Susan Campbell | Sheffield Hallam University

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Susan Campbell

Dr Susan Campbell B.A (Mod) Microbiology, PhD, FHEA

Senior Lecturer In Biological Sciences

Summary

I was appointed to a lecturing post at Sheffield Hallam in 2013.  Previous to this I carried out postdoctoral research at the University of Manchester. My research interests include the regulation of protein synthesis. My teaching interests include the development of innovative teaching methods for developing practical skills for scientists and I am the module leader for the year 1 Professional and Scientific Practice - Labs module. I am also the admissions tutor for the Department of Biosciences and Chemistry and the local ambassador for the Biochemical Society.

  • About

    I was awarded my BA (Mod) in Microbiology from Trinity College Dublin, Ireland.  I continued my studies at Trinity College and completed a PhD entitled 'The regulation of 3' end processing under the supervision of Prof Ursula Bond.  I continued with Prof Bond as a research associate investigating the adaptation of yeast brewing stress to high wort environments  before moving initially to UMIST and then to The University of Manchester, where I carried out postdoctoral research on the impact of environmental stress on translation initiation in yeast, in the lab of Dr Mark Ashe.

    In 2013 I took up the position of Senior Lecturer at Sheffield Hallam University, my research focusses on how the localisation of proteins within cells impacts upon their function. It is becoming increasingly evident that compartmentalisation of the cytoplasm of cells into discrete regions, enables efficient control of translation initiation.  Understanding the regulation of this localisation is a key theme within my research. In particular, I am interested in how the compartmentalisation of translation initiation factors within a cell impact upon their function and how this may be important in addressing the molecular mechanisms behind diseases classically associated with translational deregulation. In particular, the neurodegenerative disease childhood ataxia with central nervous system hypomyelination (CACH) or leukoencephalopathy with vanishing white matter (VWM) has been linked to mutations in the translation initiation complex eIF2B and the molecular mechanisms behind how these mutations may impact upon these complexes of eIF2B is a key question within my research.

  • Teaching

    Professional and Scientific Practice labs and skills

    Essential Biosciences, Advanced Cell Biology, Immunology and Microbiology

  • Research

    My research focusses on the control of translation initiation in response to stress conditions in the budding yeast Saccharomyces cerevisiae. During translation initiation the Met-tRNAi is recruited to the 40S ribosomal subunit in a ternary complex with eIF2-GTP. On identification of an AUG codon the eIF2-GTP is hydrolysed releasing eIF2-GDP from the complex. One of the key regulatory steps in the translation initiation pathway involves the recycling of inactive GDP-bound eIF2 into active GTP-bound eIF2. This step is catalysed by the guanine nucleotide exchange factor eIF2B. Stresses such as nutritional starvation directly target this exchange factor by activation of a kinase, which phosphorylates the alpha subunit of the G protein eIF2. This phosphorylation inhibits the exchange activity of eIF2B thereby down-regulating translation initiation.

    Localisation of translation initiation factors

    We are interested in how the localisation of factors involved in the translation initiation pathway impact upon the control of translation initiation. We have identified that both eIF2B and eIF2, localise to a cytoplasmic body termed ‘the eIF2B body’. Evidence from live cell imaging techniques such as FRAP (fluorescent recovery after photobleaching) suggest that eIF2 shuttles between the cytoplasm and these bodies and that this rate of shuttling alters in response to stresses which directly target the eIF2B exchange reaction.
    Therefore these eIF2B bodies may be sites where eIF2B catalyses the exchange of inactive eIF2xGDP for active eIF2xGTP and therefore form centres within the cells for the regulation of translation initiation. Future studies will aim to determine the precise function, structure and requirement for the eIF2B body within yeast cells.

    eIF2B mutations and human genetic diseases

    The neurological disorder Leukoencephalopathy with Vanishing white matter (VWM) has been linked to mutations in these subunits of eIF2B.  Currently, over 150 missense mutations in eIF2B have been identified however the mechanism of eIF2B involvement in the pathogenesis of this disease remains elusive. Although eIF2B is a global regulator of protein synthesis, the phenotypic effect of the mutations is only observed in oligodendrocytes and astrocytes within the brain. 

