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Dr Khaled Khatab CStat, CSci RSS

Reader in Medical Statistics and Health Economic modelling

Summary

Khaled has been working at Sheffield Hallam University (SHU) since 2012, initially as a Principal Research Fellow and later as a Reader (equivalent to Associate Professor) in Medical Statistics and Health Economic Modelling.

Due to the seniority of his current post, Khaled performs many duties and roles such as leading on and contributing to multidisciplinary research teams as well as leading on the statistics and health economic components of funded research projects and bids.

  • About

    Since March 2015, Khaled has taken over Professor Malcolm Whitfield's research project commitments, including leading PhD research projects as well as his major statistical modelling project. This includes his Health Economics leadership role, working across diverse disciplines within the Faculty of Health and Wellbeing.

    Khaled currently leads on statistical modelling in various projects, undertaking methodological and applied research and consultancy, using mathematical and statistical techniques in health and healthcare.

    Since early 2017, Khaled is Chair and of the Child Health and Epidemiology Group and line manager to the members of the Group. The aim of this theme is to develop and deploy new and improved evidence on the causes and determinants of neonatal and child & maternal morbidity and mortality, on intervention handling and on the effectiveness of interventions to enlighten and impact the research priorities in this area both nationally and internationally. This includes estimating specific distribution of the main causes of under-5 deaths, as well as maternal death and of the proportion of these deaths which can be prevented and lives saved through developing precise interventions and enhancing modelling methodology along with new predictions of efficacy and effectiveness of child survival interventions.

    From 2015-2017, Khaled was Chair of the Research Methodology Team. The aim of this Research Team is to promote research design, methodologies and statistical modelling in the University. To support science of quality in all of our projects, the Centre invested in a Research Methods Group. The Group ensures that all research projects, bids and contracts are driven by clear conceptual frameworks, consisting of problem definitions, literature review, hypothesis, research questions, recruitment procedure, data collections, statistical methods and health economic modelling. They are implemented with well-documented research designs and methods, using appropriate statistical analysis.

    Khaled has been appointed as a Visiting Professor in Statistics by the University of Ohio Zanesville, USA for 2016-2018.  During this period, he has been working on a joint project with Ohio to assess the efficiency and effectiveness of herbal vs. orthodox medicines in the USA publication: 'A case study for Campus students from different age groups'. Also, he taught the MATH 2500 (Statistics) course during the spring semester of 2017.

    In early 2017, Khaled became an academic Editor for PLOSE ONE Journal.

    Khaled was recently nominated as an inspirational research supervisor, which is a significant achievement and is testament to the quality of his professional practice. It reflects well on his professionalism and his support to the PhD students. 

    Khaled has over 17 years' professional and/or post-doctoral experience in medical statistics and health economic modelling applied to epidemiology, social care, and public health. Over this period, in his role as Principal Investigator or Co-Investigator, he has secured over £4.5 (£1.2 million at SHU since 2012) million of research and consultancy grants for different institutions and published over 30 articles (H index 23) (20 as first author), with an average impact factor of 4 across all publications in high-impact internationally peer-reviewed journals such as the American Journal of Tropical Medicine, PLOS ONE and Nature (at least eight articles were considered in REF 2014 and REF 2020). 

    During the period 2016-2018, Khaled was able to develop a couple of novel models. He assessed the area-specific spatial effects and risk factors of co-morbidity in children under 5 using a Bayesian Multinomial geoadditive model (published in PLOS ONE in July, 2016). Khaled's other model is focused on understanding what drove toxic chemical release across a 16-year period between 1998 and 2013in the USA, using an input-output structural decomposition analysis combining US economic, population and National Toxics Release Inventory datasets (published in Nature, November, 2016). Recently, Khaled assessed the area-specific spatial effects and associate Risk Factors with Child Welfare, including Child Labour and Violence against Child issues in Egypt, using Bayesian Geospatial Modelling with Multiple Imputation. This model is novel in this area of research and this paper was recently accepted by PLOS ONE (in 2018).

    Khaled's main research interests are in Bayesian statistical methods and their application to epidemiology and health, in particular, addressing maternal and child health and a variety of health-related health inequalities, both in the developing countries and command economies, using large scale household data. This includes Bayesian modelling and diseases mapping, statistical methods applied to epidemiology, survival analysis, longitudinal data analysis, meta-analysis and Bayesian spatial Analysis.

