Samrein Ahmed

Dr Samrein Ahmed MBBS, MSc, FHEA, PhD

Lecturer in Cancer and Cell Biology


I am a cancer biologist with 10-year experience in the field. I was appointed as Cancer and Cell Biology lecturer at the department of Biosciences and Chemistry, Sheffield Hallam University in 2021. I have more than 7-year experience in higher education; part of it was in United Arab Emirates, which gave me a wide experience in higher education and improved my inclusive practice in teaching. Additionally, I am a fellow in higher education, UK. Alongside my teaching, my research focuses on studying cell signalling in cancer and finding the link between the metabolic diseases and cancer. 


After completing my medical degree, I pursued a career path in research and academia. I obtained my PhD degree from University of Leicester, UK. I was then appointed as research associate at the Department of Biochemistry, University of Cambridge, UK. I joined University of Sharjah, UAE, as assistant professor of Biochemistry. I taught medical biochemistry and cancer biology. I organised “We speak Science” event to foster the staff research collaboration and founded “The Researchers Club” for early career researchers. Beside these, I was awarded two targeted grants from the University and one grant from Al Jalila foundation, Dubai, UAE. 
To keep my networks active, I am a member in different international and national bodies. I am ambassador for European association for cancer research, and a member in Organization for Women in Science for the Developing World, Royal Society of Biology.


Department of Biosciences and Chemistry

College of Health, Wellbeing and Life Sciences

My teaching spans over undergraduates and postgraduates’ modules

Undergraduates teaching:
• Pathological basis of disease
• Cellular Pathology and infection
Postgraduates teaching:
• Mechanisms of disease (leading this module)
• Cell biology
• Hallmarks of cancer
• Therapeutics targeting in cancer.



• Ahmed, S.B.M.; Radwan, N.; Amer, S.; Saheb Sharif-Askari, N.; Mahdami, A.; Samara, K.A.; Halwani, R.; Jelinek, H.F. Assessing the Link between Diabetic Metabolic Dysregulation and Breast Cancer Progression. Int. J. Mol. Sci. 2023, 24, 11816.
• Rayan A Hago, Sook P Wong, Mahmood Y Hachim, Ibrahim Y Hachim, Maha Saber-Ayad, Sally A Prigent and Samrein BM Ahmed*. Nischarin negatively impacts ShcD-mediated tumor cell migration. bioRxiv. Doi:
• Salma Eldesouki, Kamel A Samara, Rama Qadri, Anas A Obaideen, Ahmad H Otour, Omar Habbal, Samrein BM Ahmed. XIST in Brain Cancer. Clin Chim Acta 2022, 1;531:283-290. doi: 10.1016/j.cca.2022.04.993
• Md Abdul Alim Al-Bari, Yuko Ito, Samrein Ahmed, Nada Radwan, Hend S Ahmed, Nabil Eid. Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer. Int J Mol Sci 2021, 10;22(18):9807. doi: 10.3390/ijms22189807.
• Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Samrein BM Ahmed, Suad Hannawi, Rifat Hamoudi, Qutayba Hamid, Rabih Halwani. Enhanced expression of autoantigens during SARS-CoV-2 viral infection. Front Immunol. 2021; 12: 686462
• Ahmad Mokhtar AMB, Ahmed SBM, Darling NJ, Harris M, Mott HR, Owen D. A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases. Biochemistry. 2021.
• Ahmed SBM, Amer S, Hussein A, D DK, Al Hasham N, M MA, Shawa N, Saleh D, K OA: Assessing the Knowledge of Environmental Risk Factors for Cancer among the UAE Population: A Pilot Study. Int J Environ Res Public Health 2020, 17(9).
• Alfarouk KO, Ahmed SBM and et al. The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH. Metabolites 2020, 10(7): 285.
• Alfarouk KO, Ahmed SBM, Ahmed A, Elliott RL, Ibrahim ME, Ali HS, Wales CC, Nourwali I, Aljarbou AN, Bashir AHH et al: The Interplay of Dysregulated pH and Electrolyte Imbalance in Cancer. Cancers (Basel) 2020, 12(4).
• El-Haj BM, Ahmed SBM: Metabolic-Hydroxy and Carboxy Functionalization of Alkyl Moieties in Drug Molecules: Prediction of Structure Influence and Pharmacologic Activity. Molecules 2020, 25(8).
• Ahmed SBM, Amer S, Emad M, Rahmani M, Prigent SA: Studying the ShcD and ERK interaction under acute oxidative stress conditions in melanoma cells. Int J Biochem Cell Biol 2019, 112:123-133.
• Cardone RA, Alfarouk KO, Elliott RL, Alqahtani SS, Ahmed SBM, Aljarbou AN, Greco MR, Cannone S, Reshkin SJ: The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela. Int J Mol Sci 2019, 20(15).
• Amer S, Alsayegh F, Mashaal Z, Mohamed S, Shawa N, Rajan K, Ahmed SBM: Role of TGFbeta in the motility of ShcD overexpressing 293 cells. Mol Med Rep 2019, 20(3):2667-2674.
• El-Haj BM, Ahmed SBM, Garawi MA, Ali HS: Linking Aromatic Hydroxy Metabolic Functionalization of Drug Molecules to Structure and Pharmacologic Activity. Molecules 2018, 23(9).
• Mabruka ZA, Ahmed SBM, Thomasa AC, Prigent SA (2018) The role of the ShcD and RET interaction in neuroblastoma survival and migration. Biochem and Biophy Rep 13: 99–108.
• Awad SHA, Ibrahim MEEAEAM, Khan GF, Ahmed SBM (2018) GHRH-R Expression Level under Hyperglycaemic Like Culture Conditions in Breast Cancer Cell Lines. Biol Med (Aligarh) 10: 428. doi:10.4172/0974-8369.1000428
• Ahmed SBM, Prigent SA (2017). Insights into the Shc Family of Adaptor Proteins. J Mol Sig: 12:2. DOI:
• Ali S.H., Ahmed SBM., Khan A.G. (2016). Gold nanoparticles in in cancer therapy and diagnostics ejpmr: 3: 54-67
• Ahmed, SBM. and Prigent, SA. (2014). A nuclear export signal and oxidative stress regulate ShcD subcellular localisation: A potential role for ShcD in the nucleus. Cell Signal: 26, 32-40.

