I was appointed as a lecturer at Sheffield Hallam University in 2008 following a post doc at the University of Leeds in 2005 and post as Research Fellow at the Interdepartmental Centre of Mass Spectrometry, University of Florence, Italy (2005-2008). I teach separation and detection techniques, analytical science and bioanalytical methods. I am an internationally known researcher in the area of Bioanalytical and Forensic Mass Spectrometry and I work closely with the Home Office and West Yorkshire Police UK. I have been awarded the title of Professor of Forensic and Bioanalytical Mass Spectrometry in 2018.
I hold a degree in Chemistry and a PhD in Chemical Sciences awarded by the University of Salerno, Italy, in 2000 and 2004 respectively. The PhD was split between the Italian institution and the University of Leeds, UK, thanks to a Marie Curie Fellowship. I have been promoted to Senior Lecturer and then to Reader at Sheffield Hallam University in 2009 and 2014 respectively. I lead two undergraduate modules and one MSc module in the areas of analytical chemistry and applied research.
As an analytical chemist and mass spectrometrist, I developed my career at SHU by forming and leading a research group, engaging in commercial, media and public engagement activities, building and fostering important collaborations with prestigious partners such as the Home Office UK, West Yorkshire Police, the Ministry of Defense Science and Technology laboratory (DSTL) and the Netherlands Forensic Institute, as well as with pharmaceutical, mass spectrometry and forensic companies (e.g. GlaxoSmithKline, Waters, HTX technologies, Consolite Forensics) .
I have contributed to raise the profile of Sheffield Hallam University through pioneering research on extracting intelligence from the chemistry of fingermarks developing MALDI mass spectrometry based technologies, as testified by the funding received since 2011 from the Home Office, West Yorkshire Police and DSTL (in addition to other sources of funding), the prestigious and continuous national and international coverage by important outlets, with the BBC being one such examples, and numerous invitations to deliver presentations on national and international platforms including plenary and keynote talks (over 80 to date). The research has been so successful that MALDI MS has now been included as a Category C, TLR 3-4 technique in the Home Office Fingermark Visualisation Manual launched in 2014. I am presently the Chair of the EU COST Action CA16101 MULTI-modal Imaging of FOREnsic SciEnce Evidence (MULTI-FORESEE)- tools for Forensic Science coordinating 28 countries and more than 100 members.
I am extremely active in the research field, having published to date 57 peer reviewed papers, 4 application notes and 3 book chapters. My extensive and rounded research activities have led to my inclusion in the recent REF 2014 and in one of the impact case studies presented, becoming the Impact Coordinator for REF 2021. I was also featured in the case study for the Athena SWAN Competition in 2013 which led to the award of the silver medal and I was named "inspirational woman" in 2015 at Sheffield Hallam University.
I undertake casework for the Police in the UK and Europe and for forensic providers with respect to extracting additional intelligence from fingermarks.
I am heavily involved in teaching activities both through extensive direct contact with students and through devising learning and teaching strategies to enhance students' learning experience. I act as a referee for numerous journals and grant-awarding bodies including STW, MRC and the US Defence Army. I am member of two mass spectrometry societies, part of the prestigious International Fingermark Research Group and European Network of Forensic Science Institutes (only accepting members on invitation) and Fellow of the Higher Education.
I teach separation and detection methods with particular focus on chromatographic and advanced mass spectrometry techniques at both undergraduate and Master level. I also lead the Research Project Module guiding 250+ students towards becoming independent scientists and coordinating 50+ members of staff.
Biomolecular Sciences Research Centre
Chemical Profiling and Imaging of fingermarks
MALDI MSP and MALDI MSI method refinement for operational deployment in casework - this project focuses on maximising forensic opportunities from fingerprints by transferring laboratory MALDI MS Fingermark Profiling and Imaging techniques into protocols for routine operational use in casework. This work will represent the first significant enhancement to techniques which have remained largely unchanged for over 100 years. This project aims to deliver both offender profiling and enhance crime contextual information. Integration of these methodologies within the current fingerprinting workflows employed by Yorkshire and the Humber fingerprint identification services is an essential part of these developments. Such refined methodologies will enable robust and compatible workflows providing evidence to inform investigations and suitable to be submitted in a Court of Law. The research has been endorsed and supported by the Home Office CAST, the Defence Science and Technology Laboratory (MoD), The Netherlands Forensic Institute and West Yorkshire Police (collaborators).