    Contribution to the development of statistics field: During these years, Khaled developed an advanced statistical technique utilising highly sophisticated models to enable us to accommodate a large number of variables, such as categorical, metrical, binary, and spatial, as well as numerous types of outcome variables. Khaled has developed and used the Markov Chain Mont Carlo (MCMC) package in R software and a C++ code compiler system to develop this model, which has since been used widely. The outputs of this model system were published in the American Journal of Tropical Medicine.

    These articles have had a significant impact on statistical methods in medical research. These research papers presented both theoretical contributions and empirical applications of advanced statistical techniques including: Geo-additive Latent Variable Models which link individual measures with area variables to account for spatial correlation; multilevel models that address the issue of clustering within the family and household; multi-process models that account for interdependencies over life-course events and non-random utilisation of health services; flexible parametric alternatives to existing intensity models. These techniques are illustrated mainly through modelling in maternal and child health contexts, using data from different sources.

    Khaled has also produced conference papers, submitted abstracts, written two chapters in books as well as one entire book and delivered oral presentations, invited presentations as well as performing the role of Chair at over 20 national and international conferences.

    In Khaled previous roles, he worked as an Assistant Professor in Medical Statistics and Statistical Methods in Epidemiology for the RWTH Aachen University in Germany. In this capacity, he led the Epidemiology and Public Health Scheme at the Medical School of Aachen for five years from 2008 to 2012. His primary role was to direct and contribute to the output of multidisciplinary research teams (which comprised medical doctors, statisticians, a data manager, a sociologist and various research assistants). Khaled led the statistics and health economic components of funded research projects and bids. Another of Khaled's principal duties was to mentor, advise and train junior researchers in order to improve their skills and adjust their strategies to meet essential criteria, thereby conforming to the overall strategy of the University. As Principal Investigator (PI), he led several projects, collaborating with Aachen University, Warwick University, and Stockholm University.  Data from these projects has been published in a number of prestigious international journals.

    Khaled worked as a statistical consultant at Glasgow University from 2007 to 2008 and participated in a project funded by Glasgow City Council and the Scottish Government. The aim of this project was primarily to evaluate the impact of the provision of new social housing on physical and mental health.  It focused upon a longitudinal assessment of the health-related effects of major housing improvements across Scotland. There was no marked change in physical health outcomes for people who were rehoused, nor was there any significant change in health-related behaviours.

    From 2000 to 2008, Khaled worked as a researcher (and later as a senior researcher) in the Institute of Statistics at Munich University, where he gained both his MSc and PhD qualifications. During this period, Khaled taught statistics and supervised undergraduate and postgraduate students whilst developing modules and teaching materials.

    Khaled also served as PI and participated (COI) in various projects which focused upon maternal and child health in developing countries in collaboration with Heidelberg University.

    Khaled has been developing and applying modelling in support of healthcare decision-making, nationally and internationally, across a large range of diseases, interventions and service planning and policy issues, over the past 17 years. He has delivered many projects over a diverse range of research studies, including maternal and child health, CVD disease in the UK and abroad, dementia patients in the UK and abroad, public health problems in Europe and developing countries and cancer projects.  This experience has led him to become a consultant for statistics and quantitative methods at the Royal Statistical Society in London.

    Advanced Statistics, Health Economic modelling, methodology and application of decision-analytic modelling and Bayesian approaches to Health Technology Assessment

  • Teaching

    Department of Nursing and Midwifery

    Health And Wellbeing

    Statistics III (Bayesian Inference, Multivariate Analysis, Probability Analysis, Regression Analysis)
    Statistics I and II (introductory courses in statistics)
    Medical Statistics
    Advanced Statistical Methods in Epidemiology

  • Research

    • Centre for Health and Social Care Research

    Khaled has over 17 years' professional and/or post-doctoral experience in medical statistics and health economics modelling, applied to epidemiology, social care and public health. Over this period, in Khaled's role as Principal Investigator or Co-Investigator, he has secured over £5 (£1.4 million at SHU since 2012) million of research and consultancy grants for different institutions and published over 30 articles (20 as first author), with an average impact factor of 6 across all publications in high-impact internationally peer-reviewed journals such as American Journal of Tropical Medicine, PLOS ONE and Nature (at least eight articles were considered in REF 2014 and REF 2021)

    • 2018: Khatab K (PI). Funded by SHU\HWB Strategic Research Investment Fund for the Child health and Epidemiology team. The aim of this fund was to organise a Seminar focusing on Geospatial Child Health and Epidemiology to explore the main concepts, gaps, methods and research findings relating to infants and young children – five years and under and over – from a variety of perspectives, including psychology, education and health, including approaches to assessment and intervention.

