Vikki was appointed as a lecturer in analytical science at Sheffield Hallam University in 1995, after completing a BSc (Hons) degree in Chemistry (with Analytical Chemistry) followed by a PhD at the University of Manchester Institute of Science and Technology (UMIST).
She teaches analytical science, including separation science and surface analysis, to both undergraduate and postgraduate students. As Undergraduate Academic Delivery Lead, Vikki oversees the Bioscience and Chemistry Undergraduate programme of courses. Her research interests are in the application of separation science, surface analysis and mass spectrometric techniques to real-world problems.
Vikki studied Chemistry with Analytical Chemistry at UMIST (now part of University of Manchester) and followed the BSc with a PhD in Chemistry (surface analysis) also at UMIST. After completing postdoctoral research at the Universities of Nottingham and Bradford, applying analytical science to problems in pharmaceutical science and archaeology, she joined Sheffield Hallam in 1995 as a lecturer in analytical science. She has taught chemistry to non-chemists, introductory analytical science, separation science and surface analysis to both undergraduate and postgraduate students.
Vikki is also the Undergraduate Academic Delivery Lead for the Department of Biosciences and Chemistry, overseeing the programme of courses and working with course leaders to ensure an excellent student experience. Previous roles have included academic placement tutor for the department as well as course leader of various Chemistry courses. Development of employability skills is vital to success as a graduate and Vikki is heavily involved in motivating and enabling students to improve and evidence their employability.
Research interests remain in the application of analytical techniques to real-life problems, for example collaborating with scientists at the HSL in the development of methodologies to monitor occupational exposure to arsenic, chromium, silicon and their species.
She has been a committee member for the Royal Society of Chemistry Sheffield and District local section since 1997. This involves the organisation of local RSC events and activities to promote chemistry to the wider community, allowing networking of professionals in the chemical sciences community.
Specialist areas of interest
Vikki teaches analytical science, with a particular interest in separation science and surface analysis. She is keen to promote the real-world application of analytical techniques to students and includes examples from many aspects of science, including her own research, illustrating to students the capabilities of these techniques. These topics are taught at both undergraduate and postgraduate level.
As well as analytical science, Vikki leads a final year undergraduate module which helps students develop and evidence their communication and employability skills. Careers and employability advisors, as well as information specialists, contribute to the module to ensure students have the necessary knowledge and skills to make productive choices about their future careers as science graduates.
Biosciences and Chemistry undergraduate programme
MSc Analytical Chemistry
Vikki's current research is in the development and application of chromatographic and mass spectrometric techniques. She is part of the Bioanalytical Science group within the Biomolecular Sciences Research centre, collborating with Prof Malcolm Clench and Dr Philip Gardiner. She has worked closely with scientists at the Health & Safety Laboratory developing methods based on LC-ICP-MS to monitor occupational exposure to arsenic, chromium, silica and their species. This has also involved the development of novel sampling methodologies.
Dr Jackie Morton, Health and Safety Laboratory
LEESE, Elizabeth, STAFF, James F., CAROLAN, Vikki and MORTON, Jackie (2017). Exhaled breath condensate: a novel matrix for biological monitoring to assess occupational exposure to respirable crystalline silica. Annals of work exposures and health, 61 (7), 902-906.
DJIDJA, Marie-Claude, CLAUDE, Emmanuelle, SCRIVEN, Peter, ALLEN, David, CAROLAN, Vikki and CLENCH, Malcolm (2017). Antigen retrieval prior to on-tissue digestion of formalin-fixed paraffin-embedded tumour tissue sections yields oxidation of proline residues. Biochimica et biophysica acta, 1865 (7), 901-906.
LEESE, Elizabeth, CLENCH, Malcolm, MORTON, Jackie, GARDINER, Philip and CAROLAN, Vikki (2017). The investigation of unexpected arsenic compounds observed in routine biological monitoring urinary speciation analysis. Toxics, 5 (2), p. 12.
LEESE, Elizabeth, MORTON, Jackie, GARDINER, Philip and CAROLAN, Vikki (2016). The simultaneous detection of trivalent & hexavalent chromium in exhaled breath condensate: A feasibility study comparing workers and controls. International Journal of Hygiene and Environmental Health. (In Press)
LEESE, Elizabeth, MORTON, Jackie, GARDINER, Philip and CAROLAN, Vikki (2016). Development of a method for the simultaneous detection of Cr(iii) and Cr(vi) in exhaled breath condensate samples using μLC-ICP-MS. Journal of analytical atomic spectrometry, 31 (4), 924-933.
LEESE, Elizabeth, MORTON, Jackie, TAN, Emma, GARDINER, Philip H.E. and CAROLAN, Vikki A. (2014). µLC-ICP-MS determinations of unexposed UK urinary arsenic speciation reference values. Journal of Analytical Toxicology, 38 (1), 24-30.
COLE, Laura, BLUFF, Joanne E., CAROLAN, Vikki, PALEY, Martyn N., TOZER, Gillian M. and CLENCH, Malcolm (2014). MALDI-MSI and label-free LC-ESI-MS/MS shotgun proteomics to investigate protein induction in a murine fibrosarcoma model following treatment with a vascular disrupting agent. Proteomics, 14 (7-8), 890-903.