Multi-informative and specific detection of blood in fingermarks via MALDI MS based strategies
In violent offences, blood is often found at crime scenes. Important intelligence and assistance in event reconstruction can be obtained from ascertaining the presence of blood, its provenance, age and its association with fingermarks (the most used means of biometric identification). Currently used blood detection techniques suffer from “false positives” due to their relatively generic molecular targets; this project aims to develop a proteomic and MALDI MS based multidisciplinary approach for the device of operational workflows providing blood signatures in fingermarks and blood provenance in addition to detecting exogenous substances of forensic relevance. Insights into the determination of the age of a blood trace and order of deposition (mark in blood or bloodied mark) as well as into the donors pathophysiological state and identity will also be gained.
The research has been endorsed and supported by the Home Office CAST, the Defence Science and Technology Laboratory (MoD), and Elite Forensics LLC (US).
Another strand of this research will shortly be the non invasive detection of cancer using fingertip smears. This project is funded by the MRC CiC scheme and will start in January 2019. The research has a primary diagnostic connotation but will feed into the plethora of information about an individual that we can gather through a fingerprint.
Cole, L., Clench, M., & Francese, S. (2019). Sample treatment for tissue proteomics in cancer, toxicology, and forensics. Adv Exp Med Biol, 1073 (1073), 77-123. http://doi.org/10.1007/978-3-030-12298-0_4
Francese, S. (2019). Criminal profiling through MALDI MS based technologies – breaking barriers towards border-free forensic science. Australian journal of forensic sciences. http://doi.org/10.1080/00450618.2018.1561949
Francese, S. (2018). Investigation of infinite focus microscopy for the determination of the association of blood with fingermarks. Science & Justice, 58 (6), 397-404. http://doi.org/10.1016/j.scijus.2018.07.001
Flinders, B., Beasley, E., Verlaan, R.M., Cuypers, E., Francese, S., Bassindale, T., ... Heeren, R.M.A. (2017). Optimization of sample preparation and instrumental parameters for the rapid analysis of drugs of abuse in hair samples by MALDI-MS/MS imaging. Journal of the American Society for Mass Spectrometry, 28 (11), 2462-2468. http://doi.org/10.1007/s13361-017-1766-0
Francese, S., Bradshaw, R., & Denison, N. (2017). An update on MALDI Mass Spectrometry based technology for the analysis of fingermarks - stepping into operational deployment. The Analyst, 142, 2518-2546. http://doi.org/10.1039/c7an00569e
Bradshaw, R., Denison, N., & Francese, S. (2017). Implementation of MALDI MS profiling and imaging methods for the analysis of real crime scene fingermarks. Analyst, 142 (9), 1581-1590. http://doi.org/10.1039/C7AN00218A
Beasley, E., Francese, S., & Bassindale, T. (2016). Detection and mapping of Cannabinoids in single hair samples through rapid derivatization- Matrix-Assisted Laser Desorption Ionization Mass Spectrometry. Analytical Chemistry, 88 (20), 10328-10334. http://doi.org/10.1021/acs.analchem.6b03551
Waller, R., Woodroofe, N., Wharton, S.B., Ince, P.G., Francese, S., Heath, P.R., ... Simpson, J.E. (2016). Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role. Journal of Neuroimmunology, 299, 139-146. http://doi.org/10.1016/j.jneuroim.2016.09.010
Bradshaw, R., Denison, N., & Francese, S. (2016). Development of operational protocols for the analysis of primary and secondary fingermark lifts by MALDI-MS Imaging. Analytical Methods, 8 (37), 6795-6804. http://doi.org/10.1039/c6ay01406b