    We have identified eIF2B bodies in mammalian cells and more specifically in cells linked to the pathology of VWM. Using a GFP tagged eIF2Bε subunit, live cell imaging studies suggest that eIF2B bodies are present within human glial cells. The distribution of eIF2B bodies in these cells reveals heterogeneous populations differing in size and abundance. We are currently investigating the functional importance of these eIF2B bodies with respect to translational control and VWM disease.

  • Publications

    Journal articles

    Knowles, A., Campbell, S., Cross, N., & Stafford, P. (2021). Bacterial manipulation of the Integrated Stress Response: a new perspective on infection. Frontiers in Microbiology, 12. http://doi.org/10.3389/fmicb.2021.645161

    Norris, K., Hodgson, R., Dornelles, T., Allen, K.E., Abell, B., Ashe, M.P., & Campbell, S.G. (2020). Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease. Journal of Biological Chemistry. http://doi.org/10.1074/jbc.RA120.014956

    Lacey, M.M., Campbell, S.G., Shaw, H., & Smith, D. (2020). Self-selecting peer groups formed within the laboratory environment have a lasting effect on individual student attainment and working practices. FEBS Open Bio. http://doi.org/10.1002/2211-5463.12902

    Hodgson, R.E., Varanda, B.A., Ashe, M.P., Allen, K.E., & Campbell, S. (2019). Cellular eIF2B subunit localisation: implications for the integrated stress response and its control by small molecule drugs. Molecular biology of the cell, 30 (8), 933-1049. http://doi.org/10.1091/mbc.E18-08-0538

    Greene, C., Kealy, J., Humphries, M.M., Gong, Y., Hou, J., Hudson, N., ... Campbell, M. (2017). Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia. Molecular psychiatry, 3 (11), 2156-2166. http://doi.org/10.1038/mp.2017.156

    Lui, J., Castelli, L.M., Pizzinga, M., Simpson, C.E., Hoyle, N.P., Bailey, K.L., ... Ashe, M.P. (2014). Granules harboring translationally active mRNAs provide a platform for P-Body formation following stress. Cell Reports, 9 (3), 944-954. http://doi.org/10.1016/j.celrep.2014.09.040

    Castelli, L.M., Lui, J., Campbell, S., Rowe, W., Zeef, L.A., Holmes, L.E., ... Ashe, M.P. (2011). Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S pre-initiation complex accumulation, while the pentose phosphate pathway is co-ordinately up-regulated. Molecular Biology Of The Cell, 22 (18), 3379-3393. http://doi.org/10.1091/mbc.E11-02-0153

    Singh, C.R., Watanabe, R., Zhou, D., Jennings, M.D., Fukao, A., Lee, B., ... Asano, K. (2011). Mechanisms of translational regulation by a human eIF5-mimic protein. Nucleic Acids Research, 39 (19), 8314-8328. http://doi.org/10.1093/nar/gkr339

    Singh, C.R., Watanabe, R., Zhou, D., Jennings, M.D., Fukao, A., Lee, B., ... Asano, K. (2011). Mechanisms of translational regulation by a human eIF5-mimic protein. Nucleic acids research, 39 (19), 8314-8328.

    Taylor, E.J., Campbell, S., Griffiths, C.D., Reid, P.J., Slaven, J.W., Harrison, R.J., ... Ashe, M.P. (2010). Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body. Molecular Biology Of The Cell, 21 (13), 2202-2216. http://doi.org/10.1091/mbc.E09-11-0962

    Lui, J., Campbell, S., & Ashe, M.P. (2010). Inhibition of translation initiation following gucose depletion in yeast facilitates a arationalization of mRNA content. Biochemical Society Transactions, 38 (4), 1131-1136. http://doi.org/10.1042/BST0381131

    Miles, W.O., Jaffray, E., Campbell, S., Takeda, S., Bayston, L.J., Basu, S.P., ... Ashe, H.L. (2008). Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo. Genes and Development, 22 (18), 2578-2590. http://doi.org/10.1101/gad.494808

    James, T.C., Usher, J., Campbell, S., & Bond, U. (2008). Lager yeasts possess dynamic genomes that undergo rearrangements and gene amplification in response to stress. Current genetics, 53 (3), 139-152. http://doi.org/10.1007/s00294-007-0172-8

    Campbell, S.G., Del Olmo, M., Beglan, P., & Bond, U. (2008). A sequence element downstream of the yeast HTB1 gene contributes to mRNA 3′ processing and cell cycle regulation (Molecular and Cellular Biology (2002) 22, 24, (8415-8425)). Molecular and Cellular Biology, 28 (5), 1873. http://doi.org/10.1128/MCB.02229-07