      This seminar took place in the Faculty of Health and Wellbeing at SHU on 20June 2018.

      Main themes discussed at the seminar included:  Child Morbidity and Mortality, Child & Adolescent Mental Health, Interventions & Evidence, Child Labour and Environmental Influence, to identify the social policies and programmes most effective in supporting Africa’s poorest and most vulnerable children and to elaborate on the key features underpinning their documented success.

      The focus of this proposal of research strategy and collaboration included the seminar and the collaboration with Ohio University which aligns with the priority of building on existing partnerships, further developing and creating a broad set of research strategic collaborations with other institutions and other universities, in the UK and internationally, to maintain and enhance our research excellence and reputation.
    • 2016-2018: Khatab. K (COI). Funded by Rotherham Doncaster and South Humber NHS Foundation Trust. (£69000). Evaluate the Adult Mental Health Hospital Liaison Service.
    • 2016-2018: Khatab.K (COI) (£85000). Dunhill Trust. An observational study to assess thermal comfort of frail older people in a care home setting.
    • 2015-2016: Khatab.K (Health Economics Consultant). Funded by Parkinson's Research UK (£45000). Assessing the Economic and Social Cost of Parkinson's on Patients, Carers and their Families.
    • 2016-2019: Khatab.K (COI). NIHR-10th call-invention for innovation (i4i) research (£533,432.00) Virtual Reality Prosthetics Experiential Training System using Rift.
    • 2015-2017: Khatab.K (COI). Funded by NIHR (£85,000). Clinical and demographic characteristics associated with delay in help-seeking behaviour in patients with Acute Coronary Syndrome.
    • 2015-2016: Khatab.K (COI). Funded by MS (£10,000). Tender for Models of Ex-cellence Literature Reviews. Physical Activity in People with MS.
    • 2016-2017: Khatab.K (COI). Founded by DRI (£10,000). The "Back Active" Phys-iotherapy Model of Care. A Protocol of a Service Evaluation.
    • 2016-2017: Khatab.K (COI). Funded by primary Care Sheffield Ltd,c/o Sheffield Health and Social Care NHS Foundation Trust. (£70,000).Evaluate the Sheffield Enhanced Primary Care Programme.
    • 2016-2017: Khatab.K (COI). Funded by Middlesbrough Borough Council.(£12000,000) Health Development Service Review (including Exercise on Referral) Exploring the current health development service provision and the needs and requirements for future service provision.
    • 2013-2014: Khatab.K (COI). Partnership with B.Braun Medical Ltd. (£30,000).
      Develop in-house capacity to evaluate the commercial potential of new products and services.
    • 2007-20013: Khatab.K (PI). Founded by The German Social Accident Insurance In-stitution for the energy, textile, electrical and media products sectors (EUR 1,978.000 Million). Lung diseases among different sub-cohorts of formerly asbestos exposed workers in Germany.

    Munich University, Aachen University, Qatar University and Qatar foundation, Ohio University, Cape town University, Sheffield University, University of Michigan, NIHR, MS society, DRI, CCG

  • Publications

    A list of publications is available from the institutional repository, SHURA

    J. Breckon, M. Gee, S. McLean and K. Khatab. Physical Activity in People with Multiple Sclerosis and its Health Economics Impact. Multiple Sclerosis Society pub- lication, 2015.

    K. Khatab, O.A. Adegboye, B.M. Taofeeq. A Bayesian Geoadditive multinomial modelling of risk factors among young children in Egypt, AMJT, 2015 (to be revised)

    L. Koh, T. Mohammed, A. Acquaye, T. Wiedmann, K. Khatab. Rethinking human development and resource existentiality - a supply chain approach in detoxifying the ecosystem. 2015 Science Journal (in process).