Mitchell, C.A., Donaldson, M., Francese, S., & Clench, M. (2016). MALDI MSI analysis of lipid changes in living skin equivalents in response to emollient creams containing palmitoylethanolamide. Methods, 104, 93-100. http://doi.org/10.1016/j.ymeth.2016.02.001
Deininger, L., Patel, E., Clench, M.R., Sears, V., Sammon, C., & Francese, S. (2016). Proteomics goes forensic: detection and mapping of blood signatures in fingermarks. Proteomics, 16 (11-12), 1707-1717. http://doi.org/10.1002/pmic.201500544
Deininger, L., Patel, E., Clench, M.R., Sears, V., Sammon, C., & Francese, S. (2016). Outside Front Cover: Proteomics goes forensic: Detection and mapping of blood signatures in fingermarks. Proteomics, 16 (11-12), 1. http://doi.org/10.1002/pmic.201670110
Patel, E., Cicatiello, P., Deininger, L., Clench, M., Marino, G., Giardina, P., ... Francese, S. (2016). A proteomic approach for the rapid, multi-informative and reliable identification of blood. The Analyst, 141 (1), 191-198. http://doi.org/10.1039/c5an02016f
Patel, E., Cole, L.M., Bradshaw, R., Batubara, A., Mitchell, C.A., Francese, S., & Clench, M. (2015). MALDI-MS imaging for the study of tissue pharmacodynamics and toxicodynamics. Bioanalysis, 7 (1), 91-101. http://doi.org/10.4155/bio.14.280
Reed, H., Stanton, A., Wheat, J., Kelley, J., Davis, L., Rao, W., ... Francese, S. (2015). The Reed-Stanton press rig for the generation of reproducible fingermarks : towards a standardised methodology for fingermark research. Science & justice, 56 (1), 9-17. http://doi.org/10.1016/j.scijus.2015.10.001
Patel, E., Clench, M.R., West, A., Marshall, P.S., Marshall, N., & Francese, S. (2015). Erratum: Alternative surfactants for improved efficiency of in situ tryptic proteolysis of fingermarks (Journal of the American Society for Mass Spectrometry (2015) 26 (862-872) DOI: 10.1007/s13361-015-1140-z). Journal of the American Society for Mass Spectrometry, 26 (10), 1795. http://doi.org/10.1007/s13361-015-1216-9
Mitchell, C.A., Long, H., Donaldson, M., Francese, S., & Clench, M.R. (2015). Lipid changes within the epidermis of living skin equivalents observed across a time-course by MALDI-MS imaging and profiling. Lipids in Health and Disease, 14 (1). http://doi.org/10.1186/s12944-015-0089-z
Groeneveld, G., de Puit, M., Bleay, S., Bradshaw, R., & Francese, S. (2015). Detection and mapping of illicit drugs and their metabolites in fingermarks by MALDI MS and compatibility with forensic techniques. Scientific Reports, 5 (11716). http://doi.org/10.1038/srep11716
Bailey, M.J., Bradshaw, R., Francese, S., Salter, T.L., Costa, C., Ismail, M., ... de Puit, M. (2015). Rapid detection of cocaine, benzoylecgonine and methylecgonine in fingerprints using surface mass spectrometry. Analyst, 140 (18), 6254-6259. http://doi.org/10.1039/c5an00112a
Patel, E., Clench, M., West, A., Marshall, P.S., Marshall, N., & Francese, S. (2015). Alternative Surfactants for Improved Efficiency of In Situ Tryptic Proteolysis of Fingermarks. Journal of The American Society for Mass Spectrometry, 26 (6), 862-872. http://doi.org/10.1007/s13361-015-1140-z
Bradshaw, R., Bleay, S., Clench, M., & Francese, S. (2014). Direct detection of blood in fingermarks by MALDI MS profiling and imaging. Science & justice, 54 (2), 110-7. http://doi.org/10.1016/j.scijus.2013.12.004
Francese, S., Bradshaw, R., Ferguson, L.S., Wolstenholme, R., Clench, M.R., & Bleay, S. (2013). Beyond the ridge pattern: multi-informative analysis of latent fingermarks by MALDI mass spectrometry. The Analyst, 138 (15), 4215. http://doi.org/10.1039/c3an36896c
Bradshaw, R., Bleay, S., Wolstenholme, R., Clench, M., & Francese, S. (2013). Towards the integration of matrix assisted laser desorption ionisation mass spectrometry imaging into the current fingermark examination workflow. Forensic Science International, 232 (1-3), 111-124. http://doi.org/10.1016/j.forsciint.2013.07.013
