Sarah received a BSc (Hons) in Biological Chemistry from Leicester University and a PhD in Cancer Studies from Sheffield University. After completing postdoctoral research at the Universities of Leeds and Sheffield, she was appointed at Sheffield Hallam University in 2009. Her primary research interests involve the role of cell biology and immunotherapy in human disease with significant expertise in immunogenic phenotyping and biomarkers.
Sarah teaches across the Faculty and is the Bioscience Lead for the Essentials of Bioscience for Nursing practice module. At postgraduate level, she leads two modules; Cellular and Molecular Basis of Cancer and Cellular Pathology. After receiving a Faculty inspirational teaching award in 2016, she was nominated for an outstanding student support award and an inspirational teaching award in 2017. Sarah was involved with the accreditation of the Biomedical Science degree.
Dr Haywood-Small is a member of the BMRC Lab Management group; actively contributing to the development and implementation of research strategies in the BMRC. After receiving external funding in 2017, she began to establish a mesothelioma research group in collaboration with local charities and clinical partners in the NHS.
Sarah teaches on a range of undergraduate and postgraduate courses relating to Biomedical Science across the Faculty, receiving recognition for her interactive anatomy lectures at the forefront of practice.
Cellular interactions and Immunoregulation in Cancer
My principal research interests involve cellular interactions and immunoregulation; especially the importance of these mechanisms in cancer.
Research over the past decade has greatly increased our understanding of non-apoptotic programmed cell death events, such as necrosis and cell death with autophagy. It is becoming clear that an intricate effector network connects many of these classical and non-classical death pathways. My primary research interest is to examine these pathways, as well as to exploit this newly gained knowledge to provide therapeutics for cancer.
Understanding the Pathogenesis of Mesothelioma
Current laboratory investigations are focussing on the physical profile of selected mineral fibres and emerging biomarkers in mesothelioma using a combination of mass spectrometry, flow cytometry and histopathology techniques. Other aims include biomarker discovery using multiplex analytical techniques and to contribute to the knowledge base surrounding mesothelioma pathogenesis. Such techniques would ultimately involve future integration into the clinical workflow; diagnosis, prognosis and treatment monitoring of mesothelioma, as well as contributing to knowledge about the pathogenesis of the disease.
Improving the Management of Fibromyalgia
Other collaborative research interests explore the life and treatment experience of people in the United Kingdom with fibromyalgia to inform the development of treatments which are both effective and acceptable to users.
Mahbub, A.A., Le Maitre, C., Haywood-Small, S., & Cross, N. (2019). Polyphenols enhance the activity of alkylating agents in leukaemia cell lines. Oncotarget, 10 (44). http://doi.org/10.18632/oncotarget.27068
Taylor, S., Steer, M., Ashe, S., Furness, P., Haywood-Small, S., & Lawson, K. (2018). Patients' perspective of the effectiveness and acceptability of pharmacological and non-pharmacological treatments of fibromyalgia. Scandinavian Journal of Pain. http://doi.org/10.1515/sjpain-2018-0116
Furness, P., Vogt, K., Ashe, S., Taylor, S., Haywood-Small, S., & Lawson, K. (2018). What causes Fibromyalgia? An online survey of patient perspectives. Health Psychology Open, 5 (2). http://doi.org/10.1177/2055102918802683
