, J., & Woodroofe, N.M. (2004). Expression of ADANITS-1, 4, -5 and TIMP-3 in a primary human astrocyte cell line: possible role in CNS physiology and pathology. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 121.

Haddock, G., Cross, A.K., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2003). Expression of ADAMTS-1,-4-5 and TIMP-3 in central nervous system cell lines: Possible role in CNS physiology and pathology. GLIA, 33.

Theses / Dissertations

Liaskos, M. (2016). The role of the urothelial mucosa in bladder mechanosensation. (Doctoral thesis). Supervised by Mckay, N., Lawson, K., & Haddock, G.

Abuneeza, E. (2015). Changes in chondroitin sulphate proteoglycan in multiple sclerosis : A role for ADAMTS-9. (Doctoral thesis). Supervised by Woodroofe, N., Bunning, R., Cross, A., & Haddock, G.

Phillips, K. (2013). Cytokines and chemokines in the pathogenesis of low back pain. (Doctoral thesis). Supervised by Le Maitre, C., Cross, A., Bunning, R., & Haddock, G.

Gibrel, G.G.F. (2012). The role of ADAMTS-1, -4 and -5 in multiple sclerosis. (Doctoral thesis). Supervised by Bunning, R., Cross, A., Haddock, G., & Buttle, D.

Postgraduate supervision

The Role Of ADAMTS-1, 4 and 9 in Multiple Sclerosis (MS)
The Role of the Urothelial Mucosa In Bladder Mechanosensation

Investigating the role of citrullination, a post translational modification, of CNS proteins on the disease pathogenesis and whether antibodies in the serum and/or cerebrospinal fluid may provide a diagnostic indicator of multiple sclerosis.

The role of ADAMTS-1, -4 and -5 in multiple sclerosis

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