Bradshaw, R., Wolstenholme, R., Ferguson, L.S., Sammon, C., Mader, K., Claude, E., ... Francese, S. (2013). Spectroscopic imaging based approach for condom identification in condom contaminated fingermarks. The Analyst, 138 (9), 2546. http://doi.org/10.1039/c3an00195d
Hart, P.J., Francese, S., Woodroofe, M.N., & Clench, M.R. (2013). Matrix assisted laser desorption ionisation ion mobility separation mass spectrometry imaging of ex-vivo human skin. International Journal for Ion Mobility Spectrometry, 16 (2), 71-83. http://doi.org/10.1007/s12127-013-0124-6
Ferguson, L.S., Creasey, S., Wolstenholme, R., Clench, M.R., & Francese, S. (2013). Efficiency of the dry-wet method for the MALDI-MSI analysis of latent fingermarks. Journal of Mass Spectrometry, 48 (6), 677-684. http://doi.org/10.1002/jms.3216
Francese, S., Bradshaw, R., Flinders, B., Mitchell, C., Bleay, S., Cicero, L., & Clench, M.R. (2013). Curcumin: A multipurpose matrix for MALDI mass spectrometry imaging applications. Analytical Chemistry, 85 (10), 5240-5248. http://doi.org/10.1021/ac4007396
Djidja, M.-.C., Francese, S., Claude, E., Loadman, P., Sutton, C., Shynder, S., ... Clench, M. (2013). Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging. Current Analytical Chemistry, 9 (2), 212-225. http://doi.org/10.2174/157341113805218884
Bradshaw, R., Rao, W., Wolstenholme, R., Clench, M.R., Bleay, S., & Francese, S. (2012). Separation of overlapping fingermarks by Matrix Assisted Laser Desorption Ionisation Mass Spectrometry Imaging. Forensic Science International, 222 (1), 318-326. http://doi.org/10.1016/j.forsciint.2012.07.009
Ferguson, L.S., Wulfert, F., Wolstenholme, R., Fonville, J.M., Clench, M., Carolan, V.A., & Francese, S. (2012). Direct detection of peptides and small proteins in fingermarks and determination of sex by MALDI mass spectrometry profiling. The Analyst, 137 (20), 4686-4692. http://doi.org/10.1039/c2an36074h
Seppala, U., Francese, S., Turillazi, S., Moneti, G., Clench, M., & Barber, D. (2012). In situ imaging of honeybee (Apis mellifera) venom components from aqueous and aluminum hydroxide-adsorbed venom immunotherapy preparations. Journal of Allergy and Clinical Immunology, 129 (5), 1314-1320. http://doi.org/10.1016/j.jaci.2011.10.014
Bailey, M.J., Bright, N.J., Croxton, R.S., Francese, S., Ferguson, L.S., Hinder, S., ... Bleay, S. (2012). Chemical characterization of latent fingerprints by matrix-assisted laser desorption ionization, time-of-flight secondary ion mass spectrometry, mega electron volt secondary mass spectrometry, gas chromatography/mass spectrometry, X-ray photoelectron spectroscopy, and attenuated total reflection Fourier transform infrared spectroscopic imaging: An intercomparison. Analytical Chemistry, 84 (20), 8514-8523. http://doi.org/10.1021/ac302441y
Trim, P.J., Djidja, M.-.C., Muharib, T., Cole, L.M., Flinders, B., Carolan, V., ... Clench, M. (2012). Instrumentation and software for mass spectrometry imaging -making the most of what you've got. Journal of Proteomics, 75 (16), 4931-4940.
Waller, R., Woodroofe, M.N., Francese, S., Heath, P.R., Wharton, S.B., Ince, P.G., ... Simpson, J.E. (2012). Isolation of enriched glial populations from post-mortem human CNS material by immuno-laser capture microdissection. Journal of Neuroscience Methods, 208 (2), 108-113. http://doi.org/10.1016/j.jneumeth.2012.04.014
Bradshaw, R., Wolstenholme, R., Blackledge, R.D., Clench, M.R., Ferguson, L.S., & Francese, S. (2011). A novel matrix-assisted laser desorption/ionisation mass spectrometry imaging based methodology for the identification of sexual assault suspects. Rapid Communications in Mass Spectrometry, 25 (3), 415-422. http://doi.org/10.1002/rcm.4858
Ferguson, L., Bradshaw, R., Wolstenholme, R., Clench, M., & Francese, S. (2011). Two-step matrix application for the enhancement and imaging of latent fingermarks. Analytical Chemistry, 83 (14), 5585-5591. http://doi.org/10.1021/ac200619f
