Dr Jillian Newton
Research Fellow, Contract Research and Consultancy Lead
Summary
My principle background is in MALDI-MS initially proteomics before moving onto MALDI-MS imaging. I have experience in MALDI, DESI and ICP imaging techniques as well associated techniques and software.
About
I work within the Biomolecular Sciences Research Centre as a contract researcher, working with industry, external and internal university researchers, NHS trusts and charities etc. creating bespoke projects that help to solve scientific questions. My principal research interest area is all things mass spectrometry in particular imaging modalities and how these can link together to provide multimodal data that in turn will help create a bigger picture which works well with my involvement as co-lead of the Sheffield Multimodal Imaging Centre (SMIC).
Teaching
College of Health, Wellbeing and Life Sciences
Contract Research and Consultancy
Mass Spectrometry Training
Research
- Biomolecular Sciences Research Centre
- Industry and Innovation Research Institute
Colgate-Palmolive study of the skin microbiome and its effect on Atopic Dermatitis
Utilising MALDI-MSI to investigate Urothelial cancer of the bladder and treatments (INVEST)
Colgate-Palmolive, Reckitt Benckiser, Roche, Cancer Research, Sheffield Teaching Hospital, Leeds University, Sheffield University, Australian National University, UCL, UKRI, BBSRC
Publications
Journal articles
Ali, A.N., Su, L., Newton, J., Grayson, A.K., Taggart, D., Bell, S.M., ... Majid, A. (2025). Dietary Carnosine Supplementation in Healthy Human Volunteers: A Safety, Tolerability, Plasma and Brain Concentration Study. Nutrients, 17 (13). http://doi.org/10.3390/nu17132130
Angelini, R., Yutuc, E., Wyatt, M.F., Newton, J., Yusuf, F.A., Griffiths, L., ... Griffiths, W.J. (2021). Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging. Analytical Chemistry. http://doi.org/10.1021/acs.analchem.0c05399
Couto, N., Newton, J.R.A., Russo, C., Karunakaran, E., Achour, B., Al-Majdoub, Z.M., ... Barber, J. (2021). Label-free Quantitative Proteomics and Substrate Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in ex Vivo Human Skin and a Human Living Skin Equivalent Model. Drug Metabolism and Disposition. http://doi.org/10.1124/dmd.120.000168
Yutuc, E., Angelini, R., Baumert, M., Mast, N., Pikuleva, I., Newton, J., ... Griffiths, W.J. (2020). Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism. Proceedings of the National Academy of Sciences, 201917421. http://doi.org/10.1073/pnas.1917421117
Mahmoud, K., Cole, L., Newton, J., Mohamed, S., Al-Enazi, M., Qirke, P., & Clench, M. (2013). Detection of the epidermal growth factor receptor, amphiregulin and epiregulin in formalin-fixed paraffin-embedded human placenta tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging. European Journal of Mass Spectrometry, 19 (1), 17-28. http://doi.org/10.1255/ejms.1212
Gaetano, C., Harris, S., Craze, M., Newton, J., Fisher, M., Shima, D.T., ... Kanthou, C. (2012). Do anti-angiogenic VEGF (VEGFxxxb) isoforms exist? : a cautionary tale. PLoS ONE, 7 (5), e35231. http://doi.org/10.1371/journal.pone.0035231
Eboigbodin, K.E., Newton, J.R.A., Routh, A.F., & Biggs, C.A. (2006). Bacterial quorum sensing and cell surface electrokinetic properties. Applied Microbiology and Biotechnology, 73 (3), 669-675. http://doi.org/10.1007/s00253-006-0505-4
Newton, J., Parkinson, D., & Clench, M. (2006). Strategies for examination of Alzheimer’s disease amyloid precursor protein isoforms. .
Eboigbodin, K.E., Newton, J.R.A., Routh, A.F., & Biggs, C.A. (2005). Role of nonadsorbing polymers in bacterial aggregation. Langmuir, 21 (26), 12315-12319. http://doi.org/10.1021/la051740u
Burley, I., Bilic, B., Hewson, A.T., & Newton, J.R.A. (2001). ChemInform Abstract: A Versatile Approach to 3‐Alkyl and 2,3‐Dialkylpyrroles. ChemInform, 32 (9). http://doi.org/10.1002/chin.200109113
Burley, I., Bilic, B., Hewson, A.T., & Newton, J.R.A. (2000). A versatile approach to 3-alkyl and 2,3-dialkylpyrroles. Tetrahedron Letters, 41 (46), 8969-8972. http://doi.org/10.1016/S0040-4039(00)01591-4
Other activities
British Mass Spectrometry Society, Co-lead (Symposium Lead organiser BMSS-SIG in MS Imaging
Drug Metabolism and Discussion Group, Session Organiser
Postgraduate supervision
MSc and MRes students