Andrews, A.M., Haywood-Small, S., Smith, T., & Stafford, P. (2017). Interactions of periodontal pathogens with megakaryocytic cells and platelets. Journal of Oral Microbiology, 9 (sup1), 1325245. http://doi.org/10.1080/20002297.2017.1325245
Arhoma, A., Chantry, A.D., Haywood-Small, S., & Cross, N. (2017). SAHA-induced TRAIL-sensitisation of Multiple Myeloma cells is enhanced in 3D cell culture. Experimental cell research. http://doi.org/10.1016/j.yexcr.2017.09.012
Mahbub, A., Le Maitre, C., Haywood-Small, S., Cross, N., & Jordan-Mahy, N. (2017). Dietary polyphenols influence antimetabolite agents: methotrexate, 6-mercaptopurine and 5-fluorouracil in leukemia cell lines. Oncotarget, 8, 104877-104893. http://doi.org/10.18632/oncotarget.20501
Ashe, S., Furness, P., Taylor, S., Haywood-Small, S., & Lawson, K. (2017). A qualitative exploration of the experiences of living with and being treated for fibromyalgia. Health Psychology Open, 4 (2), 1-12. http://doi.org/10.1177/2055102917724336
Ashe, S., Furness, P., Taylor, S., Haywood-Small, S., & Lawson, K. (2016). "Not all in my head": a qualitative exploration of living with fibromyalgia and its treatments (Oral presentation). The European Health Psychologist, 18 (Supp), 695. http://www.ehps.net/ehp/index.php/contents/article/view/2048
Mahbub, A.A., Le Maitre, C.L., Haywood-Small, S.L., Cross, N.A., & Jordan-Mahy, N. (2015). Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines. Cell Death and Disease, 6, e2028. http://doi.org/10.1038/cddis.2015.379
Mahbub, A.A., Le Maitre, C.L., Haywood-Small, S.L., Cross, N.A., & Jordan-Mahy, N. (2015). Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines. Cell Death Discovery, 1 (15043), 1-12. http://doi.org/10.1038/cddiscovery.2015.43
Zaini, R., Haywood-Small, S., Cross, N., & Le Maitre, C. (2015). Differential interactions of Falcarinol combined with anti-tumour agents on cellular proliferation and apoptosis in human lymphoid leukaemia cell lines. Journal of Blood Disorders and Transfusion, 6 (2). http://doi.org/10.4172/2155-9864.1000258
Mahbub, A.A., Le Maitre, C., Haywood-Small, S., McDougall, G.J., Cross, N., & Jordan-Mahy, N. (2013). Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines. Anti-cancer agents in medicinal chemistry, 13 (10), 1601-1613. http://doi.org/10.2174/18715206113139990303
Cole, L.M., Mahmoud, K., Haywood-Small, S., Tozer, G.M., Smith, D.P., & Clench, M.R. (2013). Recombinant "IMS TAG" proteins - A new method for validating bottom-up matrix-assisted laser desorption/ionisation ion mobility separation mass spectrometry imaging. Rapid Communications in Mass Spectrometry, 27 (21), 2355-2362. http://doi.org/10.1002/rcm.6693
Battle, R., Poole, K., Haywood-Small, S., Clark, B., & Woodroofe, N. (2012). Molecular characterisation of the monocytic cell line THP-1 demonstrates a discrepancy with the documented HLA type. International Journal of Cancer, 132 (1), 246-247. http://doi.org/10.1002/ijc.27661
Doherty, R.E., Haywood-Small, S.L., Sisley, K., & Cross, N.A. (2011). Aldehyde dehydrogenase activity selects for the holoclone phenotype in prostate cancer cells. Biochemical and Biophysical Research Communications, 414 (4), 801-807. http://doi.org/10.1016/j.bbrc.2011.10.010
Haywood-Small, S. (2017). "A Future Amalgamation Between the Scientist and the Clinician?". In Cole, L. (Ed.) Imaging mass spectrometry : methods and protocols. (pp. 1-6). New York: Humana Press: http://doi.org/10.1007/978-1-4939-7051-3_1
Theses / Dissertations
Mahbub, A.A.-.H. (2015). The anti-cancer potential of polyphenols in the treatment of leukaemia. (Doctoral thesis). Supervised by Jordan-Mahy, N., Cross, N., Le Maitre, C., & Haywood-Small, S.
Dr Haywood-Small routinely reviews grants and provides scientific support for the June Hancock Mesothelioma Research Fund.