Hart, P.J., Francese, S., Claude, E., Woodroofe, M.N., & Clench, M.R. (2011). MALDI-MS imaging of lipids in ex vivo human skin. Analytical and Bioanalytical Chemistry, 401 (1), 115-125. http://doi.org/10.1007/s00216-011-5090-4
Avery, J.L., McKewen, A., Flinders, B., Francese, S., & Clench, M. (2011). Matrix assisted laser desorption mass spectrometry imaging for the examination of imipramine absorption by straticell-RHE-EPI/001 an artificial model of the human epidermis. Xenobiotica, 41 (8), pp 735-742. http://doi.org/10.3109/00498254.2011.573015
Donnini, S., Finetti, F., Francese, S., Boscaro, F., Dani, F., Maset, F., ... Ziche, M. (2011). A novel protein from the serum of Python sebae, structurally homologous to γ-phospholipase A2 inhibitor, displays antitumor activity. Biochemical Journal, 440 (2), 251-262. http://doi.org/10.1042/BJ20100739
Dani, F.R., Michelucci, E., Francese, S., Mastrobuoni, G., Cappellozza, S., La Marca, G., ... Pelosi, P. (2011). Odorant-Binding Proteins and Chemosensory Proteins in Pheromone Detection and Release in the Silkmoth Bombyx mori. Chemical senses. http://doi.org/10.1093/chemse/bjq137
Baracchi, D., Francese, S., & Turillazzi, S. (2011). Beyond the antipredatory defence: honey bee venom functions as a component of social immunity. Toxicon, 58 (6-7), 550-557. http://doi.org/10.1016/j.toxicon.2011.08.017
Djidja, M.C., Claude, E., Snel, M.F., Francese, S., Scriven, P., Carolan, V., & Clench, M.R. (2010). Novel molecular tumour classification using MALDI-mass spectrometry imaging of tissue micro-array. Analytical and Bioanalytical Chemistry, 397 (2), 587-601. http://doi.org/10.1007/s00216-010-3554-6
Trim, P.J., Djidja, M.C., Atkinson, S.J., Oakes, K., Cole, L.M., Anderson, D.M.G., ... Clench, M.R. (2010). Introduction of a 20 kHz Nd:YVO4 laser into a hybrid quadrupole time-of-flight mass spectrometer for MALDI-MS imaging. Analytical and Bioanalytical Chemistry, 397 (8), 3409-3419. http://doi.org/10.1007/s00216-010-3874-6
Scollato, A., Terreni, A., Caldini, A., Salvadori, B., Gallina, P., Francese, S., ... Di Lorenzo, N. (2010). CSF proteomic analysis in patients with normal pressure hydrocephalus selected for the shunt: CSF biomarkers of response to surgical treatment. Neurological Sciences, 31 (3), 283-291. http://doi.org/10.1007/s10072-009-0181-0
Wolstenholme, R., Bradshaw, R., Clench, M.R., & Francese, S. (2009). Study of latent fingermarks by matrix-assisted laser desorption/ionisation mass spectrometry imaging of endogenous lipids. Rapid communications in mass spectrometry, 23 (19), 3031-3039. http://doi.org/10.1002/rcm.4218
Djidja, M.C., Francese, S., Loadman, P.M., Sutton, C.W., Scriven, P., Claude, E., ... Clench, M.R. (2009). Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification forin situproteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections. Proteomics, 9 (10), 2750-2763. http://doi.org/10.1002/pmic.200800624
Djidja, M.-.C., Claude, E., Snel, M.F., Scriven, P., Francese, S., Carolan, V., & Clench, M.R. (2009). MALDI-Ion Mobility Separation-Mass Spectrometry Imaging of Glucose-Regulated Protein 78 kDa (Grp78) in Human Formalin-Fixed, Paraffin-Embedded Pancreatic Adenocarcinoma Tissue Sections. Journal of Proteome Research, 8 (10), 4876-4884. http://doi.org/10.1021/pr900522m
Grossi, C., Francese, S., Casini, A., Rosi, M.C., Luccarini, I., Fiorentini, A., ... Casamenti, F. (2009). Clioquinol decreases amyloid-β burden and reduces working memory impairment in a transgenic mouse model of Alzheimer’s disease. Journal of Alzheimer's disease, 17 (2), 423-440. http://doi.org/10.3233/JAD-2009-1063
Trim, P.J., Francese, S., & Clench, M.R. (2009). Imaging mass spectrometry for the assessment of drugs and metabolites in tissue. Bioanalysis, 1 (2), 309-319. http://doi.org/10.4155/BIO.09.33