    Hoyle, N.P., Castelli, L.M., Campbell, S., Holmes, L.E.A., & Ashe, M.P. (2007). Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies. Journal of Cell Biology, 179 (1), 65-74. http://doi.org/10.1083/jcb.200707010

    Rohde, J.R., Campbell, S., Zurita-Martinez, S.A., Cutler, N.S., Ashe, M., & Cardenas, M.E. (2004). TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Molecular and cellular biology, 24 (19), 8332-8341. http://doi.org/10.1128/MCB.24.19.8332-8341.2004

    Holmes, L.E.A., Campbell, S., De Long, S.K., Sachs, A.B., & Ashe, M.P. (2004). Loss of translational control in yeast compromised for the major mRNA decay pathway. Molecular and cellular biology, 24 (7), 2998-3010. http://doi.org/10.1128/MCB.24.7.2998-3010.2004

    James, T.C., Campbell, S., Donnelly, D., & Bond, U. (2003). Transcription profile of brewery yeast under fermentation conditions. Journal of applied microbiology, 94 (3), 432-48. http://doi.org/10.1046/j.1365-2672.2003.01849.x

    Campbell, S., Li Del Olmo, M., Beglan, P., & Bond, U. (2002). A sequence element downstream of the yeast HTB1 gene contributes to mRNA 3' processing and cell cycle regulation. Molecular and cellular biology, 22 (24), 8415-8425. http://doi.org/10.1128/MCB.22.24.8415-8425.2002

    James, T.C., Campbell, S.G., & Bond, U.M. (2002). Comparative analysis of global gene expression in lager and laboratory yeast strains grown in wort. Proceedings of the IEEE, 90 (12), 1887-1899. http://doi.org/10.1109/JPROC.2002.805300

    Bond, U., Campbell, S.G., & James, T.C. (2001). A model organism for genomic and postgenomic studies: The vast amount of genetic data available on saccharomyces cerevisiae provides important clues. IEEE Engineering in Medicine and Biology Magazine, 20 (4), 22-32. http://doi.org/10.1109/51.940040

    Book chapters

    Campbell, S.G., & Ashe, M.P. (2007). An Approach to Studying the Localization and Dynamics of Eukaryotic Translation Factors in Live Yeast Cells. (pp. 33-45). http://doi.org/10.1016/S0076-6879(07)31003-3

    Theses / Dissertations

    Hodgson, R.E. (2019). eIF2B bodies and their role in the integrated stress response. (Doctoral thesis). Supervised by Campbell, S. http://doi.org/10.7190/shu-thesis-00240

    Norris, K.F. (2018). eIF2B Bodies and their Role in the Control ofProtein Synthesis. (Doctoral thesis). Supervised by Campbell, S. http://doi.org/10.7190/shu-thesis-00129

    Norris, K.F. (2018). eIF2B Bodies and their Role in the Control ofProtein Synthesis. (Doctoral thesis). Supervised by Campbell, S. http://doi.org/10.7190/shu-thesis-00129

    Media

    Campbell, S., & Allen, E. (2019). Tackling a rare brain disease that affects children. [Video].

    Campbell, S., & Allen, E. (2019). Tackling a rare brain disease that affects children. [Video].

    Presentations

    Campbell, S. (2019). eIF2B bodies as a diagnostic tool for Leukoencephalopathy with Vanishing White Matter. Presented at: Translational Research in Paediatric Rare Diseases Symposium, Wellcome Trust Conference Centre, London

    Campbell, S. (2019). eIF2B bodies as a diagnostic tool for Leukoencephalopathy with Vanishing White Matter. Presented at: Translational Research in Paediatric Rare Diseases Symposium, Wellcome Trust Conference Centre, London

    Campbell, S. (2019). eIF2B bodies as a diagnostic tool for Leukoencephalopathy with Vanishing White Matter. Presented at: Translational Research in Paediatric Rare Diseases Symposium, Wellcome Trust Conference Centre, London

    Campbell, S., & Rawlinson, K. (2019). Integrating Public Engagement and Outreach into the Science Curriculum. Presented at: Bioscience Education Summit, UCL, London

    Campbell, S. (2019). The control of protein synthesis in stress and disease.

    Campbell, S. (2019). The control of protein synthesis in stress and disease.

