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Centre for Mass Spectrometry Imaging (CMSI)

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Centre for Mass Spectrometry Imaging (CMSI)

Mass Spectrometry Imaging (MSI) describes a group of label-free imaging techniques that can be used to study the distribution of a range of compounds in biological tissues and other sample types.

The Centre for Mass Spectrometry Imaging (CMSI) is dedicated to the advancement of these techniques and their application to problems in biological, pharmaceutical and environmental analysis.

Currently the Centre is equipped for matrix-assisted laser desorption ionisation mass spectrometry imaging (MALDI-MSI), liquid extraction surface analysis mass spectrometry imaging (LESA-MSI), desorption electrospray ionisation mass spectrometry imaging instrumentation (DESI-MSI) and laser ablation inductively couple plasma mass spectrometry imaging (LA-ICP-MS).

The Director of the Centre is Professor Malcolm Clench working with Prof Simona Francese, Dr Tom Bassindale, Professor Neil BricklebankDr Catherine Duckett, Dr David SmithDr Neil Cross, Dr Rob Bradshaw and Dr Laura Cole.

We have expertise in the study of a wide range of molecules using MSI including

  • cellular metabolites
  • lipids
  • pharmaceutical compounds
  • drugs of abuse
  • peptides and proteins
  • agrochemicals in food crops

We have used this technique successfully in a number of projects including

  • forensic analysis of fingermarks and suspect identification
  • biomarker discovery of tumorigenesis
  • biological response to honeybee venom
  • xenobiotics skin absorption and drug mapping
  • distribution of anti-cancer drugs in tumours
  • changes in protein and lipid expression when skin is exposed to sensitising chemicals

Related staff

Malcolm Clench

Prof. Malcolm Clench

Professor of Mass Spectrometry, Head of the Biomolecular Sciences Research Centre

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Simona Francese

Professor Simona Francese

Professor of Forensic and Bioanalytical Mass Spectrometry

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Catherine Duckett stood posing for a photo

Dr Catherine Duckett

Senior Lecturer in Analytical Science

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David Smith

Dr David Smith

Reader in Biochemistry / Course Leader MSc Molecular and Cellular Biology and National Teaching Fellow

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Neil Bricklebank 113641

Professor Neil Bricklebank

Professor of Chemistry

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Tom Bassindale

Dr Thomas Bassindale

Principal Lecturer in Forensic and Analytical Science. Professional Lead, Chemistry and Forensic Science

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Neil Cross

Dr Neil Cross

Reader in Cancer Biology

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Robert Bradshaw 211016

Dr Rob Bradshaw

Lecturer in Analytical Science

Robert Bradshaw
Laura Cole 207831

Dr Laura Cole

Lecturer in Biomedical Science

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Get in touch

Contact the BMRC to discuss facilities, partnerships, doctoral research and more

Email BMRC