Francese, S., Dani, F.R., Traldi, P., Mastrobuoni, G., Pieraccini, G., & Moneti, G. (2009). MALDI mass spectrometry imaging, from its origins up to today: the state of the art. Combinatorial chemistry & high throughput screening, 12 (2), 156-174. http://doi.org/10.2174/138620709787315454
Cavatorta, V., Sforza, S., Mastrobuoni, G., Pieraccini, G., Francese, S., Moneti, G., ... Marchelli, R. (2009). Unambiguous characterization and tissue localization of Pru P 3 peach allergen by electrospray mass spectrometry and MALDI imaging. Journal of mass spectrometry, 44 (6), 891-897. http://doi.org/10.1002/jms.1562
Francese, S., Lambardi, D., Mastrobuoni, G., la Marca, G., Moneti, G., & Turillazzi, S. (2009). Detection of honeybee venom in envenomed tissues by direct MALDI MSI. Journal of the American Society for Mass Spectrometry, 20 (1), 112-123. http://doi.org/10.1016/j.jasms.2008.09.006
Dani, F.R., Francese, S., Mastrobuoni, G., Felicioli, A., Caputo, B., Simard, F., ... Turillazzi, S. (2008). Exploring Proteins in Anopheles gambiae Male and Female Antennae through MALDI Mass Spectrometry Profiling. PLoS ONE, 3 (7), e2822. http://doi.org/10.1371/journal.pone.0002822
La Marca, G., Malvagia, S., Filippi, L., Fiorini, P., Innocenti, M., Luceri, F., ... Guerrini, R. (2008). Rapid assay of topiramate in dried blood spots by a new liquid chromatography-tandem mass spectrometric method. Journal of Pharmaceutical and Biomedical Analysis, 48 (5), 1392-1396. http://doi.org/10.1016/j.jpba.2008.09.025
Casini, A., Gabbiani, C., Mastrobuoni, G., Pellicani, R.Z., Intini, F.P., Arnesano, F., ... Messori, L. (2007). Insights into the molecular mechanisms of protein platination from a case study: The reaction of anticancer platinum(II) iminoethers with horse heart cytochrome C. Biochemistry, 46 (43), 12220-12230. http://doi.org/10.1021/bi701516q
Stockley, P.G., Rolfsson, O., Thompson, G.S., Basnak, G., Francese, S., Stonehouse, N.J., ... Ashcroft, A.E. (2007). A Simple, RNA-Mediated Allosteric Switch Controls the Pathway to Formation of a T = 3 Viral Capsid. Journal of Molecular Biology, 369 (2), 541-552. http://doi.org/10.1016/j.jmb.2007.03.020
Turillazzi, S., Bruschini, C., Lambardi, D., Francese, S., Spadolini, I., & Mastrobuoni, G. (2007). Comparison of the medium molecular weight venom fractions from five species of common social wasps by MALDI-TOF spectra profiling. Journal of Mass Spectrometry, 42 (2), 199-205. http://doi.org/10.1002/jms.1152
Casini, A., Mastrobuoni, G., Temperini, C., Gabbiani, C., Francese, S., Moneti, G., ... Messori, L. (2007). ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme. Chemical Communications, (2), 156-158. http://doi.org/10.1039/b611122j
Prosinecki, V., Botelho, H.M., Francese, S., Mastrobuoni, G., Moneti, G., Urich, T., ... Gomes, C.M. (2006). A proteomic approach toward the selection of proteins with enhanced intrinsic conformational stability. Journal of Proteome Research, 5 (10), 2720-2726. http://doi.org/10.1021/pr0602491
Stockley, P.G., Ashcroft, A.E., Francese, S., Thompson, G.S., Ranson, N.A., Smith, A.M., ... Stonehouse, N.J. (2005). Dissecting the fine details of assembly of a T = 3 phage capsid. Journal of Theoretical Medicine, 6 (2), 119-125. http://doi.org/10.1080/10273660500149869
Francese, S., Cozzolino, A., Caputo, I., Esposito, C., Martino, M., Gaeta, C., ... Neri, P. (2005). Transglutaminase surface recognition by peptidocalixarene diversomers. Tetrahedron Letters, 46 (10), 1611-1615. http://doi.org/10.1016/j.tetlet.2005.01.078
Ruoppolo, M., Orrù, S., D'Amato, A., Francese, S., Rovero, P., Marino, G., & Esposito, C. (2003). Analysis of transglutaminase protein substrates by functional proteomics. Protein Science, 12 (6), 1290-1297. http://doi.org/10.1110/ps.0239103