    Campbell, S. (2019). The control of protein synthesis in stress and disease.

    Hodgson, R., Campbell, S., & Allen, K. (2018). eIF2B subunits localise to distinct populations of eIF2B bodies that allow for differential regulation by the ISR. Presented at: Translation UK, The University of Manchester

    Hodgson, R., Campbell, S., & Allen, K. (2018). eIF2B subunits localise to distinct populations of eIF2B bodies that allow for differential regulation by the ISR. Presented at: Translation UK, The University of Manchester

    Hodgson, R., Campbell, S., & Allen, K. (2018). eIF2B subunits localise to distinct populations of eIF2B bodies that allow for differential regulation by the ISR. Presented at: Translation UK, The University of Manchester

    Campbell, S. (2017). eIF2B bodies: regulators of translation in cells. Presented at: Gene Regulation Seminar Series, The University of Manchester

    Campbell, S. (2017). eIF2B bodies: regulators of translation in cells. Presented at: Gene Regulation Seminar Series, The University of Manchester

    Campbell, S. (2017). eIF2B bodies: regulators of translation in cells. Presented at: Gene Regulation Seminar Series, The University of Manchester

    Campbell, S. (2017). Alternative routes to Independence. Presented at: Athena Swan Seminar Series, The Babraham Institute, Campbridge

    Campbell, S. (2017). Alternative routes to Independence. Presented at: Athena Swan Seminar Series, The Babraham Institute, Campbridge

    Campbell, S. (2017). Alternative routes to Independence. Presented at: Athena Swan Seminar Series, The Babraham Institute, Campbridge

    Hodgson, R., Allen, K., & Campbell, S. (2016). eIF2B subcomplexes in cells linked to Vanishing White Matter Disease pathology. Presented at: Sheffield Glial Symposium, Sheffield Hallam University

    Hodgson, R., Allen, K., & Campbell, S. (2016). eIF2B subcomplexes in cells linked to Vanishing White Matter Disease pathology. Presented at: Sheffield Glial Symposium, Sheffield Hallam University

    Hodgson, R., Allen, K., & Campbell, S. (2016). eIF2B subcomplexes in cells linked to Vanishing White Matter Disease pathology. Presented at: Sheffield Glial Symposium, Sheffield Hallam University

    Campbell, S. (2016). eIF2B bodies: their role in the control of translation and leukoencephalopathy with vanishing white matter.

    Campbell, S. (2016). eIF2B bodies: their role in the control of translation and leukoencephalopathy with vanishing white matter.

    Campbell, S. (2016). eIF2B bodies: their role in the control of translation and leukoencephalopathy with vanishing white matter.

    Campbell, S., Hoyle, N., Griffiths, C., & Ashe, M. (2005). Discrete cytoplasmic foci represent sites of eIF2 and eIF2B localisation in the yeast Saccharoymces cerevisiae. Presented at: Translation UK, The University of Glasgow

    Campbell, S. (2005). eIF2B bodies and their role in translation initiation. Presented at: Translation UK, University of Glasgow

    Campbell, S., & Ashe, M. (2005). Discrete cytoplasmic foci represent sites of eIF2 and eIF2B localisation in the yeast Saccharomyces cerevisiae. Presented at: British Yeast Group Meeting

    Posters

    Garrard, K., Allen, K., Campbell, S., Beauchamp, N., Panayi, M., & Mordekar, S. (2021). Genetic Diagnostic Rates in Paediatric Ataxia. Presented at: 47th Annual meeting of the British Paediatric Neurology Association, virtual

    Garrard, K., Allen, K., Campbell, S., Beauchamp, N., Panayi, M., & Mordekar, S. (2021). Genetic Diagnostic Rates in Paediatric Ataxia. Presented at: 47th Annual meeting of the British Paediatric Neurology Association, virtual

    Knowles, A., Campbell, S., & Stafford, P. (2020). Characterising the role of the ISR in the pathomechanism of the Periodontopathogen Porphyromonas gingivalis. Presented at: Translational Control (Virtual), Cold Spring Harbor Laboratories, Long Island, USA

    Knowles, A., Campbell, S., & Stafford, P. (2020). Characterising the role of the ISR in the pathomechanism of the Periodontopathogen Porphyromonas gingivalis. Presented at: Translational Control (Virtual), Cold Spring Harbor Laboratories, Long Island, USA