• ShcD is a gene that was first identified in 2007. Since then, it has been linked to different cancer, importantly melanoma and gliomas. I am therefore interested in studying the oncogenic role of ShcD in melanoma and glioblastoma using CRISPR-Cas 9 technique and DESI-MSI plus other techniques.
• RLIP76 is a multifunctioning protein and its role in drug efflux is quite intriguing.
I am keen to further investigate the role of RLIP76 in pancreatic cancer in relation to its drug transport function via using Site directed mutagenesis and LC-MS and other techniques.
• With the rising evidence for the metabolic diseases as a contributor to cancer development and poor outcomes, particularly in breast and colorectal cancers, I am interested in studying the interplay between metabolic diseases and cancer.  Our recent publication revealed that hyperglycaemia and hyperinsulinemia affect gene expression in breast cancer cells, which prompted us to study this further.


Journal articles

Ahmed, S.B.M., Radwan, N., Amer, S., Saheb Sharif-Askari, N., Mahdami, A., Samara, K.A., ... Jelinek, H.F. (2023). Assessing the link between diabetic metabolic dysregulation and breast cancer progression. International Journal of Molecular Sciences, 24 (14).

Eldesouki, S., Samara, K.A., Qadri, R., Obaideen, A.A., Otour, A.H., Habbal, O., & Ahmed, S. (2022). XIST in Brain Cancer. Clinica Chimica Acta, 531, 283-290.

Ali, I., Ahmed, S., Elhaj, B.M., Ali, H.S., Alsubaie, A., & Almalki, A.S.A. (2021). Enhanced anticancer activities of curcumin-loaded green gum acacia-based silver nanoparticles against melanoma and breast cancer cells. Applied Nanoscience (Switzerland), 11 (11), 2679-2687.

Al-Bari, M.A.A., Ito, Y., Ahmed, S., Radwan, N., Ahmed, H.S., & Eid, N. (2021). Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer. International Journal of Molecular Sciences, 22 (18).

Postgraduate supervision

I have supervised 2 MRes projects, 2 MSci projects and co-supervising a PhD student.

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