DJIDJA, Marie-Claude, FRANCESE, Simona, CLAUDE, Emmanuelle, LOADMAN, Paul, SUTTON, Chris, SHYNDER, Steve, COOPER, Patricia, PATTERSON, Laurence H, CAROLAN, Vikki and CLENCH, Malcolm (2013). Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging. Current Analytical Chemistry, 9 (2), 212-225.
TRIM, Paul J, DJIDJA, Marie-Claude, MUHARIB, Tasneem, COLE, Laura M, FLINDERS, Bryn, CAROLAN, Vikki, FRANCESE, Simona and CLENCH, Malcolm (2012). Instrumentation and software for mass spectrometry imaging -making the most of what you've got. Journal of Proteomics, 75 (16), 4931-4940.
COLE, Laura, DJIDJA, M-C, BLUFF, J., CLAUDE, E, CAROLAN, Vikki, PALEY, M, TOZER, G M and CLENCH, Malcolm (2011). Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI. Methods, 54 (4), 442-453.
EARNSHAW, C. J., CAROLAN, V. A., RICHARDS, D. S. and CLENCH, M. R. (2010). Direct analysis of pharmaceutical tablet formulations using matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid Communications in Mass Spectrometry, 24 (11), 1665-1672.
ANDERSON, D. M. G., CAROLAN, V. A., CROSLAND, S., SHARPLES, K. R. and CLENCH, M. R. (2010). Examination of the translocation of sulfonylurea herbicides in sunflower plants by matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid Communications in Mass Spectrometry, 24 (22), 3309-3319.
DJIDJA, M. C., CLAUDE, E., SNEL, M. F., FRANCESE, S., SCRIVEN, P., CAROLAN, V. and CLENCH, M. R. (2010). Novel molecular tumour classification using MALDI-mass spectrometry imaging of tissue micro-array. Analytical and Bioanalytical Chemistry, 397 (2), 587-601.
ANDERSON, D. M. G., CAROLAN, V. A., CROSLAND, S., SHARPLES, K. R. and CLENCH, M. R. (2009). Examination of the distribution of nicosulfuron in sunflower plants by matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid communications in mass spectrometry, 23 (9), 1321-1327.
DJIDJA, M.-C., CLAUDE, E., SNEL, M. F., SCRIVEN, P., FRANCESE, S., CAROLAN, V. and CLENCH, M. R. (2009). MALDI-Ion Mobility Separation-Mass Spectrometry Imaging of Glucose-Regulated Protein 78 kDa (Grp78) in Human Formalin-Fixed, Paraffin-Embedded Pancreatic Adenocarcinoma Tissue Sections. Journal of Proteome Research, 8 (10), 4876-4884.
DJIDJA, M. C., CLAUDE, E., SNEL, M. F., SCRIVEN, P., FRANCESE, S., CAROLAN, V. and CLENCH, M. R. (2009). MALDI-ion mobility separation-mass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffin-embedded pancreatic adenocarcinoma tissue Sections. Journal of proteome research, 8 (10), 4876-4884.
DJIDJA, M. C., CAROLAN, V., LOADMAN, P. M. and CLENCH, M. R. (2008). Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid communications in mass spectrometry, 22 (10), 1615-1618.
DELOGNE, C., LAWFORD, P. V., HABESCH, S. M. and CAROLAN, V. A. (2007). Characterization of the calcification of cardiac valve bioprostheses by environmental scanning electron microscopy and vibrational spectroscopy. Journal of microscopy, 228 (1), 62-77.
PRIDEAUX, B., ATKINSON, S. J., CAROLAN, V. A., MORTON, J. and CLENCH, M. R. (2006). Sample preparation and data interpretation procedures for the examination of xenobiotic compounds in skin by indirect imaging MALDI-MS. International journal of mass spectrometry, 260 (2-3), 243-251.
MORTON, J., CAROLAN, V. A. and GARDINER, P. H. E. (2002). The speciation of inorganic and methylmercury in human hair by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry. Journal of analytical atomic spectrometry, 17 (4), p. 377.
MORTON, J., CAROLAN, V. A. and GARDINER, P. H. E. (2001). Removal of exogenously bound elements from human hair by various washing procedures and determination by inductively coupled plasma mass spectrometry. Analytica chimica acta, 455 (1), 23-34.
BARRETT, D. A., BROWN, V. A., WATSON, R. C., DAVIES, M. C., SHAW, P. N., RITCHIE, H. J. and ROSS, P. (2000). Effects of acid treatment on the trace metal content of chromatographic silica: bulk analysis, surface analysis and chromatographic performance of bonded phases. Journal of chromatography A, 905 (1-2), 69-83.
Vikki is a Fellow of both the Higher Education Academy and the Royal Society of Chemistry. She is also a committee member for the Royal Society of Chemistry Sheffield and District local section.
PT PhD 2010-2017
Analytical Methods To Investigate Occupational Exposure To Toxic Metals And Their Species
1997-2001 Development and Application of Capillary Electrochromatography using Modular Instrumentation.
1998-2002 Characterisation of the Cross-linking and Calcification Associated with Glutaraldehyde-Treated Cardiac Bioprostheses.
Also second supervisor to 12 successful PhD students 1997-2015.
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