    Knowles, A., Campbell, S., & Stafford, P. (2020). Characterising the role of the ISR in the pathomechanism of the Periodontopathogen Porphyromonas gingivalis. Presented at: Translational Control (Virtual), Cold Spring Harbor Laboratories, Long Island, USA

    Campbell, S., Allen, K., & Hodgson, R. (2020). eIF2B bodies―Implications for the ISR and disease phenotypes. Presented at: Translational Control (Virtual), Cold Spring Harbor Laboratories

    Campbell, S., Allen, K., & Hodgson, R. (2020). eIF2B bodies―Implications for the ISR and disease phenotypes. Presented at: Translational Control (Virtual), Cold Spring Harbor Laboratories

    Hanson, F., Cross, A., Allen, K., & Campbell, S. (2020). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: Cold Spring Harbor meeting: Translational Control (Virtual), Cold Spring Harbor Laboratories

    Hanson, F., Cross, A., Allen, K., & Campbell, S. (2020). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: Cold Spring Harbor meeting: Translational Control (Virtual), Cold Spring Harbor Laboratories

    Hanson, F., Allen, K., Cross, A., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: XIV European Meeting on Glial Cells in Health and Disease, Porto, Portugal

    Hanson, F., Allen, K., Cross, A., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: XIV European Meeting on Glial Cells in Health and Disease, Porto, Portugal

    Hanson, F., Allen, K., Cross, A., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: XIV European Meeting on Glial Cells in Health and Disease, Porto, Portugal

    Hodgson, R., Allen, K., & Campbell, S. (2019). The impact of eIF2B mutations and ISR-modifying drugs on eIF2B localisation. Presented at: XIV European Meeting on Glial Cells in Health and Disease, Porto, Portugal

    Hodgson, R., Allen, K., & Campbell, S. (2019). The impact of eIF2B mutations and ISR-modifying drugs on eIF2B localisation. Presented at: XIV European Meeting on Glial Cells in Health and Disease, Porto, Portugal

    Hanson, F., Cross, A., Allen, K., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: Translation UK, University of Glasgow

    Hanson, F., Cross, A., Allen, K., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: Translation UK, University of Glasgow

    Hodgson, R., Allen, K., Cross, A., & Campbell, S. (2019). The impact of eIF2B mutations and ISR-modifying drugs on eIF2B localisation. Presented at: Translation UK, University of Glasgow

    Hodgson, R., Allen, K., Cross, A., & Campbell, S. (2019). The impact of eIF2B mutations and ISR-modifying drugs on eIF2B localisation. Presented at: Translation UK, University of Glasgow

    Campbell, S., Norris, K., Abell, B., & Ashe, M. (2018). Investigating the impact of eIF2Bα on eIF2B body localisation. Presented at: Translational Control, Cold Spring Harbor Laboratories, New York, USA

    Campbell, S., Norris, K., Abell, B., & Ashe, M. (2018). Investigating the impact of eIF2Bα on eIF2B body localisation. Presented at: Translational Control, Cold Spring Harbor Laboratories, New York, USA

    Campbell, S., Norris, K., Abell, B., & Ashe, M. (2018). Investigating the impact of eIF2Bα on eIF2B body localisation. Presented at: Translational Control, Cold Spring Harbor Laboratories, New York, USA

    Hodgson, R., Allen, K., & Campbell, S. (2018). eIF2B subunits localise to distinct populations of eIF2B bodies that allow for differential regulation by the ISR in cells linked to VWM. Presented at: Translational Control, Cold Spring Harbor Laboratories

    Hodgson, R., Allen, K., & Campbell, S. (2018). eIF2B subunits localise to distinct populations of eIF2B bodies that allow for differential regulation by the ISR in cells linked to VWM. Presented at: Translational Control, Cold Spring Harbor Laboratories

    Hodgson, R., Allen, K., & Campbell, S. (2017). eIF2B subcomplexes display differential control of translation initiation in cells directly affected by VWM. Presented at: Translation UK, University of Nottingham

    Hodgson, R., Allen, K., & Campbell, S. (2017). eIF2B subcomplexes display differential control of translation initiation in cells directly affected by VWM. Presented at: Translation UK, University of Nottingham

    Norris, K., Abell, B., Ashe, M., & Campbell, S. (2017). The Role of Gcn3 in the formation of eIF2B Bodies. Presented at: Translation UK, The University of Nottingham

