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Dr Nicola Aberdein

Lecturer

Summary

Nicola obtained a BSc with honours in Biomedical Sciences from the University of Dundee before completing her Ph.D. at Heriot-Watt University, Edinburgh on a project titled "Adipose Tissue Metabolism and Function: The Effects of Short Chain Fatty Acids". Nicola most recently spent time in the United States as Postdoctoral Research Fellow at the University of Mississippi Medical Center where she took an integrative approach to physiology investigating leptins major actions in response to diet induced obesity.  

  • About

    Nicola obtained a BSc with honours in Biomedical Sciences from the University of Dundee before completing her Ph.D. at Heriot-Watt University, Edinburgh on a project titled "Adipose Tissue Metabolism and Function: The Effects of Short Chain Fatty Acids". Nicola most recently spent time in the United States as Postdoctoral Research Fellow at the University of Mississippi Medical Center where she took an integrative approach to physiology investigating leptins major actions in response to diet induced obesity.  

  • Teaching

    Nicola teaches in the areas of Physiology and Nutrition

  • Research

    Understanding the role of protein tyrosine phosphatase 1B (PTP1B), a negative regulator of leptin signalling, in modulating the cardiometabolic responses to chronic hyperlepinemia or diet induced obesity

    Obesity currently affects more than 30% of the adult population in the U.K. and is linked with comorbidities including hepatic steatosis, type 2 diabetes and cardiovascular disease. Diet induced obesity is associated with resistance to many of leptins metabolic effects including appetite suppression and glucose regulation. Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of leptin receptor signalling and may contribute to leptin resistance in diet-induced obesity. Understanding the role PTP1B plays in mediating the cardiovascular and metabolic effects of diet induced obesity may give us insight into its use as a potential therapy against many aspects of the metabolic syndrome. 

  • Publications

    Wang Z, do Carmo JM, Aberdein N, Zhou X, Williams JM, da Silva AA, Hall JE. Synergistic Interaction of Hypertension and Diabetes in Promoting Kidney Injury and the Role of Endoplasmic Reticulum Stress Hypertension 2017 69(4)

    do Carmo JM, da Silva AA, Wang Z, Fang T, Aberdein N, Perez de Lara CE, Hall JE Role of the brain melanocortins in blood pressure regulation. Biochim Biophys Acta 2017 S0925-4439

    do Carmo JM, da Silva AA, Wang Z, Fang T, Aberdein N, de Lara Rodriguez CE, Hall JE Obesity-induced hypertension: brain signalling pathways, Current Hypertension Reports 2016 18(7): 1-9.

    Aberdein N, Schweizer M, Ball D Sodium acetate decreases phosphorylation of hormone sensitive lipase in isoproterenol stimulated 3T3-L1 mature adipocytes, Adipocyte 2014 3:2, 1-5.

    Juedtz K, Aberdein N, Stewart D, McDougall JG Sequential extraction of black currant residues produces anthocyanin-rich extracts containing anthocyanin dimmers, Journal of Berry Research 2013 3; 53-64.

    Aberdein N, do Carmo JM, Wang Z, Fang T, de Lara CP, Hall JE (2016) Role of Pro-opiomelanocortin (POMC) Specific PTP1B in Differential Regulation of Blood Pressure, Liver Lipid Accumulation and Glucose Tolerance in Response to a High Fat Diet, Council on Hypertension 2016 Proceedings: 37

    Wang Z, do Carmo JM, da Silva A, Aberdein N, Hall JE (2016) Role of Suppressor of Cytokines Signaling 3 (SOCS3) in POMC Neurons in Regulating Metabolic and Cardiovascular Functions in Dietary-Induced Obesity, Council on Hypertension 2016 Proceedings: 77

    Aberdein N, do Carmo JM, Hall JE (2016) Protein Tyrosine Phosphatase 1B (PTP1B) Deficiency In Pro-Opiomelanocortin (POMC) Neurons Does Not Enhance Leptin’s Anorexigenic Effect, But Improves Glucose Tolerance And Increases Energy Expenditure In Mice Fed A High Fat Diet, Experimental Biology 2016 Proceedings B172 961.2

    Fang T, do carmo JM, Wang J, Aberdein N, de Lara Rodriguez CE, Hall JE. (2016) Role of brainstem melanocortin-4 receptor (MC4R) in regulating glucose, energy balance and body fat in female mice, Experimental Biology 2016 Proceedings B291 750.2

    Aberdein N, do Carmo JM, Hall JE. (2015) Protein tyrosine phosphatase 1B (PTP1B) deficiency in pro-opiomelanocortin (POMC) neurons improves glucose tolerance but does not decrease body weight in mice fed a high fat diet, Southeast Regional IDeA 2015 Proceedings A3.6

     

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