Summary
Following completion of a BSc in Biomedical Sciences at Glasgow University and an MSc in Pathological Sciences at Sheffield Hallam University, I started working at Sheffield University as a research technician. I went on to complete a PhD investigating the catalytic activity of bacterial oxygenases, followed by a number of postdoctoral positions developing antibiotic eluting medical devices and antimicrobial coatings.
I was appointed as a lecturer in biological sciences here at Sheffield Hallam University in 2016. I am also an active researcher in antimicrobial coatings, bacterial biofilms, bacterial oxygenases and biocatalysis.
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About
Following completion of a BSc in Biomedical Sciences at Glasgow University and an MSc in Pathological Sciences at Sheffield Hallam University, I started working at Sheffield University as a research technician. I went on to complete a PhD investigating the catalytic activity of bacterial oxygenases, followed by a number of postdoc positions developing antibiotic eluting medical devices and antimicrobial coatings.
I was appointed as a lecturer in biological sciences here at Sheffield Hallam University in 2016. I am also an active researcher in antimicrobial coatings, bacterial biofilms, bacterial oxygenases and biocatalysis.
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Teaching
I teach microbiology and infection control to bioscience, chemistry and nursing students. I also deliver on the Professional and Scientific Practice modules.
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Research
Antimicrobial coatings
Antibiotic drug delivery systems Bacterial oxygenases
Biocatalysis -
Publications
Journal articles
Pakiet, M., Kowalczyk, I., Leiva Garcia, R., Moorcroft, R., Nichol, T., Smith, T., ... Brycki, B. (2019). Gemini surfactant as multifunctional corrosion and biocorrosion inhibitors for mild steel. Bioelectrochemistry, 128, 252-262. http://doi.org/10.1016/j.bioelechem.2019.04.005
Lock, M., Nichol, T., Murrell, J.C., & Smith, T. (2017). Mutagenesis and expression of methane monooxygenase to alter regioselectivity with aromatic substrates. FEMS microbiology letters, 364 (13), fnx137. http://doi.org/10.1093/femsle/fnx137
Frew, N.M., Cannon, T., Nichol, T., Smith, T., & Stockley, I. (2017). Comparison of the elution properties of commercially available gentamicin and bone cement containing vancomycin with 'home-made' preparations. The bone & joint journal, 98-B (1), 73-77. http://doi.org/10.1302/0301-620X.99B1.BJJ-2016-0566.R1
Nichol, T., Smith, T., Townsend, R., Stockley, I., & Akid, R. (2016). Analysis of linezolid and tigecycline as candidates for local prophylaxis via antibiotic-loaded bone cement. The Journal of antimicrobial chemotherapy, 72 (2), 410-416. http://doi.org/10.1093/jac/dkw410
Salih, S., Paskins, A., Nichol, T., Smith, T., & Hamer, A. (2015). The cement spacer with multiple indentations : increasing antibiotic elution using a cement spacer 'teabag'. The Bone & Joint Journal, 97-B (11), 1519-1524. http://doi.org/10.1302/0301-620X.97B11.35618
Nichol, T., Murrell, J.C., & Smith, T.J. (2015). Controlling the activities of the Diiron Centre in bacterial monooxygenases: lessons from mutagenesis and biodiversity. European Journal of Inorganic Chemistry, 2015 (21), 3419-3431. http://doi.org/10.1002/ejic.201500043
Barker, S., Nichol, T., Harrison, P.L., Stockley, I., Townsend, R., & Smith, T.J. (2015). Temocillin: a new candidate antibiotic for local antimicrobial delivery in orthopaedic surgery? The Journal of antimicrobial chemotherapy, 70 (3), 780-783. http://doi.org/10.1093/jac/dku425
Dodds, S., Smith, T.S., Akid, R., Stephenson, J., Nichol, T., Banerjee, R.D., ... Townsend, R. (2011). Contrasting effects of physical wear on elution of two antibiotics from orthopaedic cement. Antimicrobial Agents and Chemotherapy, 56 (3), 1471-1475. http://doi.org/10.1128/AAC.01588-10
Borodina, E., Nichol, T., Dumont, M.G., Smith, T.J., & Murrell, J.C. (2007). Mutagenesis of the "Leucine Gate" to explore the basis of catalytic versatility in soluble methane monooxygenase. Applied and environmental microbiology, 73 (20), 6460-6467. http://doi.org/10.1128/AEM.00823-07
Book chapters
Smith, T.J., & Nichol, T. (2018). Engineering soluble methane monooxygenase for biocatalysis. In Kalyuzhnaya, M.G., & Xin-Hui, X. (Eds.) Methane biocatalysis: Paving the way to sustainability. (pp. 153-168). Springer International Publishing: http://doi.org/10.1007/978-3-319-74866-5_10