    Norris, K., Abell, B., Ashe, M., & Campbell, S. (2017). The Role of Gcn3 in the formation of eIF2B Bodies. Presented at: Translation UK, The University of Nottingham

    Campbell, S., Hodgson, R., Allen, K., & Abreu Varanda, B. (2016). eIF2B SUB COMPLEXES EXIST IN CELLS LINKED TO VWM. Presented at: Translational Control, Cold Spring Harbor Laboratories, Long Island, USA

    Norris, K., Abell, B., Ashe, M., & Campbell, S. (2016). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: Translational Control, Cold Spring Harbor Laboratories

    Norris, K., Abell, B., Ashe, M., & Campbell, S. (2016). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: Translational Control, Cold Spring Harbor Laboratories

    Hodgson, R., Allen, K., & Campbell, S. (2016). Characterisation of the Functional Significance of eIF2B Bodies in Leukoencephalopathy with Vanishing White Matter. Presented at: Translation UK, University of Surrey

    Hodgson, R., Allen, K., & Campbell, S. (2016). Characterisation of the Functional Significance of eIF2B Bodies in Leukoencephalopathy with Vanishing White Matter. Presented at: Translation UK, University of Surrey

    Norris, K., Abell, B., Ashe, M., & Campbell, S. (2016). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: Translation UK, University of Surrey

    Norris, K., Abell, B., Ashe, M., & Campbell, S. (2016). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: Translation UK, University of Surrey

    Norris, K., Abell, B., Ashe, M., & Campbell, S. (2015). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: Translation UK, University of Aberdeen

    Norris, K., Abell, B., Ashe, M., & Campbell, S. (2015). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: Translation UK, University of Aberdeen

    Norris, K., Abell, B., Ashe, M., & Campbell, S. (2015). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: British Yeast Group Meeting, The University of Manchester

    Norris, K., Abell, B., Ashe, M., & Campbell, S. (2015). The Role of Membrane Associated eIF2B Bodies in Translational Regulation. Presented at: British Yeast Group Meeting, The University of Manchester

    Campbell, S., & Ashe, M. (2014). eIF2Bα, a key factor in the integrity of eIF2B bodies. Presented at: Translational Control, Cold Spring Harbor Laboratories

    Campbell, S., Martins, I., Jacquemet, G., & Ashe, M. (2014). eIF2Ba A KEY FACTOR IN THE INTEGRITY OF eIF2B BODIES. Presented at: British Yeast Group Meeting, The University of Exeter

    Campbell, S. (2009). Gcn3 is involved in the formation of eIF2B bodies. Presented at: Translation UK, University of Warick

    Campbell, S., Taylor, E., Reid, P., & Ashe, M. (2009). eIF2BA KEY FACTOR IN THE INTEGRITY OF eIF2B BODIES. Presented at: Translation UK, University of Warick

    Campbell, S., Hoyle, N., Griffiths, C., & Ashe, M. (2008). Discrete cytoplasmic foci represent sites of eIF2 and eIF2B localisation in the yeast Saccharoymces cerevisiae. Presented at: Translational Control, Cold Spring Harbor Laboratories

    Campbell, S., Reid, P., & Ashe, M. (2008). eIF2/eIF2B bodies and their control in translation initiation and cell physiology. Presented at: Translation UK, University of Manchester

    Campbell, S., Hoyle, N., Grifffiths, C., & Ashe, M. (2007). Characterisation of eIF2/eIF2B bodies in the yeast Saccharomyces cerevisiae. Presented at: Translation UK, University of Nottingham

    Campbell, S. (2006). eIF2B bodies and their control in translation. Presented at: Translation UK, University of Newcastle

    Ashe, M., & Campbell, S. (2006). Characterisation of eIF2/eIF2B bodies in the yeast Saccharomyces cerevisiae. Presented at: British Yeast Group Meeting

    Campbell, S., & Ashe, M. (2004). Discrete cytoplasmic foci respresent sites of eIF2 and eIF2B localisation in the yeast Saccharomyces cerevisiae. Presented at: Translational Control, Cold Spring Harbor Laboratories

  • Postgraduate supervision

    Previous supervision: 

    Karl Norris - The role of membrane associated elF2B complexes in translational regulation

    Rachel Hodgson - Characterisation of eIF2B bodies in vanishing white matter disease

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