    R.Inthawong, K.Khatab, M.D. Whitfield. Reducing the associated risk factor for CVD and its impact: a case study for Thailand. the BMJ, 2015 (in process).

    R.Inthawong, K.Khatab, M.D. Whit¯eld. Health Care costs for CVD in Thailand. Journal of Epidemiology and Community Health , 2015 (in process) .

    Oranuch Thongchundee, Anil Gumber, Khaled Khatab, Leher Gumber, Efficacy and Cost of Atypical Antipsychotics in Treatment and Management of Dementia, Journal of Neurological Disorders and Stroke, 2015 (under review).

    K. Khatab, M. Felten, N.B. Kandala, G. Ghilagaber, A. Gumber, T. Kraus. Risk factors associated with asbestos-related lung diseases in Germany, EMJ, 2014, 1; 30-40 (impact: 1.2) (cited by 4).

    Khatab K. Egypt moving towards the unknown. Significance, volume 9, Issue 4, 2012, Royal Statistical Society American Association Society.

    Khatab K. The Arab Spring: Where is Egypt now? Significance, volume 9, Issue 2, 2012, Royal Statistical Society American Association Society.

    K. Khatab, M. Felten, N. Kandala, G. Ghilagaber, T. Kraus. Risk factors associated with asbestos-related lung diseases among different sub-cohorts of formerly asbestos-exposed workers in Germany, Occup Environ Med 2011; 68: Suppl 1 A71 doi:10.1136/oemed-2011-100382.23 (impact: 3.7) (cited by 8).

    Michael Felten, Khaled Khatab, Lars Knoll, Thomas Schettgen, Hendrik Muller- Berndorff, Thomas Kraus. Serial measurements of mesothelin and osteopontin in formerly asbestos-exposed power industry workers. Occup Environ Med 2011; 68: Suppl1 A71 doi:10.1136/oemed-2011-100382.230 (impact: 3.7) (cited by 7).

    KhatabK, Kandala.N-B (2011). Latent variable modelling of risk factors associated with childhood diseases: Case study for Nigeria, Asian Pacific Journal of Tropical Disease 1.3.169-176 (impact: 1.2) (cited by 6).

    Fahrmeir, Ludwig, and Khaled Khatab. Geoadditive latent variable modelling of child morbidity and malnutrition in Nigeria. Technical Report Number, 020, 2008 (cited by 5).

    Khatab Khaled and Fahrmeir Ludwig: Analysis of Childhood Morbidity with Geoadditive Probit and Latent Variable Model: A case study for Egypt. Department of Statistics: Technical Reports, Nr.21, 2008 (cited by 3).

    Books & Chapters

    Khatab K. (2013). Bayesian Geoadditive Mixed Latent Variable Models with Applications to Child Health Problems in Egypt and Nigeria, “Advanced Techniques for Modelling Maternal and Child Health in Africa”, N.B. Kandala, Springer Book ISBN: 978-94-007-6777-5 (Print) 978-94-007-6778-2 (321 downloaded)

    Khatab K. (2011). Association between Measurements of the Malnutrition Status of Children in Nigeria using Geoadditive Latent Variable Models, July 2011: InTech-open Access Publisher.

    Khatab K. (2007). Analysis of childhood diseases and malnutrition in developing countries of Africa. Dissertation, Department of Statistics, Ludwig- Maximilians-Universitaet Muenchen, Verlag: Dr. Hut. ISBN: 978-3-89963-656-7(cited by 11).

    Conference Papers & Abstracts

    K. Khatab. Social and Demographic Factors Associated with Morbidities among Young Children in Egypt: A Bayesian Geoadditive Multinomial Model BBACGR 2015, Qatar.

    Saba Masod, Anil Gumber, K. Khatab. Pattern of Government and Household Health Care Financing in Pakistan. EuHEA PhD Student Supervisor and Early Career Researcher Conference, Manchester 2014, UK.

    K. Khatab. Application of Bayesian geoadditive mixed latent variable model to the child’s health problems. ISI World Statistics Congress, Hong Kong 2013, China.