Ruoppolo, M., Orrù, S., Francese, S., Caputo, I., & Esposito, C. (2003). Structural characterization of transglutaminase-catalyzed cross-linking between glyceraldehyde 3-phosphate dehydrogenase and polyglutamine repeats. Protein Science, 12 (1), 170-179. http://doi.org/10.1110/ps.0216103
Orru, S., Ruoppolo, M., Francese, S., Vitagliano, L., Marino, G., & Esposito, C. (2002). Identification of tissue transglutaminase-reactive lysine residues in glyceraldehyde-3-phosphate dehydrogenase. Protein Science, 11 (1), 137-146. http://doi.org/10.1110/ps.ps.17102
Rolfsson, O., Toropova, K., Morton, V., Francese, S., Basnak, G., Thompson, G.S., ... Stockley, P.G. (2008). RNA Packing Specificity and Folding during Assembly of the Bacteriophage MS2. Computational and Mathematical Methods in Medicine, 9 (3-4), 339-349. http://doi.org/10.1080/17486700802168445
Moneti, G., Francese, S., Mastrobuoni, G., Pieraccini, G., Seraglia, R., Valitutti, G., & Traldi, P. (2007). Do collisions inside the collision cell play a relevant role in CID-LIFT experiments? Journal of Mass Spectrometry, 42 (1), 117-126. http://doi.org/10.1002/jms.1151
Francese, S. (2015). Techniques for fingermark analysis using MALDI MS: A practical overview. In Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry. (pp. 93-128). http://doi.org/10.1007/978-3-319-04819-2_6
Reed, H., Stanton, A., & Francese, S. (2014). Design as mediation. In Designa 2013 : interface. Proceedings. (pp. 191-208). Covilha: Universidade da Beira Interior (UBI)
Francese, S., & Clench, M.R. (2010). MALDI Mass Spectrometry Imaging, a New Frontier in Biostructural Techniques: Applications in Biomedicine. In Shah, H.N., & Gharbia, S.E. (Eds.) Mass Spectrometry for Microbial Proteomics. (pp. 91-116). Wiley: http://doi.org/10.1002/9780470665497.ch5
Theses / Dissertations
Deininger, L. (2018). Multi-Informative and Specific Detection of Blood inFingermarks via MALDI-MS Based Strategies. (Doctoral thesis). Supervised by Francese, S. http://doi.org/10.7190/shu-thesis-00096
Martin, S. (2016). Identification and mechanistic study of novel drug metabolites by LC-MS. (Doctoral thesis). Supervised by Lenz, E., Clench, M., Francese, S., & Temesi, D.
Hart, P.J. (2012). MALDI-MS investigation of skin and its response to irritants and sensitisers. (Doctoral thesis). Supervised by Clench, M., Woodroofe, N., & Francese, S.
Reed, H., Francese, S., Wheat, J., & Wolstenholme, R. (2014). POWDER DISCHARGE GUN. WO2014016563 (A1). http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20140130&CC=WO&NR=2014016563A1&KC=A1
PhD external examiner
External Examiner for distance learning MSc forensic programme; Media and lay audience engagement
Cameron Heaton - "Human identification through advanced forensic mass spectrometry of blood and fingermarks" (Oct 2017-Oct 2020)
Oct 2014 - Oct 2017 - Lisa Deininger - "Multi-informative and specific detection of blood in fingermarks via MALDI MS based strategies"
Nov 2012 - Nov 2016 - Ekta Patel - "Using ion mobility mass spectrometry to investigate the distribution and affect of dosed compounds on endogenous molecules"
Nov 2014 - Apr 2016 - Robert Bradshaw - "Chemical Profiling of fingermarks : MALDI MSP and MALDI MSI method refinement for operational deployment in casework”
Oct 2011 - Oct 2014 - Robert Bradshaw - “Integration of MALDI MSI into the Home Office operational fingermark examination workflow”
Oct 2009 - Oct 2012 - Leesa Ferguson - “Analysis of composition of latent fingerprints by spectroscopic imaging techniques”
Recent stories about my fingermark research have attracted worldwide coverage in trade and online publications, including BBC's 'The One Show', 'Click', 'Crimewatch Roadshaw' and 'BBC breakfast', as well as overseas programmes such as the German 'Finde den Lügner' ('Find the Liar').