    K. Khatab. Application of Bayesian approach to the child’s health problems. ISBA 2012 World Meeting. Kyoto, Japan.

    M. Felten, Kandala N.B, Khatab K, Schettgen T, and Kraus T. Exposure with toxic substances among electronic-waste workers: Concept for multi-centre, multinational assessment study in Africa. International conference on the science of exposure assessments, Edinburgh, 2012.

    Inthawong R, Whitfield D.M, Collins K, and Khatab K. Application of the cardiovascular disease risk assessment equation in the Thai population. The 2nd Health Challenge Thailand conference, 23rd June 2012. Office of Educational Affairs, Royal Thai Embassy, London UK, 38.

    Inthawong R, Whitfield D.M, Collins K, and Khatab K. Estimating the impact of reducing cardiovascular disease risk factors in Thailand. The 1st. Health Challenge Thailand Conference, 2nd-3rd July 2011. Office of Educational Affairs, Royal Thai Embassy, London, UK, 27.

    Inthawong R, Whitfield D.M, Collins K, and Khatab K. Estimating the benefit of reducing risk factors for cardiovascular disease in Thailand: The faculty of Health and Wellbeing research day, Sheffield Hallam University, 2011.

    Felten M, Khatab K, Knoll L, Schettgen T, Berndorff H., Kraus.T. Serial measurements of mesothelin and osteopontin in formerly asbestos-exposed power industry workers. International Conference on Epidemiology in Occupational Health, Oxford University, 2011.

    Khatab K, Felten M, Kandala NB, Ghilagaber G, Kraus.T. Asbestos-related lung diseases among different sub-cohorts of formerly asbestos exposed workers in Germany.

    International Conference on Epidemiology in Occupational Health, Oxford University, 2011.

    Khatab K and Felten M. Associations of the risk factors with asbestos lung related diseases among different sub-cohorts of former asbestos workers in Germany. International Occupational Hygiene Association, Rome, 2010.

    Khatab K. Child health situation in Egypt, The 10th Conference on Statistical Sciences (CSS-X), Cairo, 23-25 December 2010.

    Kandala N.B and Khatab K. Childhood Malnutrition in DRC. Ninth Valencia International Meeting on Bayesian Statistics 2010 World Meeting of the International Society for Bayesian Analysis, Benidorm, Conference proceedings, June 3rd-June 8th, 2010.

    Khatab K. Advanced techniques in the modelling of child health problems, ISI 2009 (Chairman of session). International Statistical Institutions, 16-22 August 2009 Durban, South Africa.

    Khatab K and Fahrmeir L. Analysis of Childhood Morbidity with Geoadditive Probit and Latent Variables (ICHO, 2009, South Africa).

    Voigt M, Kno M, Khatab K, Kraus T. Deskriptive Analyse asbestbedingter Malignome ehemals exponierter Kraftwerksmitarbeiter (DGAUM, 2009).

    Khatab K Geoadditive Latent Variable Modelling of Child Morbidity and Malnutrition in Nigeria, Statistics and Life Sciences, Munich, 2008.

  • Other activities

    Editorships:

    Academic Editor, PLUSONE Journal (since 2017).

    Editorial Board, Biostatistics and Epidemiology journal (2018)
    Executive Editor in Chief, Asian Pacific Journal of Tropical Biomedicine (since 2011)
    Editorial Board, Asian Pacific Journal of Tropical Medicine (since 2011)
    Scientific Consultation Board, Royal Statistical Society, London (since 2010)

    Reviewer:

    Rater for the NIHR Dissemination Centre (since 2015
    External Examiner - Aachen University, Munich University
    Reviewer, American Journal of Tropical and Hygiene
    Reviewer, Social Science & Medicine
    Reviewer, International journal of equity and health
    Reviewer, Journal of Health and Place
    Reviewer, Journal of Nutrition & Food Sciences
    Reviewer, National Institute for Health Research (NIHR)
    Reviewer, The Economic and Social Research Council (ESRC)
    Reviewer, Medical Research Council (MRC)

  • Postgraduate supervision

    • Cost-Effectiveness of Atypical Antipsy-chotics for the treatment of Behavioural and Psychological Symptoms of Dementia in Thailand (2018).
    • Assessing the impact of reducing risk factors for cardiovascular disease in Thailand (completed, SHU, 2015).
    • Radiological surveillance of former asbestos exposed power industry workers (completed, 2013)

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